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Items: 1 to 20 of 547

1.

Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling.

Urtasun R, Lopategi A, George J, Leung TM, Lu Y, Wang X, Ge X, Fiel MI, Nieto N.

Hepatology. 2012 Feb;55(2):594-608. doi: 10.1002/hep.24701.

2.

Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury.

Arriazu E, Ge X, Leung TM, Magdaleno F, Lopategi A, Lu Y, Kitamura N, Urtasun R, Theise N, Antoine DJ, Nieto N.

Gut. 2017 Jun;66(6):1123-1137. doi: 10.1136/gutjnl-2015-310752. Epub 2016 Jan 27.

3.

Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice.

Mormone E, Lu Y, Ge X, Fiel MI, Nieto N.

Gastroenterology. 2012 Mar;142(3):612-621.e5. doi: 10.1053/j.gastro.2011.11.029. Epub 2011 Dec 1.

4.

Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis.

Son G, Hines IN, Lindquist J, Schrum LW, Rippe RA.

Hepatology. 2009 Nov;50(5):1512-23. doi: 10.1002/hep.23186.

5.

Osteopontin delays resolution of liver fibrosis.

Leung TM, Wang X, Kitamura N, Fiel MI, Nieto N.

Lab Invest. 2013 Oct;93(10):1082-9. doi: 10.1038/labinvest.2013.104. Epub 2013 Sep 2.

6.

Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation.

Seth D, Duly A, Kuo PC, McCaughan GW, Haber PS.

World J Gastroenterol. 2014 Sep 28;20(36):13088-104. doi: 10.3748/wjg.v20.i36.13088.

7.

Osteopontin induces ductular reaction contributing to liver fibrosis.

Wang X, Lopategi A, Ge X, Lu Y, Kitamura N, Urtasun R, Leung TM, Fiel MI, Nieto N.

Gut. 2014 Nov;63(11):1805-18. doi: 10.1136/gutjnl-2013-306373. Epub 2014 Feb 4.

PMID:
24496779
8.

Milk Fat Globule-EGF Factor 8, Secreted by Mesenchymal Stem Cells, Protects Against Liver Fibrosis in Mice.

An SY, Jang YJ, Lim HJ, Han J, Lee J, Lee G, Park JY, Park SY, Kim JH, Do BR, Han C, Park HK, Kim OH, Song MJ, Kim SJ, Kim JH.

Gastroenterology. 2017 Apr;152(5):1174-1186. doi: 10.1053/j.gastro.2016.12.003. Epub 2016 Dec 9.

PMID:
27956229
9.

Heparin-binding epidermal growth factor-like growth factor suppresses experimental liver fibrosis in mice.

Huang G, Besner GE, Brigstock DR.

Lab Invest. 2012 May;92(5):703-12. doi: 10.1038/labinvest.2012.3. Epub 2012 Feb 13.

10.

Hepatic stellate cell is activated by microRNA-181b via PTEN/Akt pathway.

Zheng J, Wu C, Xu Z, Xia P, Dong P, Chen B, Yu F.

Mol Cell Biochem. 2015 Jan;398(1-2):1-9. doi: 10.1007/s11010-014-2199-8. Epub 2014 Aug 23.

PMID:
25148875
11.

Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats.

Paik YH, Yoon YJ, Lee HC, Jung MK, Kang SH, Chung SI, Kim JK, Cho JY, Lee KS, Han KH.

Exp Mol Med. 2011 Jun 30;43(6):341-9.

12.

Activation of Slit2-Robo1 signaling promotes liver fibrosis.

Chang J, Lan T, Li C, Ji X, Zheng L, Gou H, Ou Y, Wu T, Qi C, Zhang Q, Li J, Gu Q, Wen D, Cao L, Qiao L, Ding Y, Wang L.

J Hepatol. 2015 Dec;63(6):1413-20. doi: 10.1016/j.jhep.2015.07.033. Epub 2015 Aug 8.

PMID:
26264936
13.

Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential.

Moles A, Tarrats N, Fernández-Checa JC, Marí M.

Hepatology. 2009 Apr;49(4):1297-307. doi: 10.1002/hep.22753.

14.

Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.

Syn WK, Choi SS, Liaskou E, Karaca GF, Agboola KM, Oo YH, Mi Z, Pereira TA, Zdanowicz M, Malladi P, Chen Y, Moylan C, Jung Y, Bhattacharya SD, Teaberry V, Omenetti A, Abdelmalek MF, Guy CD, Adams DH, Kuo PC, Michelotti GA, Whitington PF, Diehl AM.

Hepatology. 2011 Jan;53(1):106-15. doi: 10.1002/hep.23998. Epub 2010 Oct 21.

15.

Adenoviral delivery of dominant-negative transforming growth factor beta type II receptor up-regulates transcriptional repressor SKI-like oncogene, decreases matrix metalloproteinase 2 in hepatic stellate cell and prevents liver fibrosis in rats.

Marquez-Aguirre A, Sandoval-Rodriguez A, Gonzalez-Cuevas J, Bueno-Topete M, Navarro-Partida J, Arellano-Olivera I, Lucano-Landeros S, Armendariz-Borunda J.

J Gene Med. 2009 Mar;11(3):207-19. doi: 10.1002/jgm.1303.

PMID:
19189315
16.

Loss of discoidin domain receptor 2 promotes hepatic fibrosis after chronic carbon tetrachloride through altered paracrine interactions between hepatic stellate cells and liver-associated macrophages.

Olaso E, Arteta B, Benedicto A, Crende O, Friedman SL.

Am J Pathol. 2011 Dec;179(6):2894-904. doi: 10.1016/j.ajpath.2011.09.002. Epub 2011 Oct 19.

17.

Activation of Insulin-PI3K/Akt-p70S6K Pathway in Hepatic Stellate Cells Contributes to Fibrosis in Nonalcoholic Steatohepatitis.

Cai CX, Buddha H, Castelino-Prabhu S, Zhang Z, Britton RS, Bacon BR, Neuschwander-Tetri BA.

Dig Dis Sci. 2017 Apr;62(4):968-978. doi: 10.1007/s10620-017-4470-9. Epub 2017 Feb 13.

PMID:
28194671
18.

The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation.

Gäbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW, Brenner DA, Rippe RA.

J Biol Chem. 2005 Apr 8;280(14):13374-82. Epub 2005 Jan 26.

19.

Human antigen R contributes to hepatic stellate cell activation and liver fibrosis.

Woodhoo A, Iruarrizaga-Lejarreta M, Beraza N, García-Rodríguez JL, Embade N, Fernández-Ramos D, Martínez-López N, Gutiérrez-De Juan V, Arteta B, Caballeria J, Lu SC, Mato JM, Varela-Rey M, Martínez-Chantar ML.

Hepatology. 2012 Nov;56(5):1870-82. doi: 10.1002/hep.25828. Epub 2012 Oct 9.

20.

Effects and regulation of osteopontin in rat hepatic stellate cells.

Lee SH, Seo GS, Park YN, Yoo TM, Sohn DH.

Biochem Pharmacol. 2004 Dec 15;68(12):2367-78.

PMID:
15548383

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