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Protein kinase D3 is a pivotal activator of pathological cardiac hypertrophy by selectively increasing the expression of hypertrophic transcription factors.

Li C, Li J, Cai X, Sun H, Jiao J, Bai T, Zhou XW, Chen X, Gill DL, Tang XD.

J Biol Chem. 2011 Nov 25;286(47):40782-91. doi: 10.1074/jbc.M111.263046. Epub 2011 Oct 4.


Peroxisome proliferator-activated receptor gamma coactivator 1 alpha protects cardiomyocytes from hypertrophy by suppressing calcineurin-nuclear factor of activated T cells c4 signaling pathway.

Liu XP, Gao H, Huang XY, Chen YF, Feng XJ, He YH, Li ZM, Liu PQ.

Transl Res. 2015 Nov;166(5):459-473.e3. doi: 10.1016/j.trsl.2015.06.003. Epub 2015 Jun 9.


TGF-beta1 induces cardiac hypertrophic responses via PKC-dependent ATF-2 activation.

Lim JY, Park SJ, Hwang HY, Park EJ, Nam JH, Kim J, Park SI.

J Mol Cell Cardiol. 2005 Oct;39(4):627-36.


COX-2 is involved in ET-1-induced hypertrophy of neonatal rat cardiomyocytes: role of NFATc3.

Li H, Gao S, Ye J, Feng X, Cai Y, Liu Z, Lu J, Li Q, Huang X, Chen S, Liu P.

Mol Cell Endocrinol. 2014 Feb 15;382(2):998-1006. doi: 10.1016/j.mce.2013.11.012. Epub 2013 Nov 26.


CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo.

Passier R, Zeng H, Frey N, Naya FJ, Nicol RL, McKinsey TA, Overbeek P, Richardson JA, Grant SR, Olson EN.

J Clin Invest. 2000 May;105(10):1395-406.


NFATc4 is negatively regulated in miR-133a-mediated cardiomyocyte hypertrophic repression.

Li Q, Lin X, Yang X, Chang J.

Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1340-7. doi: 10.1152/ajpheart.00592.2009. Epub 2010 Feb 19.


Genome-Wide Gene Expression Analysis Shows AKAP13-Mediated PKD1 Signaling Regulates the Transcriptional Response to Cardiac Hypertrophy.

Johnson KR, Nicodemus-Johnson J, Spindler MJ, Carnegie GK.

PLoS One. 2015 Jul 20;10(7):e0132474. doi: 10.1371/journal.pone.0132474. eCollection 2015.


Transcriptional upregulation of calcineurin Abeta by endothelin-1 is partially mediated by calcium/calmodulin-dependent protein kinase IIdelta3 in rat cardiomyocytes.

Lu YM, Shioda N, Yamamoto Y, Han F, Fukunaga K.

Biochim Biophys Acta. 2010 May-Jun;1799(5-6):429-41. doi: 10.1016/j.bbagrm.2010.02.004. Epub 2010 Mar 6.


The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases.

Song K, Backs J, McAnally J, Qi X, Gerard RD, Richardson JA, Hill JA, Bassel-Duby R, Olson EN.

Cell. 2006 May 5;125(3):453-66.


Astragalus polysaccharide inhibits isoprenaline-induced cardiac hypertrophy via suppressing Ca²⁺-mediated calcineurin/NFATc3 and CaMKII signaling cascades.

Dai H, Jia G, Liu X, Liu Z, Wang H.

Environ Toxicol Pharmacol. 2014 Jul;38(1):263-71. doi: 10.1016/j.etap.2014.05.008. Epub 2014 Jun 13.


miR-9 and NFATc3 regulate myocardin in cardiac hypertrophy.

Wang K, Long B, Zhou J, Li PF.

J Biol Chem. 2010 Apr 16;285(16):11903-12. doi: 10.1074/jbc.M109.098004. Epub 2010 Feb 21.


Long-term activation of adenosine monophosphate-activated protein kinase attenuates pressure-overload-induced cardiac hypertrophy.

Li HL, Yin R, Chen D, Liu D, Wang D, Yang Q, Dong YG.

J Cell Biochem. 2007 Apr 1;100(5):1086-99.


Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling.

Ni YG, Berenji K, Wang N, Oh M, Sachan N, Dey A, Cheng J, Lu G, Morris DJ, Castrillon DH, Gerard RD, Rothermel BA, Hill JA.

Circulation. 2006 Sep 12;114(11):1159-68. Epub 2006 Sep 4.


Cardiac Specific Overexpression of hHole Attenuates Isoproterenol-Induced Hypertrophic Remodeling through Inhibition of Extracellular Signal-Regulated Kinases (ERKs) Signalling.

Xu W, Wang Y, Zhou J, Zhu X, Zhang S, Yuan W, Liu X, Shi Y, Cao L, Zeng Q, Jiang Z, Ye X, Wan Y, Peng X, Deng Y, Chen F, Wang X, Dai G, Luo S, Fan X, Mo X, Wu X, Li Y.

Curr Mol Med. 2016;16(5):515-23.


PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling.

Yang JH, Polanowska-Grabowska RK, Smith JS, Shields CW 4th, Saucerman JJ.

J Mol Cell Cardiol. 2014 Jan;66:83-93. doi: 10.1016/j.yjmcc.2013.11.001. Epub 2013 Nov 10.


Control of Pathological Cardiac Hypertrophy by Transcriptional Corepressor IRF2BP2 (Interferon Regulatory Factor-2 Binding Protein 2).

Fang J, Li T, Zhu X, Deng KQ, Ji YX, Fang C, Zhang XJ, Guo JH, Zhang P, Li H, Wei X.

Hypertension. 2017 Sep;70(3):515-523. doi: 10.1161/HYPERTENSIONAHA.116.08728. Epub 2017 Jul 17.


Adiponectin is required for cardiac MEF2 activation during pressure overload induced hypertrophy.

Dadson K, Turdi S, Hashemi S, Zhao J, Polidovitch N, Beca S, Backx PH, McDermott JC, Sweeney G.

J Mol Cell Cardiol. 2015 Sep;86:102-9. doi: 10.1016/j.yjmcc.2015.06.020. Epub 2015 Jul 19.


Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4.

Xiang F, Sakata Y, Cui L, Youngblood JM, Nakagami H, Liao JK, Liao R, Chin MT.

Am J Physiol Heart Circ Physiol. 2006 May;290(5):H1997-2006.

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