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Items: 1 to 20 of 143

1.

The molecular genetics of sulfonylurea receptors in the pathogenesis and treatment of insulin secretory disorders and type 2 diabetes.

Lang V, Youssef N, Light PE.

Curr Diab Rep. 2011 Dec;11(6):543-51. doi: 10.1007/s11892-011-0233-8. Review.

PMID:
21968738
2.

Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel.

Hamming KS, Soliman D, Matemisz LC, Niazi O, Lang Y, Gloyn AL, Light PE.

Diabetes. 2009 Oct;58(10):2419-24. doi: 10.2337/db09-0143. Epub 2009 Jul 8.

3.

A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults.

Tarasov AI, Nicolson TJ, Riveline JP, Taneja TK, Baldwin SA, Baldwin JM, Charpentier G, Gautier JF, Froguel P, Vaxillaire M, Rutter GA.

Diabetes. 2008 Jun;57(6):1595-604. doi: 10.2337/db07-1547. Epub 2008 Mar 17.

4.

The ATP-sensitive K(+) channel ABCC8 S1369A type 2 diabetes risk variant increases MgATPase activity.

Fatehi M, Raja M, Carter C, Soliman D, Holt A, Light PE.

Diabetes. 2012 Jan;61(1):241-9. doi: 10.2337/db11-0371.

5.

Permanent neonatal diabetes due to activating mutations in ABCC8 and KCNJ11.

Edghill EL, Flanagan SE, Ellard S.

Rev Endocr Metab Disord. 2010 Sep;11(3):193-8. doi: 10.1007/s11154-010-9149-x. Review.

PMID:
20922570
6.

Diabetes in very young children and mutations in the insulin-secreting cell potassium channel genes: therapeutic consequences.

Flechtner I, Vaxillaire M, Cavé H, Scharfmann R, Froguel P, Polak M.

Endocr Dev. 2007;12:86-98.

PMID:
17923772
7.

K(ATP) channelopathies in the pancreas.

Remedi MS, Koster JC.

Pflugers Arch. 2010 Jul;460(2):307-20. doi: 10.1007/s00424-009-0756-x. Epub 2009 Nov 18. Review.

PMID:
19921246
8.

Effects of single nucleotide polymorphisms in K(ATP) channel genes on type 2 diabetes in a Turkish population.

Gonen MS, Arikoglu H, Erkoc Kaya D, Ozdemir H, Ipekci SH, Arslan A, Kayis SA, Gogebakan B.

Arch Med Res. 2012 May;43(4):317-23. doi: 10.1016/j.arcmed.2012.06.001. Epub 2012 Jun 13.

PMID:
22704848
9.

Ontogeny of sulfonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium.

Lovasz N, Ducza E, Gaspar R, Falkay G.

Reproduction. 2011 Jul;142(1):175-81. doi: 10.1530/REP-10-0492. Epub 2011 Apr 28.

PMID:
21527399
10.

Molecular biology of K(ATP) channels and implications for health and disease.

Akrouh A, Halcomb SE, Nichols CG, Sala-Rabanal M.

IUBMB Life. 2009 Oct;61(10):971-8. doi: 10.1002/iub.246. Review.

11.

Cardiac sarcolemmal K(ATP) channels: Latest twists in a questing tale!

Zhang H, Flagg TP, Nichols CG.

J Mol Cell Cardiol. 2010 Jan;48(1):71-5. doi: 10.1016/j.yjmcc.2009.07.002. Epub 2009 Jul 14. Review.

12.

ATP-sensitive potassium channelopathies: focus on insulin secretion.

Ashcroft FM.

J Clin Invest. 2005 Aug;115(8):2047-58. Review.

13.

An abundant, truncated human sulfonylurea receptor 1 splice variant has prodiabetic properties and impairs sulfonylurea action.

Schmid D, Stolzlechner M, Sorgner A, Bentele C, Assinger A, Chiba P, Moeslinger T.

Cell Mol Life Sci. 2012 Jan;69(1):129-48. doi: 10.1007/s00018-011-0739-x. Epub 2011 Jun 14.

PMID:
21671119
14.

Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism.

Flanagan SE, Clauin S, Bellanné-Chantelot C, de Lonlay P, Harries LW, Gloyn AL, Ellard S.

Hum Mutat. 2009 Feb;30(2):170-80. doi: 10.1002/humu.20838. Review.

PMID:
18767144
15.

[Ontogeny of sulphonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium].

Lovász N, Ducza E, Gáspár R, Falkay G.

Acta Pharm Hung. 2011;81(3):101-7. Hungarian.

PMID:
22165413
16.

Compound heterozygous mutations in the SUR1 (ABCC 8) subunit of pancreatic K(ATP) channels cause neonatal diabetes by perturbing the coupling between Kir6.2 and SUR1 subunits.

Lin YW, Akrouh A, Hsu Y, Hughes N, Nichols CG, De León DD.

Channels (Austin). 2012 Mar-Apr;6(2):133-8. doi: 10.4161/chan.19980. Epub 2012 Mar 1.

18.

K(ATP) channel action in vascular tone regulation: from genetics to diseases.

Shi WW, Yang Y, Shi Y, Jiang C.

Sheng Li Xue Bao. 2012 Feb 25;64(1):1-13. Review.

19.
20.

Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes.

Männikkö R, Flanagan SE, Sim X, Segal D, Hussain K, Ellard S, Hattersley AT, Ashcroft FM.

Diabetes. 2011 Jun;60(6):1813-22. doi: 10.2337/db10-1583.

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