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Mitochondrial quality control by the ubiquitin-proteasome system.

Taylor EB, Rutter J.

Biochem Soc Trans. 2011 Oct;39(5):1509-13. doi: 10.1042/BST0391509. Review.


Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation.

Karbowski M, Youle RJ.

Curr Opin Cell Biol. 2011 Aug;23(4):476-82. doi: 10.1016/ Epub 2011 Jun 24. Review.


A stress-responsive system for mitochondrial protein degradation.

Heo JM, Livnat-Levanon N, Taylor EB, Jones KT, Dephoure N, Ring J, Xie J, Brodsky JL, Madeo F, Gygi SP, Ashrafi K, Glickman MH, Rutter J.

Mol Cell. 2010 Nov 12;40(3):465-80. doi: 10.1016/j.molcel.2010.10.021.


Outer mitochondrial membrane protein degradation by the proteasome.

Neutzner A, Youle RJ, Karbowski M.

Novartis Found Symp. 2007;287:4-14; discussion 14-20. Review.


Ubx2 links the Cdc48 complex to ER-associated protein degradation.

Neuber O, Jarosch E, Volkwein C, Walter J, Sommer T.

Nat Cell Biol. 2005 Oct;7(10):993-8. Epub 2005 Sep 18.


Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy.

Chan NC, Salazar AM, Pham AH, Sweredoski MJ, Kolawa NJ, Graham RL, Hess S, Chan DC.

Hum Mol Genet. 2011 May 1;20(9):1726-37. doi: 10.1093/hmg/ddr048. Epub 2011 Feb 4.


The Cdc48-Vms1 complex maintains 26S proteasome architecture.

Tran JR, Brodsky JL.

Biochem J. 2014 Mar 15;458(3):459-67. doi: 10.1042/BJ20131161.


A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway.

Sá-Moura B, Funakoshi M, Tomko RJ Jr, Dohmen RJ, Wu Z, Peng J, Hochstrasser M.

J Biol Chem. 2013 Nov 22;288(47):33682-96. doi: 10.1074/jbc.M113.521088. Epub 2013 Oct 11.


Create and preserve: proteostasis in development and aging is governed by Cdc48/p97/VCP.

Franz A, Ackermann L, Hoppe T.

Biochim Biophys Acta. 2014 Jan;1843(1):205-15. doi: 10.1016/j.bbamcr.2013.03.031. Epub 2013 Apr 10. Review.


Hsp70 targets a cytoplasmic quality control substrate to the San1p ubiquitin ligase.

Guerriero CJ, Weiberth KF, Brodsky JL.

J Biol Chem. 2013 Jun 21;288(25):18506-20. doi: 10.1074/jbc.M113.475905. Epub 2013 May 7.


Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin.

Tanaka A, Cleland MM, Xu S, Narendra DP, Suen DF, Karbowski M, Youle RJ.

J Cell Biol. 2010 Dec 27;191(7):1367-80. doi: 10.1083/jcb.201007013. Epub 2010 Dec 20.


Doa1 targets ubiquitinated substrates for mitochondria-associated degradation.

Wu X, Li L, Jiang H.

J Cell Biol. 2016 Apr 11;213(1):49-63. doi: 10.1083/jcb.201510098. Epub 2016 Apr 4.


A Cdc48 "Retrochaperone" Function Is Required for the Solubility of Retrotranslocated, Integral Membrane Endoplasmic Reticulum-associated Degradation (ERAD-M) Substrates.

Neal S, Mak R, Bennett EJ, Hampton R.

J Biol Chem. 2017 Feb 24;292(8):3112-3128. doi: 10.1074/jbc.M116.770610. Epub 2017 Jan 11.


Ubiquitin-proteasome-dependent degradation of a mitofusin, a critical regulator of mitochondrial fusion.

Cohen MM, Leboucher GP, Livnat-Levanon N, Glickman MH, Weissman AM.

Mol Biol Cell. 2008 Jun;19(6):2457-64. doi: 10.1091/mbc.E08-02-0227. Epub 2008 Mar 19.


The requirement for Cdc48/p97 in nuclear protein quality control degradation depends on the substrate and correlates with substrate insolubility.

Gallagher PS, Clowes Candadai SV, Gardner RG.

J Cell Sci. 2014 May 1;127(Pt 9):1980-91. doi: 10.1242/jcs.141838. Epub 2014 Feb 25.


Degradation Signals for Ubiquitin-Proteasome Dependent Cytosolic Protein Quality Control (CytoQC) in Yeast.

Maurer MJ, Spear ED, Yu AT, Lee EJ, Shahzad S, Michaelis S.

G3 (Bethesda). 2016 Jul 7;6(7):1853-66. doi: 10.1534/g3.116.027953.


AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation.

Zhong X, Shen Y, Ballar P, Apostolou A, Agami R, Fang S.

J Biol Chem. 2004 Oct 29;279(44):45676-84. Epub 2004 Aug 24.


Parkin uses the UPS to ship off dysfunctional mitochondria.

Chan NC, Chan DC.

Autophagy. 2011 Jul;7(7):771-2. Epub 2011 Jul 1.


On the linkage between the ubiquitin-proteasome system and the mitochondria.

Lehmann G, Udasin RG, Ciechanover A.

Biochem Biophys Res Commun. 2016 Apr 22;473(1):80-86. doi: 10.1016/j.bbrc.2016.03.055. Epub 2016 Mar 18.


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