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Erk1 positively regulates osteoclast differentiation and bone resorptive activity.

He Y, Staser K, Rhodes SD, Liu Y, Wu X, Park SJ, Yuan J, Yang X, Li X, Jiang L, Chen S, Yang FC.

PLoS One. 2011;6(9):e24780. doi: 10.1371/journal.pone.0024780.


Saurolactam inhibits osteoclast differentiation and stimulates apoptosis of mature osteoclasts.

Kim MH, Ryu SY, Choi JS, Min YK, Kim SH.

J Cell Physiol. 2009 Dec;221(3):618-28. doi: 10.1002/jcp.21892.


Cell adhesion signaling regulates RANK expression in osteoclast precursors.

Mochizuki A, Takami M, Miyamoto Y, Nakamaki T, Tomoyasu S, Kadono Y, Tanaka S, Inoue T, Kamijo R.

PLoS One. 2012;7(11):e48795. doi: 10.1371/journal.pone.0048795.


Critical role of beta3 integrin in experimental postmenopausal osteoporosis.

Zhao H, Kitaura H, Sands MS, Ross FP, Teitelbaum SL, Novack DV.

J Bone Miner Res. 2005 Dec;20(12):2116-23.


Osteoclast progenitors reside in the peroxisome proliferator-activated receptor γ-expressing bone marrow cell population.

Wei W, Zeve D, Wang X, Du Y, Tang W, Dechow PC, Graff JM, Wan Y.

Mol Cell Biol. 2011 Dec;31(23):4692-705. doi: 10.1128/MCB.05979-11.


ERK Signaling Is Essential for Macrophage Development.

Richardson ET, Shukla S, Nagy N, Boom WH, Beck RC, Zhou L, Landreth GE, Harding CV.

PLoS One. 2015 Oct 7;10(10):e0140064. doi: 10.1371/journal.pone.0140064.


c-Fms signaling mediates neurofibromatosis Type-1 osteoclast gain-in-functions.

He Y, Rhodes SD, Chen S, Wu X, Yuan J, Yang X, Jiang L, Li X, Takahashi N, Xu M, Mohammad KS, Guise TA, Yang FC.

PLoS One. 2012;7(11):e46900. doi: 10.1371/journal.pone.0046900.


Reduction of c-Src activity by substituted 5,7-diphenyl-pyrrolo[2,3-d]-pyrimidines induces osteoclast apoptosis in vivo and in vitro. Involvement of ERK1/2 pathway.

Recchia I, Rucci N, Funari A, Migliaccio S, Taranta A, Longo M, Kneissel M, Susa M, Fabbro D, Teti A.

Bone. 2004 Jan;34(1):65-79.


Sexual Dimorphism in MAPK-Activated Protein Kinase-2 (MK2) Regulation of RANKL-Induced Osteoclastogenesis in Osteoclast Progenitor Subpopulations.

Herbert BA, Valerio MS, Gaestel M, Kirkwood KL.

PLoS One. 2015 May 6;10(5):e0125387. doi: 10.1371/journal.pone.0125387.


Transgenic overexpression of tartrate-resistant acid phosphatase is associated with induction of osteoblast gene expression and increased cortical bone mineral content and density.

Gradin P, Hollberg K, Cassady AI, Lång P, Andersson G.

Cells Tissues Organs. 2012;196(1):68-81. doi: 10.1159/000330806.


Targeted overexpression of osteoactivin in cells of osteoclastic lineage promotes osteoclastic resorption and bone loss in mice.

Sheng MH, Wergedal JE, Mohan S, Amoui M, Baylink DJ, Lau KH.

PLoS One. 2012;7(4):e35280. doi: 10.1371/journal.pone.0035280.


Fibroblast growth factor receptor 1 regulates the differentiation and activation of osteoclasts through Erk1/2 pathway.

Lu X, Su N, Yang J, Huang W, Li C, Zhao L, He Q, Du X, Shen Y, Chen B, Chen L.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):494-9. doi: 10.1016/j.bbrc.2009.09.123.


Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction.

Kobayashi K, Takahashi N, Jimi E, Udagawa N, Takami M, Kotake S, Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, Yasuda H, Morinaga T, Higashio K, Martin TJ, Suda T.

J Exp Med. 2000 Jan 17;191(2):275-86.


Decoy receptor 3 (DcR3) induces osteoclast formation from monocyte/macrophage lineage precursor cells.

Yang CR, Wang JH, Hsieh SL, Wang SM, Hsu TL, Lin WW.

Cell Death Differ. 2004 Jul;11 Suppl 1:S97-107.


Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma.

Breitkreutz I, Raab MS, Vallet S, Hideshima T, Raje N, Chauhan D, Munshi NC, Richardson PG, Anderson KC.

Br J Haematol. 2007 Oct;139(1):55-63.

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