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Items: 1 to 20 of 76

1.

ABT-737 and/or folate reverse the PDGF-induced alterations in the mitochondrial apoptotic pathway in low-grade glioma patients.

Debien E, Hervouet E, Gautier F, Juin P, Vallette FM, Cartron PF.

Clin Epigenetics. 2011 Aug;2(2):369-381. Epub 2011 May 15.

2.

ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines.

Premkumar DR, Jane EP, DiDomenico JD, Vukmer NA, Agostino NR, Pollack IF.

J Pharmacol Exp Ther. 2012 Jun;341(3):859-72. doi: 10.1124/jpet.112.191536. Epub 2012 Mar 5.

3.

Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B.

Rooswinkel RW, van de Kooij B, Verheij M, Borst J.

Cell Death Dis. 2012 Aug 9;3:e366. doi: 10.1038/cddis.2012.109.

4.

BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets.

Kodama T, Takehara T, Hikita H, Shimizu S, Shigekawa M, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Yin XM, Hayashi N.

J Biol Chem. 2011 Apr 22;286(16):13905-13. doi: 10.1074/jbc.M110.195370. Epub 2011 Mar 2.

5.

Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins.

Tagscherer KE, Fassl A, Campos B, Farhadi M, Kraemer A, Böck BC, Macher-Goeppinger S, Radlwimmer B, Wiestler OD, Herold-Mende C, Roth W.

Oncogene. 2008 Nov 6;27(52):6646-56. doi: 10.1038/onc.2008.259. Epub 2008 Jul 28.

PMID:
18663354
6.

Bcl2L12 with a BH3-like domain in regulating apoptosis and TMZ-induced autophagy: a prospective combination of ABT-737 and TMZ for treating glioma.

Yang MC, Loh JK, Li YY, Huang WS, Chou CH, Cheng JT, Wang YT, Lieu AS, Howng SL, Hong YR, Chou AK.

Int J Oncol. 2015 Mar;46(3):1304-16. doi: 10.3892/ijo.2015.2838. Epub 2015 Jan 13.

PMID:
25586056
7.

Co-administration of ABT-737 and SAHA induces apoptosis, mediated by Noxa upregulation, Bax activation and mitochondrial dysfunction in PTEN-intact malignant human glioma cell lines.

Foster KA, Jane EP, Premkumar DR, Morales A, Pollack IF.

J Neurooncol. 2014 Dec;120(3):459-72. doi: 10.1007/s11060-014-1575-2. Epub 2014 Aug 20.

PMID:
25139025
8.

Drp1 is dispensable for apoptotic cytochrome c release in primed MCF10A and fibroblast cells but affects Bcl-2 antagonist-induced respiratory changes.

Clerc P, Ge SX, Hwang H, Waddell J, Roelofs BA, Karbowski M, Sesaki H, Polster BM.

Br J Pharmacol. 2014 Apr;171(8):1988-99. doi: 10.1111/bph.12515.

9.

Folate supplementation limits the aggressiveness of glioma via the remethylation of DNA repeats element and genes governing apoptosis and proliferation.

Hervouet E, Debien E, Campion L, Charbord J, Menanteau J, Vallette FM, Cartron PF.

Clin Cancer Res. 2009 May 15;15(10):3519-29. doi: 10.1158/1078-0432.CCR-08-2062.

10.

Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737-Mediated Cell Death in Malignant Human Glioma Cell Lines.

Jane EP, Premkumar DR, Cavaleri JM, Sutera PA, Rajasekar T, Pollack IF.

J Pharmacol Exp Ther. 2016 Feb;356(2):354-65. doi: 10.1124/jpet.115.230052. Epub 2015 Nov 19.

11.

Identification of predictive factors of response to the BH3-mimetic molecule ABT-737: an ex vivo experiment in human serous ovarian carcinoma.

Lheureux S, N'Diaye M, Blanc-Fournier C, Dugué AE, Clarisse B, Dutoit S, Giffard F, Abeilard E, Briand M, Labiche A, Grellard JM, Crouet H, Martin S, Joly F, Poulain L.

Int J Cancer. 2015 Mar 1;136(5):E340-50. doi: 10.1002/ijc.29104. Epub 2014 Aug 8.

12.

The Bcl-2 homology domain 3 (BH3)-only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver.

Kodama T, Hikita H, Kawaguchi T, Saito Y, Tanaka S, Shigekawa M, Shimizu S, Li W, Miyagi T, Kanto T, Hiramatsu N, Tatsumi T, Takehara T.

J Biol Chem. 2013 Oct 18;288(42):30009-18. doi: 10.1074/jbc.M112.443093. Epub 2013 Aug 28.

13.

YM-155 potentiates the effect of ABT-737 in malignant human glioma cells via survivin and Mcl-1 downregulation in an EGFR-dependent context.

Jane EP, Premkumar DR, DiDomenico JD, Hu B, Cheng SY, Pollack IF.

Mol Cancer Ther. 2013 Mar;12(3):326-38. doi: 10.1158/1535-7163.MCT-12-0901. Epub 2013 Jan 16.

14.

BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells.

Huang S, Sinicrope FA.

Cancer Res. 2008 Apr 15;68(8):2944-51. doi: 10.1158/0008-5472.CAN-07-2508.

15.

Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner.

Kiprianova I, Remy J, Milosch N, Mohrenz IV, Seifert V, Aigner A, Kögel D.

Neoplasia. 2015 Jul;17(7):564-73. doi: 10.1016/j.neo.2015.07.003.

16.

Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins.

Chipuk JE, Fisher JC, Dillon CP, Kriwacki RW, Kuwana T, Green DR.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20327-32. doi: 10.1073/pnas.0808036105. Epub 2008 Dec 12.

17.

Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax- and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells.

Matsumoto M, Nakajima W, Seike M, Gemma A, Tanaka N.

Biochem Biophys Res Commun. 2016 Apr 29;473(2):490-6. doi: 10.1016/j.bbrc.2016.03.053. Epub 2016 Mar 18.

PMID:
26996126
18.

Pharmacological inhibition of Bcl-2 family members reactivates TRAIL-induced apoptosis in malignant glioma.

Hetschko H, Voss V, Horn S, Seifert V, Prehn JH, Kögel D.

J Neurooncol. 2008 Feb;86(3):265-72. Epub 2007 Oct 9.

PMID:
17924059
19.

Interactions of pro-apoptotic BH3 proteins with anti-apoptotic Bcl-2 family proteins measured in live MCF-7 cells using FLIM FRET.

Liu Q, Leber B, Andrews DW.

Cell Cycle. 2012 Oct 1;11(19):3536-42. doi: 10.4161/cc.21462. Epub 2012 Aug 16.

20.

The Bcl-2 homology domain 3 (BH3) mimetic ABT-737 reveals the dynamic regulation of bad, a proapoptotic protein of the Bcl-2 family, by Bcl-xL.

Ezzoukhry Z, Louandre C, François C, Saidak Z, Godin C, Mazière JC, Galmiche A.

Mol Pharmacol. 2011 Jun;79(6):997-1004. doi: 10.1124/mol.110.070565. Epub 2011 Mar 10.

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