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Items: 1 to 20 of 76

1.

Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice.

Tian J, Huang H, Hoffman B, Liebermann DA, Ledda-Columbano GM, Columbano A, Locker J.

J Clin Invest. 2011 Nov;121(11):4491-502. doi: 10.1172/JCI38760. Epub 2011 Oct 3.

2.

Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia.

Columbano A, Ledda-Columbano GM, Pibiri M, Cossu C, Menegazzi M, Moore DD, Huang W, Tian J, Locker J.

Hepatology. 2005 Nov;42(5):1118-26.

PMID:
16231353
3.

Gadd45 in the liver: signal transduction and transcriptional mechanisms.

Tian J, Locker J.

Adv Exp Med Biol. 2013;793:69-80. doi: 10.1007/978-1-4614-8289-5_5. Review.

PMID:
24104474
4.

Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B.

Yamamoto Y, Moore R, Flavell RA, Lu B, Negishi M.

PLoS One. 2010 Apr 12;5(4):e10121. doi: 10.1371/journal.pone.0010121.

5.
6.

Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.

Shizu R, Benoki S, Numakura Y, Kodama S, Miyata M, Yamazoe Y, Yoshinari K.

PLoS One. 2013 Apr 23;8(4):e61802. doi: 10.1371/journal.pone.0061802. Print 2013.

7.

SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism.

Chen T, Chen Q, Xu Y, Zhou Q, Zhu J, Zhang H, Wu Q, Xu J, Yu C.

J Hepatol. 2012 Jan;56(1):210-7. doi: 10.1016/j.jhep.2011.07.015. Epub 2011 Aug 7.

8.
9.

Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.

Baskin-Bey ES, Huang W, Ishimura N, Isomoto H, Bronk SF, Braley K, Craig RW, Moore DD, Gores GJ.

Hepatology. 2006 Jul;44(1):252-62.

PMID:
16799968
10.

Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver.

Chen WD, Fu X, Dong B, Wang YD, Shiah S, Moore DD, Huang W.

Hepatology. 2012 Oct;56(4):1499-509. doi: 10.1002/hep.25766.

11.

Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver.

Guo D, Sarkar J, Ahmed MR, Viswakarma N, Jia Y, Yu S, Sambasiva Rao M, Reddy JK.

Biochem Biophys Res Commun. 2006 Aug 25;347(2):485-95. Epub 2006 Jun 30.

PMID:
16828057
12.

Bioinformatic analysis of microRNA networks following the activation of the constitutive androstane receptor (CAR) in mouse liver.

Hao R, Su S, Wan Y, Shen F, Niu B, Coslo DM, Albert I, Han X, Omiecinski CJ.

Biochim Biophys Acta. 2016 Sep;1859(9):1228-1237. doi: 10.1016/j.bbagrm.2016.04.002. Epub 2016 Apr 11.

13.

Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling.

Papa S, Zazzeroni F, Fu YX, Bubici C, Alvarez K, Dean K, Christiansen PA, Anders RA, Franzoso G.

J Clin Invest. 2008 May;118(5):1911-23. doi: 10.1172/JCI33913.

15.

The time point of β-catenin knockout in hepatocytes determines their response to xenobiotic activation of the constitutive androstane receptor.

Ganzenberg K, Singh Y, Braeuning A.

Toxicology. 2013 Jun 7;308:113-21. doi: 10.1016/j.tox.2013.03.019. Epub 2013 Apr 8.

PMID:
23578392
16.

Sex difference in the proliferative response of mouse hepatocytes to treatment with the CAR ligand, TCPOBOP.

Ledda-Columbano GM, Pibiri M, Concas D, Molotzu F, Simbula G, Cossu C, Columbano A.

Carcinogenesis. 2003 Jun;24(6):1059-65. Epub 2003 Apr 24.

PMID:
12807759
17.

Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers.

Rezen T, Tamasi V, Lövgren-Sandblom A, Björkhem I, Meyer UA, Rozman D.

BMC Genomics. 2009 Aug 19;10:384. doi: 10.1186/1471-2164-10-384.

18.

C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia.

Blanco-Bose WE, Murphy MJ, Ehninger A, Offner S, Dubey C, Huang W, Moore DD, Trumpp A.

Hepatology. 2008 Oct;48(4):1302-11. doi: 10.1002/hep.22475.

PMID:
18798339
19.

Constitutive androstane receptor activation evokes the expression of glycolytic genes.

Yarushkin AA, Kazantseva YA, Prokopyeva EA, Markova DN, Pustylnyak YA, Pustylnyak VO.

Biochem Biophys Res Commun. 2016 Sep 23;478(3):1099-105. doi: 10.1016/j.bbrc.2016.08.075. Epub 2016 Aug 13.

PMID:
27530923
20.

The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress.

Maglich JM, Lobe DC, Moore JT.

J Lipid Res. 2009 Mar;50(3):439-45. doi: 10.1194/jlr.M800226-JLR200. Epub 2008 Oct 21.

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