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Itk controls the spatiotemporal organization of T cell activation.

Singleton KL, Gosh M, Dandekar RD, Au-Yeung BB, Ksionda O, Tybulewicz VL, Altman A, Fowell DJ, Wülfing C.

Sci Signal. 2011 Oct 4;4(193):ra66. doi: 10.1126/scisignal.2001821.


Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization.

Tskvitaria-Fuller I, Seth A, Mistry N, Gu H, Rosen MK, Wülfing C.

J Immunol. 2006 Aug 1;177(3):1708-20.


Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP.

Labno CM, Lewis CM, You D, Leung DW, Takesono A, Kamberos N, Seth A, Finkelstein LD, Rosen MK, Schwartzberg PL, Burkhardt JK.

Curr Biol. 2003 Sep 16;13(18):1619-24.


Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading.

Carrizosa E, Gomez TS, Labno CM, Klos Dehring DA, Liu X, Freedman BD, Billadeau DD, Burkhardt JK.

J Immunol. 2009 Dec 1;183(11):7352-61. doi: 10.4049/jimmunol.0900973. Epub 2009 Nov 16.


The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.

Granum S, Sundvold-Gjerstad V, Gopalakrishnan RP, Berge T, Koll L, Abrahamsen G, Sørlie M, Spurkland A.

Sci Signal. 2014 Dec 9;7(355):ra118. doi: 10.1126/scisignal.2005384.


Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages.

Mehta H, Glogauer M, Bécart S, Altman A, Coggeshall KM.

J Biol Chem. 2009 May 1;284(18):11882-91. doi: 10.1074/jbc.M809712200. Epub 2009 Feb 27.


TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation.

Nayar R, Enos M, Prince A, Shin H, Hemmers S, Jiang JK, Klein U, Thomas CJ, Berg LJ.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):E2794-802. doi: 10.1073/pnas.1205742109. Epub 2012 Sep 24.


SLAT regulates CD8+ T cell clonal expansion in a Cdc42- and NFAT1-dependent manner.

Feau S, Schoenberger SP, Altman A, Bécart S.

J Immunol. 2013 Jan 1;190(1):174-83. doi: 10.4049/jimmunol.1201685. Epub 2012 Nov 28.


Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis.

Guo F, Hildeman D, Tripathi P, Velu CS, Grimes HL, Zheng Y.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18505-10. doi: 10.1073/pnas.1010249107. Epub 2010 Oct 11.


DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies.

Hey F, Czyzewicz N, Jones P, Sablitzky F.

J Biol Chem. 2012 Sep 7;287(37):31073-84. doi: 10.1074/jbc.M112.346767. Epub 2012 Jul 24.


Protein transduction as a means of effective manipulation of Cdc42 activity in primary T cells.

Tskvitaria-Fuller I, Mistry N, Sun S, Wülfing C.

J Immunol Methods. 2007 Jan 30;319(1-2):64-78. Epub 2006 Dec 8.


The actin-driven spatiotemporal organization of T-cell signaling at the system scale.

Roybal KT, Sinai P, Verkade P, Murphy RF, Wülfing C.

Immunol Rev. 2013 Nov;256(1):133-47. doi: 10.1111/imr.12103. Review.


Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.

Dombroski D, Houghtling RA, Labno CM, Precht P, Takesono A, Caplen NJ, Billadeau DD, Wange RL, Burkhardt JK, Schwartzberg PL.

J Immunol. 2005 Feb 1;174(3):1385-92.


Inhibition of IL-2 inducible T-cell kinase alleviates T-cell activation and murine myocardial inflammation associated with CVB3 infection.

He F, Yao H, Xiao Z, Han J, Zou J, Liu Z.

Mol Immunol. 2014 May;59(1):30-8. doi: 10.1016/j.molimm.2013.12.004. Epub 2014 Jan 22.


Requirement for Tec kinases in chemokine-induced migration and activation of Cdc42 and Rac.

Takesono A, Horai R, Mandai M, Dombroski D, Schwartzberg PL.

Curr Biol. 2004 May 25;14(10):917-22.


Rho GTPases link cytoskeletal rearrangements and activation processes induced via the tetraspanin CD82 in T lymphocytes.

Delaguillaumie A, Lagaudrière-Gesbert C, Popoff MR, Conjeaud H.

J Cell Sci. 2002 Jan 15;115(Pt 2):433-43.

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