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Items: 1 to 20 of 90

1.

Debrisoquine metabolism and CYP2D expression in marmoset liver microsomes.

Cooke BR, Bligh SW, Cybulski ZR, Ioannides C, Hall M.

Drug Metab Dispos. 2012 Jan;40(1):70-5. doi: 10.1124/dmd.111.041566.

3.

Catalytic specificity of CYP2D isoforms in rat and human.

Hiroi T, Chow T, Imaoka S, Funae Y.

Drug Metab Dispos. 2002 Sep;30(9):970-6.

4.

Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling.

Lightfoot T, Ellis SW, Mahling J, Ackland MJ, Blaney FE, Bijloo GJ, De Groot MJ, Vermeulen NP, Blackburn GM, Lennard MS, Tucker GT.

Xenobiotica. 2000 Mar;30(3):219-33.

PMID:
10752638
5.

3,4-Dehydrodebrisoquine, a novel debrisoquine metabolite formed from 4-hydroxydebrisoquine that affects the CYP2D6 metabolic ratio.

Zhen Y, Slanar O, Krausz KW, Chen C, Slavík J, McPhail KL, Zabriskie TM, Perlík F, Gonzalez FJ, Idle JR.

Drug Metab Dispos. 2006 Sep;34(9):1563-74.

7.

Assay and characterisation of debrisoquine 4-hydroxylase activity of microsomal fractions of human liver.

Kahn GC, Boobis AR, Murray S, Brodie MJ, Davies DS.

Br J Clin Pharmacol. 1982 May;13(5):637-45.

8.

Relationship between oxidative metabolism of 2-acetylaminofluorene, debrisoquine, bufuralol, and aldrin in human liver microsomes.

McManus ME, Boobis AR, Minchin RF, Schwartz DM, Murray S, Davies DS, Thorgeirsson SS.

Cancer Res. 1984 Dec;44(12 Pt 1):5692-7.

9.

Is cytochrome P450 CYP2D activity present in pig liver?

Skaanild MT, Friis C.

Pharmacol Toxicol. 2002 Oct;91(4):198-203.

PMID:
12530471
10.

Substrate specificity of human liver cytochrome P-450 debrisoquine 4-hydroxylase probed using immunochemical inhibition and chemical modeling.

Wolff T, Distlerath LM, Worthington MT, Groopman JD, Hammons GJ, Kadlubar FF, Prough RA, Martin MV, Guengerich FP.

Cancer Res. 1985 May;45(5):2116-22.

12.

Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A.

Niwa T, Shiraga T, Mitani Y, Terakawa M, Tokuma Y, Kagayama A.

Drug Metab Dispos. 2000 Sep;28(9):1128-34.

14.

Characterization of the oxidation reactions catalyzed by CYP2D enzyme in rat renal microsomes.

Masubuchi Y, Yamamoto K, Suzuki T, Horie T, Narimatsu S.

Life Sci. 1996 May 24;58(26):2431-7.

PMID:
8691988
15.

A study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and of testosterone metabolism in bovine liver.

Sivapathasundaram S, Magnisali P, Coldham NG, Howells LC, Sauer MJ, Ioannides C.

Biochem Pharmacol. 2001 Sep 1;62(5):635-45.

PMID:
11585060
16.

Coordinated intrahepatic and extrahepatic regulation of cytochrome p4502D6 in healthy subjects and in patients after liver transplantation.

Carcillo JA, Adedoyin A, Burckart GJ, Frye RF, Venkataramanan R, Knoll C, Thummel K, Roskos L, Wilson JW, Sereika S, Romkes M, Bebia Z, Branch RA.

Clin Pharmacol Ther. 2003 May;73(5):456-67.

PMID:
12732845
17.

In vitro evidence against the oxidation of quinidine by the sparteine/debrisoquine monooxygenase of human liver.

Otton SV, Brinn RU, Gram LF.

Drug Metab Dispos. 1988 Jan-Feb;16(1):15-7.

PMID:
2894945
18.

Cloning and functional expression of a novel marmoset cytochrome P450 2D enzyme, CYP2D30: comparison with the known marmoset CYP2D19.

Hichiya H, Kuramoto S, Yamamoto S, Shinoda S, Hanioka N, Narimatsu S, Asaoka K, Miyata A, Iwata S, Nomoto M, Satoh T, Kiryu K, Ueda N, Naito S, Tucker GT, Ellis SW.

Biochem Pharmacol. 2004 Jul 1;68(1):165-75.

PMID:
15183128
19.

Comparative metabolism of debrisoquine, 7-ethoxyresorufin and benzo(a)pyrene in liver microsomes from humans, and from rats treated with cytochrome P-450 inducers.

Birgersson C, Blanck A, Woodhouse K, Mellström B, von Bahr C.

Acta Pharmacol Toxicol (Copenh). 1985 Aug;57(2):117-20.

PMID:
4061088
20.

1- and 3-hydroxylations, in addition to 4-hydroxylation, of debrisoquine are catalyzed by cytochrome P450 2D6 in humans.

Eiermann B, Edlund PO, Tjernberg A, Dalén P, Dahl ML, Bertilsson L.

Drug Metab Dispos. 1998 Nov;26(11):1096-101.

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