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Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice.

Zhou J, Neff CP, Liu X, Zhang J, Li H, Smith DD, Swiderski P, Aboellail T, Huang Y, Du Q, Liang Z, Peng L, Akkina R, Rossi JJ.

Mol Ther. 2011 Dec;19(12):2228-38. doi: 10.1038/mt.2011.207. Epub 2011 Sep 27.


An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice.

Neff CP, Zhou J, Remling L, Kuruvilla J, Zhang J, Li H, Smith DD, Swiderski P, Rossi JJ, Akkina R.

Sci Transl Med. 2011 Jan 19;3(66):66ra6. doi: 10.1126/scitranslmed.3001581.


HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model.

Berges BK, Wheat WH, Palmer BE, Connick E, Akkina R.

Retrovirology. 2006 Nov 1;3:76.


A Simple Mouse Model for the Study of Human Immunodeficiency Virus.

Kim KC, Choi BS, Kim KC, Park KH, Lee HJ, Cho YK, Kim SI, Kim SS, Oh YK, Kim YB.

AIDS Res Hum Retroviruses. 2016 Feb;32(2):194-202. doi: 10.1089/AID.2015.0211. Epub 2015 Dec 17.


Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2-/- gammac -/- (RAG-hu) mice.

Berges BK, Akkina SR, Folkvord JM, Connick E, Akkina R.

Virology. 2008 Apr 10;373(2):342-51. doi: 10.1016/j.virol.2007.11.020. Epub 2008 Jan 18.


Latent HIV-1 infection of resting CD4⁺ T cells in the humanized Rag2⁻/⁻ γc⁻/⁻ mouse.

Choudhary SK, Archin NM, Cheema M, Dahl NP, Garcia JV, Margolis DM.

J Virol. 2012 Jan;86(1):114-20. doi: 10.1128/JVI.05590-11. Epub 2011 Oct 19.


Humanized Rag2(-/-)gammac(-/-) (RAG-hu) mice can sustain long-term chronic HIV-1 infection lasting more than a year.

Berges BK, Akkina SR, Remling L, Akkina R.

Virology. 2010 Feb 5;397(1):100-3. doi: 10.1016/j.virol.2009.10.034. Epub 2009 Nov 18.


T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice.

Kumar P, Ban HS, Kim SS, Wu H, Pearson T, Greiner DL, Laouar A, Yao J, Haridas V, Habiro K, Yang YG, Jeong JH, Lee KY, Kim YH, Kim SW, Peipp M, Fey GH, Manjunath N, Shultz LD, Lee SK, Shankar P.

Cell. 2008 Aug 22;134(4):577-86. doi: 10.1016/j.cell.2008.06.034. Epub 2008 Aug 7.


Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge.

Zhou J, Neff CP, Swiderski P, Li H, Smith DD, Aboellail T, Remling-Mulder L, Akkina R, Rossi JJ.

Mol Ther. 2013 Jan;21(1):192-200. doi: 10.1038/mt.2012.226. Epub 2012 Nov 20.


Dual functional RNA nanoparticles containing phi29 motor pRNA and anti-gp120 aptamer for cell-type specific delivery and HIV-1 inhibition.

Zhou J, Shu Y, Guo P, Smith DD, Rossi JJ.

Methods. 2011 Jun;54(2):284-94. doi: 10.1016/j.ymeth.2010.12.039. Epub 2011 Jan 20.


In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4+ T cell levels in humanized mice.

Palmer BE, Neff CP, Lecureux J, Ehler A, Dsouza M, Remling-Mulder L, Korman AJ, Fontenot AP, Akkina R.

J Immunol. 2013 Jan 1;190(1):211-9. doi: 10.4049/jimmunol.1201108. Epub 2012 Dec 3.


Evolution of the HIV-1 env gene in the Rag2-/- gammaC-/- humanized mouse model.

Ince WL, Zhang L, Jiang Q, Arrildt K, Su L, Swanstrom R.

J Virol. 2010 Mar;84(6):2740-52. doi: 10.1128/JVI.02180-09. Epub 2009 Dec 30.


Selective regulation of human immunodeficiency virus-infected CD4(+) lymphocytes by a synthetic immunomodulator leads to potent virus suppression in vitro and in hu-PBL-SCID mice.

Bahr GM, Darcissac EC, Castéran N, Amiel C, Cocude C, Truong MJ, Dewulf J, Capron A, Mouton Y.

J Virol. 2001 Aug;75(15):6941-52.


Humanized Rag1-/- γc-/- mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes.

Akkina R, Berges BK, Palmer BE, Remling L, Neff CP, Kuruvilla J, Connick E, Folkvord J, Gagliardi K, Kassu A, Akkina SR.

PLoS One. 2011;6(6):e20169. doi: 10.1371/journal.pone.0020169. Epub 2011 Jun 14.


A doxycycline-dependent human immunodeficiency virus type 1 replicates in vivo without inducing CD4+ T-cell depletion.

Legrand N, van der Velden GJ, Ho Tsong Fang R, Douaisi M, Weijer K, Das AT, Blom B, Uittenbogaart CH, Berkhout B, Centlivre M.

J Gen Virol. 2012 Sep;93(Pt 9):2017-27. doi: 10.1099/vir.0.042796-0. Epub 2012 May 30.


Arginine rich short linear motif of HIV-1 regulatory proteins inhibits dicer dependent RNA interference.

Ponia SS, Arora S, Kumar B, Banerjea AC.

Retrovirology. 2013 Sep 11;10:97. doi: 10.1186/1742-4690-10-97.


Inhibition of human immunodeficiency virus type 1 replication in vitro in acutely and persistently infected human CD4+ mononuclear cells expressing murine and humanized anti-human immunodeficiency virus type 1 Tat single-chain variable fragment intrabodies.

Mhashilkar AM, LaVecchio J, Eberhardt B, Porter-Brooks J, Boisot S, Dove JH, Pumphrey C, Li X, Weissmahr RN, Ring DB, Ramstedt U, Marasco WA.

Hum Gene Ther. 1999 Jun 10;10(9):1453-67.


Cellular viral rebound after cessation of potent antiretroviral therapy predicted by levels of multiply spliced HIV-1 RNA encoding nef.

Fischer M, Joos B, Hirschel B, Bleiber G, Weber R, Günthard HF; Swiss HIV Cohort Study.

J Infect Dis. 2004 Dec 1;190(11):1979-88. Epub 2004 Nov 3.


PD-1 blockade in chronically HIV-1-infected humanized mice suppresses viral loads.

Seung E, Dudek TE, Allen TM, Freeman GJ, Luster AD, Tager AM.

PLoS One. 2013 Oct 21;8(10):e77780. doi: 10.1371/journal.pone.0077780. eCollection 2013.

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