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Items: 1 to 20 of 79

1.

Presenilin-2 modulation of ER-mitochondria interactions: FAD mutations, mechanisms and pathological consequences.

Zampese E, Fasolato C, Pozzan T, Pizzo P.

Commun Integr Biol. 2011 May;4(3):357-60. doi: 10.4161/cib.4.3.15160.

2.

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.

Zampese E, Fasolato C, Kipanyula MJ, Bortolozzi M, Pozzan T, Pizzo P.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2777-82. doi: 10.1073/pnas.1100735108.

3.

Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.

Zatti G, Burgo A, Giacomello M, Barbiero L, Ghidoni R, Sinigaglia G, Florean C, Bagnoli S, Binetti G, Sorbi S, Pizzo P, Fasolato C.

Cell Calcium. 2006 Jun;39(6):539-50.

PMID:
16620965
4.

Thapsigargin affects presenilin-2 but not presenilin-1 regulation in SK-N-BE cells.

Rivabene R, Visentin S, Piscopo P, De Nuccio C, Crestini A, Svetoni F, Rosa P, Confaloni A.

Exp Biol Med (Maywood). 2014 Feb;239(2):213-24. doi: 10.1177/1535370213514317.

PMID:
24363250
5.

Ca2+ dysregulation in neurons from transgenic mice expressing mutant presenilin 2.

Kipanyula MJ, Contreras L, Zampese E, Lazzari C, Wong AK, Pizzo P, Fasolato C, Pozzan T.

Aging Cell. 2012 Oct;11(5):885-93. doi: 10.1111/j.1474-9726.2012.00858.x.

6.

Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2.

Filadi R, Greotti E, Turacchio G, Luini A, Pozzan T, Pizzo P.

Cell Rep. 2016 Jun 7;15(10):2226-38. doi: 10.1016/j.celrep.2016.05.013.

7.

Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1.

Nelson O, Tu H, Lei T, Bentahir M, de Strooper B, Bezprozvanny I.

J Clin Invest. 2007 May;117(5):1230-9.

8.

Presenilins and Alzheimer's disease: biological functions and pathogenic mechanisms.

Czech C, Tremp G, Pradier L.

Prog Neurobiol. 2000 Mar;60(4):363-84. Review.

PMID:
10670705
9.

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations.

Tu H, Nelson O, Bezprozvanny A, Wang Z, Lee SF, Hao YH, Serneels L, De Strooper B, Yu G, Bezprozvanny I.

Cell. 2006 Sep 8;126(5):981-93.

10.

Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations.

Katayama T, Imaizumi K, Honda A, Yoneda T, Kudo T, Takeda M, Mori K, Rozmahel R, Fraser P, George-Hyslop PS, Tohyama M.

J Biol Chem. 2001 Nov 16;276(46):43446-54.

11.

FAD-linked Presenilin-1 V97L mutation impede tranport regulation and intracellular Ca(2+) homeostasis under ER stress.

Shao Y, Li M, Wu M, Shi K, Fang B, Wang J.

Int J Clin Exp Med. 2015 Nov 15;8(11):20742-50.

12.

Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake.

Brunello L, Zampese E, Florean C, Pozzan T, Pizzo P, Fasolato C.

J Cell Mol Med. 2009 Sep;13(9B):3358-69. doi: 10.1111/j.1582-4934.2009.00755.x.

13.
15.

Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease.

Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Lippa CF, Bird TD, Nochlin D, Walter J, Haass C, Lévesque L, Fraser PE, Andreadis A, Nixon RA.

Mol Med. 2000 Oct;6(10):878-91.

17.

Using a genetically targeted sensor to investigate the role of presenilin-1 in ER Ca2+ levels and dynamics.

McCombs JE, Gibson EA, Palmer AE.

Mol Biosyst. 2010 Sep;6(9):1640-9. doi: 10.1039/c001975e.

18.

Impaired mitochondrial function due to familial Alzheimer's disease-causing presenilins mutants via Ca(2+) disruptions.

Toglia P, Cheung KH, Mak DO, Ullah G.

Cell Calcium. 2016 May;59(5):240-50. doi: 10.1016/j.ceca.2016.02.013.

19.

Amino- and carboxyl-terminal mutants of presenilin 1 cause neuronal cell death through distinct toxic mechanisms: Study of 27 different presenilin 1 mutants.

Hashimoto Y, Tsukamoto E, Niikura T, Yamagishi Y, Ishizaka M, Aiso S, Takashima A, Nishimoto I.

J Neurosci Res. 2004 Feb 1;75(3):417-28.

PMID:
14743455
20.

Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.

Terro F, Czech C, Esclaire F, Elyaman W, Yardin C, Baclet MC, Touchet N, Tremp G, Pradier L, Hugon J.

J Neurosci Res. 2002 Aug 15;69(4):530-9.

PMID:
12210846
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