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Items: 1 to 20 of 65

1.

Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategies.

Simister PC, Feller SM.

Mol Biosyst. 2012 Jan;8(1):33-46. doi: 10.1039/c1mb05272a. Epub 2011 Sep 20. Review.

PMID:
21935523
3.

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.

Brummer T, Larance M, Herrera Abreu MT, Lyons RJ, Timpson P, Emmerich CH, Fleuren ED, Lehrbach GM, Schramek D, Guilhaus M, James DE, Daly RJ.

EMBO J. 2008 Sep 3;27(17):2305-16.

4.

The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling.

Sármay G, Angyal A, Kertész A, Maus M, Medgyesi D.

Immunol Lett. 2006 Apr 15;104(1-2):76-82. Epub 2005 Dec 13. Review.

PMID:
16386802
5.

Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.

Nioche P, Liu WQ, Broutin I, Charbonnier F, Latreille MT, Vidal M, Roques B, Garbay C, Ducruix A.

J Mol Biol. 2002 Feb 1;315(5):1167-77.

PMID:
11827484
6.
7.

A Grb2-associated docking protein in EGF- and insulin-receptor signalling.

Holgado-Madruga M, Emlet DR, Moscatello DK, Godwin AK, Wong AJ.

Nature. 1996 Feb 8;379(6565):560-4.

PMID:
8596638
8.

GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2.

Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS.

J Biol Chem. 2003 Sep 5;278(36):34641-53. Epub 2003 Jun 19.

9.

Protein-protein interactions: a simple strategy to identify binding sites and peptide antagonists.

Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D.

Chem Biol Drug Des. 2009 May;73(5):483-93. doi: 10.1111/j.1747-0285.2009.00805.x.

PMID:
19366357
10.

How to Grb2 a Gab.

Wöhrle FU, Daly RJ, Brummer T.

Structure. 2009 Jun 10;17(6):779-81. doi: 10.1016/j.str.2009.05.003.

11.

SH2 and SH3-containing adaptor proteins: redundant or independent mediators of intracellular signal transduction.

Birge RB, Knudsen BS, Besser D, Hanafusa H.

Genes Cells. 1996 Jul;1(7):595-613. Review.

12.

Gab docking proteins in cardiovascular disease, cancer, and inflammation.

Nakaoka Y, Komuro I.

Int J Inflam. 2013;2013:141068. doi: 10.1155/2013/141068. Epub 2013 Jan 22.

14.

The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif.

Lewitzky M, Kardinal C, Gehring NH, Schmidt EK, Konkol B, Eulitz M, Birchmeier W, Schaeper U, Feller SM.

Oncogene. 2001 Mar 1;20(9):1052-62.

15.

Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1.

Qiu M, Hua S, Agrawal M, Li G, Cai J, Chan E, Zhou H, Luo Y, Liu M.

Biochem Biophys Res Commun. 1998 Dec 18;253(2):443-7.

PMID:
9878555
18.

Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain.

Lock LS, Frigault MM, Saucier C, Park M.

J Biol Chem. 2003 Aug 8;278(32):30083-90. Epub 2003 May 22.

19.

Engagement of Gab1 and Gab2 in erythropoietin signaling.

Wickrema A, Uddin S, Sharma A, Chen F, Alsayed Y, Ahmad S, Sawyer ST, Krystal G, Yi T, Nishada K, Hibi M, Hirano T, Platanias LC.

J Biol Chem. 1999 Aug 27;274(35):24469-74.

20.

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