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Items: 1 to 20 of 112

1.

Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse.

Crawford F, Stadinski B, Jin N, Michels A, Nakayama M, Pratt P, Marrack P, Eisenbarth G, Kappler JW.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16729-34. doi: 10.1073/pnas.1113954108. Epub 2011 Sep 26.

2.

Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes.

Zhang L, Crawford F, Yu L, Michels A, Nakayama M, Davidson HW, Kappler JW, Eisenbarth GS.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2656-61. doi: 10.1073/pnas.1323436111. Epub 2014 Feb 3.

3.

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register.

Stadinski BD, Zhang L, Crawford F, Marrack P, Eisenbarth GS, Kappler JW.

Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10978-83. doi: 10.1073/pnas.1006545107. Epub 2010 Jun 1.

5.

Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion.

Mohan JF, Petzold SJ, Unanue ER.

J Exp Med. 2011 Nov 21;208(12):2375-83. doi: 10.1084/jem.20111502. Epub 2011 Nov 7.

6.

N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes.

Jin N, Wang Y, Crawford F, White J, Marrack P, Dai S, Kappler JW.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13318-23. doi: 10.1073/pnas.1517862112. Epub 2015 Oct 9.

7.

Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes.

Yang J, Chow IT, Sosinowski T, Torres-Chinn N, Greenbaum CJ, James EA, Kappler JW, Davidson HW, Kwok WW.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14840-5. doi: 10.1073/pnas.1416864111. Epub 2014 Sep 29.

8.

A peptide binding motif for I-Eg7, the MHC class II molecule that protects E alpha-transgenic nonobese diabetic mice from autoimmune diabetes.

Gregori S, Trembleau S, Penna G, Gallazzi F, Hammer J, Papadopoulos GK, Adorini L.

J Immunol. 1999 Jun 1;162(11):6630-40.

9.

Detection of glutamic acid decarboxylase-activated T cells with I-Ag7 tetramers.

Liu CP, Jiang K, Wu CH, Lee WH, Lin WJ.

Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14596-601.

10.

A novel pathway of presentation by class II-MHC molecules involving peptides or denatured proteins important in autoimmunity.

Mohan JF, Unanue ER.

Mol Immunol. 2013 Sep;55(2):166-8. doi: 10.1016/j.molimm.2012.10.024. Epub 2012 Nov 27. Review.

11.

Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects.

Nakayama M, McDaniel K, Fitzgerald-Miller L, Kiekhaefer C, Snell-Bergeon JK, Davidson HW, Rewers M, Yu L, Gottlieb P, Kappler JW, Michels A.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4429-34. doi: 10.1073/pnas.1502967112. Epub 2015 Mar 23.

13.

Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD mice.

Liu J, Purdy LE, Rabinovitch S, Jevnikar AM, Elliott JF.

Diabetes. 1999 Mar;48(3):469-77.

PMID:
10078545
14.

Peptide-MHC class II dimers as therapeutics to modulate antigen-specific T cell responses in autoimmune diabetes.

Masteller EL, Warner MR, Ferlin W, Judkowski V, Wilson D, Glaichenhaus N, Bluestone JA.

J Immunol. 2003 Nov 15;171(10):5587-95.

15.

Self-peptides that bind with low affinity to the diabetes-associated I-A(g7) molecule readily induce T cell tolerance in non-obese diabetic mice.

Ferlin WG, Mougneau E, Hugues S, Appel H, Jang MH, Cazareth J, Beaudoin L, Schricke C, Lehuen A, Wucherpfennig KW, Glaichenhaus N.

Eur J Immunol. 2004 Oct;34(10):2656-63.

16.
17.

A self MHC class II beta-chain peptide prevents diabetes in nonobese diabetic mice.

Chaturvedi P, Agrawal B, Zechel M, Lee-Chan E, Singh B.

J Immunol. 2000 Jun 15;164(12):6610-20.

18.

Reversal of type 1 diabetes by a new MHC II-peptide chimera: "Single-epitope-mediated suppression" to stabilize a polyclonal autoimmune T-cell process.

Lin M, Stoica-Nazarov C, Surls J, Kehl M, Bona C, Olsen C, Brumeanu TD, Casares S.

Eur J Immunol. 2010 Aug;40(8):2277-88. doi: 10.1002/eji.200940094.

19.

Dual overlapping peptides recognized by insulin peptide B:9-23 T cell receptor AV13S3 T cell clones of the NOD mouse.

Abiru N, Wegmann D, Kawasaki E, Gottlieb P, Simone E, Eisenbarth GS.

J Autoimmun. 2000 May;14(3):231-7.

PMID:
10756085
20.

Reduction of T cell receptor diversity in NOD mice prevents development of type 1 diabetes but not Sjögren's syndrome.

Kern J, Drutel R, Leanhart S, Bogacz M, Pacholczyk R.

PLoS One. 2014 Nov 7;9(11):e112467. doi: 10.1371/journal.pone.0112467. eCollection 2014.

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