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Human cytomegalovirus induces multiple means to combat reactive oxygen species.

Tilton C, Clippinger AJ, Maguire T, Alwine JC.

J Virol. 2011 Dec;85(23):12585-93. doi: 10.1128/JVI.05572-11. Epub 2011 Sep 21.


Digitoxin Suppresses Human Cytomegalovirus Replication via Na+, K+/ATPase α1 Subunit-Dependent AMP-Activated Protein Kinase and Autophagy Activation.

Mukhopadhyay R, Venkatadri R, Katsnelson J, Arav-Boger R.

J Virol. 2018 Feb 26;92(6). pii: e01861-17. doi: 10.1128/JVI.01861-17. Print 2018 Mar 15.


Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells.

Chen L, Xu B, Liu L, Luo Y, Yin J, Zhou H, Chen W, Shen T, Han X, Huang S.

Lab Invest. 2010 May;90(5):762-73. doi: 10.1038/labinvest.2010.36. Epub 2010 Feb 8.


Multi-mechanisms are involved in reactive oxygen species regulation of mTORC1 signaling.

Li M, Zhao L, Liu J, Liu A, Jia C, Ma D, Jiang Y, Bai X.

Cell Signal. 2010 Oct;22(10):1469-76. doi: 10.1016/j.cellsig.2010.05.015.


Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes.

Kudchodkar SB, Yu Y, Maguire TG, Alwine JC.

Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14182-7. Epub 2006 Sep 7.


Glutathione and antioxidant enzymes serve complementary roles in protecting activated hepatic stellate cells against hydrogen peroxide-induced cell death.

Dunning S, Ur Rehman A, Tiebosch MH, Hannivoort RA, Haijer FW, Woudenberg J, van den Heuvel FA, Buist-Homan M, Faber KN, Moshage H.

Biochim Biophys Acta. 2013 Dec;1832(12):2027-34. doi: 10.1016/j.bbadis.2013.07.008. Epub 2013 Jul 16.


The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection.

Clippinger AJ, Maguire TG, Alwine JC.

J Virol. 2011 Apr;85(8):3930-9. doi: 10.1128/JVI.01913-10. Epub 2011 Feb 9.


Human cytomegalovirus infection maintains mTOR activity and its perinuclear localization during amino acid deprivation.

Clippinger AJ, Maguire TG, Alwine JC.

J Virol. 2011 Sep;85(18):9369-76. doi: 10.1128/JVI.05102-11. Epub 2011 Jul 6.


Hydrogen Peroxide Induce Human Cytomegalovirus Replication through the Activation of p38-MAPK Signaling Pathway.

Xiao J, Deng J, Lv L, Kang Q, Ma P, Yan F, Song X, Gao B, Zhang Y, Xu J.

Viruses. 2015 Jun 4;7(6):2816-33. doi: 10.3390/v7062748.


Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1.

Tripathi DN, Chowdhury R, Trudel LJ, Tee AR, Slack RS, Walker CL, Wogan GN.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):E2950-7. doi: 10.1073/pnas.1307736110. Epub 2013 Jul 22.


Tuberous Sclerosis Complex Protein 2-Independent Activation of mTORC1 by Human Cytomegalovirus pUL38.

Bai Y, Xuan B, Liu H, Zhong J, Yu D, Qian Z.

J Virol. 2015 Aug;89(15):7625-35. doi: 10.1128/JVI.01027-15. Epub 2015 May 13.


Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK.

Zhou H, Shang C, Wang M, Shen T, Kong L, Yu C, Ye Z, Luo Y, Liu L, Li Y, Huang S.

Biochem Pharmacol. 2016 Sep 15;116:39-50. doi: 10.1016/j.bcp.2016.07.005. Epub 2016 Jul 7.


The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1-p70S6K-RPS6 signaling.

Calamaras TD, Lee C, Lan F, Ido Y, Siwik DA, Colucci WS.

Free Radic Biol Med. 2015 May;82:137-46. doi: 10.1016/j.freeradbiomed.2015.01.007. Epub 2015 Jan 21.


Inflammasome, mTORC1 activation, and metabolic derangement contribute to the susceptibility of diabetics to infections.

Krakauer T.

Med Hypotheses. 2015 Dec;85(6):997-1001. doi: 10.1016/j.mehy.2015.08.019. Epub 2015 Sep 6.


Transforming Growth Factor β1-induced Apoptosis in Podocytes via the Extracellular Signal-regulated Kinase-Mammalian Target of Rapamycin Complex 1-NADPH Oxidase 4 Axis.

Das R, Xu S, Nguyen TT, Quan X, Choi SK, Kim SJ, Lee EY, Cha SK, Park KS.

J Biol Chem. 2015 Dec 25;290(52):30830-42. doi: 10.1074/jbc.M115.703116. Epub 2015 Nov 12.


Belinostat-induced apoptosis and growth inhibition in pancreatic cancer cells involve activation of TAK1-AMPK signaling axis.

Wang B, Wang XB, Chen LY, Huang L, Dong RZ.

Biochem Biophys Res Commun. 2013 Jul 19;437(1):1-6. doi: 10.1016/j.bbrc.2013.05.090. Epub 2013 Jun 4.


Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells.

Aryal P, Kim K, Park PH, Ham S, Cho J, Song K.

FEBS J. 2014 Oct;281(20):4644-58. doi: 10.1111/febs.12969. Epub 2014 Sep 11.


AMPK-mediated inhibition of mTOR kinase is circumvented during immediate-early times of human cytomegalovirus infection.

Kudchodkar SB, Del Prete GQ, Maguire TG, Alwine JC.

J Virol. 2007 Apr;81(7):3649-51. Epub 2007 Jan 10.


Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replication.

Moorman NJ, Shenk T.

J Virol. 2010 May;84(10):5260-9. doi: 10.1128/JVI.02733-09. Epub 2010 Feb 24.

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