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D,L-sulforaphane-induced apoptosis in human breast cancer cells is regulated by the adapter protein p66Shc.

Sakao K, Singh SV.

J Cell Biochem. 2012 Feb;113(2):599-610. doi: 10.1002/jcb.23386.


p66Shc is indispensable for phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells.

Xiao D, Singh SV.

Cancer Res. 2010 Apr 15;70(8):3150-8. doi: 10.1158/0008-5472.CAN-09-4451. Epub 2010 Mar 30.


Propofol protects against angiotensin II-induced mouse hippocampal HT22 cells apoptosis via inhibition of p66Shc mitochondrial translocation.

Zhu M, Chen J, Wen M, Sun Z, Sun X, Wang J, Miao C.

Neuromolecular Med. 2014 Dec;16(4):772-81. doi: 10.1007/s12017-014-8326-6. Epub 2014 Aug 24.


Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.

Singh SV, Srivastava SK, Choi S, Lew KL, Antosiewicz J, Xiao D, Zeng Y, Watkins SC, Johnson CS, Trump DL, Lee YJ, Xiao H, Herman-Antosiewicz A.

J Biol Chem. 2005 May 20;280(20):19911-24. Epub 2005 Mar 11.


Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens.

Almeida M, Han L, Ambrogini E, Bartell SM, Manolagas SC.

Mol Endocrinol. 2010 Oct;24(10):2030-7. doi: 10.1210/me.2010-0189. Epub 2010 Aug 4.


Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly.

Rajendran P, Delage B, Dashwood WM, Yu TW, Wuth B, Williams DE, Ho E, Dashwood RH.

Mol Cancer. 2011 May 30;10:68. doi: 10.1186/1476-4598-10-68.


Selective inhibition of protein kinase C β2 attenuates the adaptor P66 Shc-mediated intestinal ischemia-reperfusion injury.

Chen Z, Wang G, Zhai X, Hu Y, Gao D, Ma L, Yao J, Tian X.

Cell Death Dis. 2014 Apr 10;5:e1164. doi: 10.1038/cddis.2014.131.


D,L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1.

Choi S, Lew KL, Xiao H, Herman-Antosiewicz A, Xiao D, Brown CK, Singh SV.

Carcinogenesis. 2007 Jan;28(1):151-62. Epub 2006 Aug 18.


Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species.

Hahm ER, Moura MB, Kelley EE, Van Houten B, Shiva S, Singh SV.

PLoS One. 2011;6(8):e23354. doi: 10.1371/journal.pone.0023354. Epub 2011 Aug 10.


p53-p66(shc)/miR-21-Sod2 signaling is critical for the inhibitory effect of betulinic acid on hepatocellular carcinoma.

Yang J, Qiu B, Li X, Zhang H, Liu W.

Toxicol Lett. 2015 Nov 4;238(3):1-10. doi: 10.1016/j.toxlet.2015.07.016. Epub 2015 Jul 26.


Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc.

Pinton P, Rimessi A, Marchi S, Orsini F, Migliaccio E, Giorgio M, Contursi C, Minucci S, Mantovani F, Wieckowski MR, Del Sal G, Pelicci PG, Rizzuto R.

Science. 2007 Feb 2;315(5812):659-63.


p66Shc mediates high-glucose and angiotensin II-induced oxidative stress renal tubular injury via mitochondrial-dependent apoptotic pathway.

Sun L, Xiao L, Nie J, Liu FY, Ling GH, Zhu XJ, Tang WB, Chen WC, Xia YC, Zhan M, Ma MM, Peng YM, Liu H, Liu YH, Kanwar YS.

Am J Physiol Renal Physiol. 2010 Nov;299(5):F1014-25. doi: 10.1152/ajprenal.00414.2010. Epub 2010 Aug 25.


The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.

Natalicchio A, Tortosa F, Labarbuta R, Biondi G, Marrano N, Carchia E, Leonardini A, Cignarelli A, Bugliani M, Marchetti P, Fadini GP, Giorgio M, Avogaro A, Perrini S, Laviola L, Giorgino F.

Diabetologia. 2015 Jun;58(6):1260-71. doi: 10.1007/s00125-015-3563-2. Epub 2015 Mar 26. Erratum in: Diabetologia. 2015 Nov;58(11):2682.


Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species.

Vikram A, Kim YR, Kumar S, Naqvi A, Hoffman TA, Kumar A, Miller FJ Jr, Kim CS, Irani K.

Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2301-9. doi: 10.1161/ATVBAHA.114.304338. Epub 2014 Aug 21.


Cellular responses to cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species.

Xiao D, Powolny AA, Antosiewicz J, Hahm ER, Bommareddy A, Zeng Y, Desai D, Amin S, Herman-Antosiewicz A, Singh SV.

Pharm Res. 2009 Jul;26(7):1729-38. doi: 10.1007/s11095-009-9883-5. Epub 2009 Apr 21.


Oxidized low-density lipoprotein activates p66Shc via lectin-like oxidized low-density lipoprotein receptor-1, protein kinase C-beta, and c-Jun N-terminal kinase kinase in human endothelial cells.

Shi Y, Cosentino F, Camici GG, Akhmedov A, Vanhoutte PM, Tanner FC, Lüscher TF.

Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):2090-7. doi: 10.1161/ATVBAHA.111.229260. Epub 2011 Aug 4.


Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes.

Paneni F, Costantino S, Castello L, Battista R, Capretti G, Chiandotto S, D'Amario D, Scavone G, Villano A, Rustighi A, Crea F, Pitocco D, Lanza G, Volpe M, Del Sal G, Lüscher TF, Cosentino F.

Eur Heart J. 2015 Apr 1;36(13):817-28. doi: 10.1093/eurheartj/ehu179. Epub 2014 May 5.


Involvement of c-Jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by sulforaphane in DU145 prostate cancer cells.

Cho SD, Li G, Hu H, Jiang C, Kang KS, Lee YS, Kim SH, Lu J.

Nutr Cancer. 2005;52(2):213-24.


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