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Items: 1 to 20 of 199


Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival.

Maddala R, Chauhan BK, Walker C, Zheng Y, Robinson ML, Lang RA, Rao PV.

Dev Biol. 2011 Dec 1;360(1):30-43. doi: 10.1016/j.ydbio.2011.09.004. Epub 2011 Sep 16.


Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis.

Maddala R, Nagendran T, Lang RA, Morozov A, Rao PV.

Dev Biol. 2015 Oct 1;406(1):74-91. doi: 10.1016/j.ydbio.2015.06.022. Epub 2015 Jul 23.


Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly.

Guo F, Debidda M, Yang L, Williams DA, Zheng Y.

J Biol Chem. 2006 Jul 7;281(27):18652-9. Epub 2006 May 11.


Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development.

Guo F, Cancelas JA, Hildeman D, Williams DA, Zheng Y.

Blood. 2008 Sep 1;112(5):1767-75. doi: 10.1182/blood-2008-01-132068. Epub 2008 Jun 25.


The small GTPase Rac1 regulates auditory hair cell morphogenesis.

Grimsley-Myers CM, Sipe CW, Géléoc GS, Lu X.

J Neurosci. 2009 Dec 16;29(50):15859-69. doi: 10.1523/JNEUROSCI.3998-09.2009.


Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse.

Maddala R, Deng PF, Costello JM, Wawrousek EF, Zigler JS, Rao VP.

Lab Invest. 2004 Jun;84(6):679-92.


Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death.

Cammas L, Wolfe J, Choi SY, Dedhar S, Beggs HE.

Invest Ophthalmol Vis Sci. 2012 May 17;53(6):3067-81. doi: 10.1167/iovs.11-9128.


Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons.

Chen L, Liao G, Waclaw RR, Burns KA, Linquist D, Campbell K, Zheng Y, Kuan CY.

J Neurosci. 2007 Apr 4;27(14):3884-93.


Differential requirement for beta-catenin in epithelial and fiber cells during lens development.

Cain S, Martinez G, Kokkinos MI, Turner K, Richardson RJ, Abud HE, Huelsken J, Robinson ML, de Iongh RU.

Dev Biol. 2008 Sep 15;321(2):420-33. doi: 10.1016/j.ydbio.2008.07.002. Epub 2008 Jul 9.


Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival.

Maddala R, Reneker LW, Pendurthi B, Rao PV.

Dev Biol. 2008 Mar 1;315(1):217-31. doi: 10.1016/j.ydbio.2007.12.039. Epub 2008 Jan 3.


GEFT, A Rho family guanine nucleotide exchange factor, regulates lens differentiation through a Rac1-mediated mechanism.

Mitchell DC, Bryan BA, Liu L, Hu XH, Huang XQ, Ji WK, Chen PC, Hu WF, Liu JP, Zhang J, Liu M, Li DW.

Curr Mol Med. 2011 Aug;11(6):465-80.


Redundant functions of Rac GTPases in inner ear morphogenesis.

Grimsley-Myers CM, Sipe CW, Wu DK, Lu X.

Dev Biol. 2012 Feb 15;362(2):172-86. doi: 10.1016/j.ydbio.2011.12.008. Epub 2011 Dec 11.


Developmental expression of three small GTPases in the mouse eye.

Mitchell DC, Bryan BA, Liu JP, Liu WB, Zhang L, Qu J, Zhou X, Liu M, Li DW.

Mol Vis. 2007 Jul 13;13:1144-53.


Morphology and organization of posterior fiber ends during migration.

Al-Ghoul KJ, Kuszak JR, Lu JY, Owens MJ.

Mol Vis. 2003 Apr 16;9:119-28.


Rac1-dependent cell cycle exit of MGE precursors and GABAergic interneuron migration to the cortex.

Vidaki M, Tivodar S, Doulgeraki K, Tybulewicz V, Kessaris N, Pachnis V, Karagogeos D.

Cereb Cortex. 2012 Mar;22(3):680-92. doi: 10.1093/cercor/bhr145. Epub 2011 Jun 20. Erratum in: Cereb Cortex. 2013 Apr;23(4):1003.


The rho GTPase Rac1 is required for proliferation and survival of progenitors in the developing forebrain.

Leone DP, Srinivasan K, Brakebusch C, McConnell SK.

Dev Neurobiol. 2010 Aug;70(9):659-78. doi: 10.1002/dneu.20804.


Rac1 and Rac2 regulate macrophage morphology but are not essential for migration.

Wheeler AP, Wells CM, Smith SD, Vega FM, Henderson RB, Tybulewicz VL, Ridley AJ.

J Cell Sci. 2006 Jul 1;119(Pt 13):2749-57. Epub 2006 Jun 13.


Requirement for TGFbeta receptor signaling during terminal lens fiber differentiation.

de Iongh RU, Lovicu FJ, Overbeek PA, Schneider MD, Joya J, Hardeman ED, McAvoy JW.

Development. 2001 Oct;128(20):3995-4010.


Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.

Martinez G, Wijesinghe M, Turner K, Abud HE, Taketo MM, Noda T, Robinson ML, de Iongh RU.

Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4794-806. doi: 10.1167/iovs.09-3567. Epub 2009 Jun 10.


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