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Items: 1 to 20 of 94

1.

Development and validation of a generic fluorescent methyltransferase activity assay based on the transcreener AMP/GMP assay.

Klink TA, Staeben M, Twesten K, Kopp AL, Kumar M, Dunn RS, Pinchard CA, Kleman-Leyer KM, Klumpp M, Lowery RG.

J Biomol Screen. 2012 Jan;17(1):59-70. doi: 10.1177/1087057111421624. Epub 2011 Sep 28.

2.

Biochemical Assay Development for Histone Methyltransferases Using a Transcreener-Based Assay for S-Adenosylhomocysteine.

Kumar M, Zielinski T, Lowery RG.

Assay Drug Dev Technol. 2015 May;13(4):200-9. doi: 10.1089/adt.2014.609. Epub 2015 Feb 24.

PMID:
25710335
3.

Development and validation of a transcreener assay for detection of AMP- and GMP-producing enzymes.

Staeben M, Kleman-Leyer KM, Kopp AL, Westermeyer TA, Lowery RG.

Assay Drug Dev Technol. 2010 Jun;8(3):344-55. doi: 10.1089/adt.2009.0254.

4.

Fluorescence-based methods for screening writers and readers of histone methyl marks.

Allali-Hassani A, Wasney GA, Siarheyeva A, Hajian T, Arrowsmith CH, Vedadi M.

J Biomol Screen. 2012 Jan;17(1):71-84. doi: 10.1177/1087057111422256. Epub 2011 Oct 4.

PMID:
21972038
5.

A continuous protein methyltransferase (G9a) assay for enzyme activity measurement and inhibitor screening.

Dhayalan A, Dimitrova E, Rathert P, Jeltsch A.

J Biomol Screen. 2009 Oct;14(9):1129-33. doi: 10.1177/1087057109345528. Epub 2009 Sep 4.

PMID:
19734436
6.

A liquid chromatography/mass spectrometry-based generic detection method for biochemical assay and hit discovery of histone methyltransferases.

Li S, Gu XJ, Hao Q, Fan H, Li L, Zhou S, Zhao K, Chan HM, Wang YK.

Anal Biochem. 2013 Dec 15;443(2):214-21. doi: 10.1016/j.ab.2013.08.029. Epub 2013 Sep 7.

PMID:
24018340
7.

A chemiluminescence-based method for identification of histone lysine methyltransferase inhibitors.

Quinn AM, Allali-Hassani A, Vedadi M, Simeonov A.

Mol Biosyst. 2010 May;6(5):782-8. doi: 10.1039/b921912a. Epub 2010 Mar 2.

8.

A coupled fluorescent assay for histone methyltransferases.

Collazo E, Couture JF, Bulfer S, Trievel RC.

Anal Biochem. 2005 Jul 1;342(1):86-92.

PMID:
15958184
9.

Design and synthesis of peptide-MCA substrates for a novel assay of histone methyltransferases and their inhibitors.

Chi H, Takemoto Y, Nsiama TK, Kato T, Nishino N, Ito A, Yoshida M.

Bioorg Med Chem. 2014 Feb 15;22(4):1268-75. doi: 10.1016/j.bmc.2014.01.011. Epub 2014 Jan 21.

PMID:
24486204
10.

Cell-based assays to support the profiling of small molecules with histone methyltransferase and demethylase modulatory activity.

Martinez NJ, Simeonov A.

Drug Discov Today Technol. 2015 Nov;18:9-17. doi: 10.1016/j.ddtec.2015.10.004. Epub 2015 Nov 3. Review.

11.

Development of homogeneous nonradioactive methyltransferase and demethylase assays targeting histone H3 lysine 4.

Gauthier N, Caron M, Pedro L, Arcand M, Blouin J, Labonté A, Normand C, Paquet V, Rodenbrock A, Roy M, Rouleau N, Beaudet L, Padrós J, Rodriguez-Suarez R.

J Biomol Screen. 2012 Jan;17(1):49-58. doi: 10.1177/1087057111416659. Epub 2011 Sep 21.

PMID:
21940714
12.

Screening for compounds that modulate epigenetic regulation of the transcriptome: an overview.

Eglen RM, Reisine T.

J Biomol Screen. 2011 Dec;16(10):1137-52. doi: 10.1177/1087057111417871. Epub 2011 Oct 14. Review.

PMID:
22002420
13.

Assay development for histone methyltransferases.

Horiuchi KY, Eason MM, Ferry JJ, Planck JL, Walsh CP, Smith RF, Howitz KT, Ma H.

Assay Drug Dev Technol. 2013 May;11(4):227-36. doi: 10.1089/adt.2012.480. Epub 2013 Apr 4.

14.

Methyltransferase-Glo: a universal, bioluminescent and homogenous assay for monitoring all classes of methyltransferases.

Hsiao K, Zegzouti H, Goueli SA.

Epigenomics. 2016 Mar;8(3):321-39. doi: 10.2217/epi.15.113. Epub 2016 Mar 7.

15.

Detecting S-adenosyl-L-methionine-induced conformational change of a histone methyltransferase using a homogeneous time-resolved fluorescence-based binding assay.

Lin Y, Fan H, Frederiksen M, Zhao K, Jiang L, Wang Z, Zhou S, Guo W, Gao J, Li S, Harrington E, Meier P, Scheufler C, Xu YC, Atadja P, Lu C, Li E, Gu XJ.

Anal Biochem. 2012 Apr 1;423(1):171-7. doi: 10.1016/j.ab.2012.01.019. Epub 2012 Jan 27.

PMID:
22342622
16.

A high throughput scintillation proximity imaging assay for protein methyltransferases.

Ibanez G, Shum D, Blum G, Bhinder B, Radu C, Antczak C, Luo M, Djaballah H.

Comb Chem High Throughput Screen. 2012 Jun 1;15(5):359-71.

17.

Efficient hit-finding approaches for histone methyltransferases: the key parameters.

Ahrens T, Bergner A, Sheppard D, Hafenbradl D.

J Biomol Screen. 2012 Jan;17(1):85-98. doi: 10.1177/1087057111422823. Epub 2011 Oct 11.

PMID:
21990582
18.

An enzyme-coupled ultrasensitive luminescence assay for protein methyltransferases.

Ibáñez G, McBean JL, Astudillo YM, Luo M.

Anal Biochem. 2010 Jun 15;401(2):203-10. doi: 10.1016/j.ab.2010.03.010. Epub 2010 Mar 12.

PMID:
20227379
19.
20.

TR-FRET cellular assays for interrogating posttranslational modifications of histone H3.

Machleidt T, Robers MB, Hermanson SB, Dudek JM, Bi K.

J Biomol Screen. 2011 Dec;16(10):1236-46. doi: 10.1177/1087057111422943. Epub 2011 Oct 4.

PMID:
21972037

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