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Items: 1 to 20 of 153

1.

Homocysteine promotes human endothelial cell dysfunction via site-specific epigenetic regulation of p66shc.

Kim CS, Kim YR, Naqvi A, Kumar S, Hoffman TA, Jung SB, Kumar A, Jeon BH, McNamara DM, Irani K.

Cardiovasc Res. 2011 Dec 1;92(3):466-75. doi: 10.1093/cvr/cvr250. Epub 2011 Sep 20.

2.

Epigenetic upregulation of p66shc mediates low-density lipoprotein cholesterol-induced endothelial cell dysfunction.

Kim YR, Kim CS, Naqvi A, Kumar A, Kumar S, Hoffman TA, Irani K.

Am J Physiol Heart Circ Physiol. 2012 Jul 15;303(2):H189-96. doi: 10.1152/ajpheart.01218.2011. Epub 2012 Jun 1.

3.

Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species.

Vikram A, Kim YR, Kumar S, Naqvi A, Hoffman TA, Kumar A, Miller FJ Jr, Kim CS, Irani K.

Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2301-9. doi: 10.1161/ATVBAHA.114.304338. Epub 2014 Aug 21.

4.

CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation.

Nagar H, Jung SB, Kwon SK, Park JB, Shong M, Song HJ, Jeon BH, Irani K, Kim CS.

PLoS One. 2014 Jun 6;9(6):e98670. doi: 10.1371/journal.pone.0098670. eCollection 2014.

5.

Transcriptional repression of Kruppel like factor-2 by the adaptor protein p66shc.

Kumar A, Hoffman TA, Dericco J, Naqvi A, Jain MK, Irani K.

FASEB J. 2009 Dec;23(12):4344-52. doi: 10.1096/fj.09-138743. Epub 2009 Aug 20.

6.

Dual role of endothelial nitric oxide synthase in oxidized LDL-induced, p66Shc-mediated oxidative stress in cultured human endothelial cells.

Shi Y, Lüscher TF, Camici GG.

PLoS One. 2014 Sep 23;9(9):e107787. doi: 10.1371/journal.pone.0107787. eCollection 2014.

7.

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes.

Paneni F, Costantino S, Castello L, Battista R, Capretti G, Chiandotto S, D'Amario D, Scavone G, Villano A, Rustighi A, Crea F, Pitocco D, Lanza G, Volpe M, Del Sal G, Lüscher TF, Cosentino F.

Eur Heart J. 2015 Apr 1;36(13):817-28. doi: 10.1093/eurheartj/ehu179. Epub 2014 May 5.

PMID:
24801072
8.

Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction.

Zhou S, Chen HZ, Wan YZ, Zhang QJ, Wei YS, Huang S, Liu JJ, Lu YB, Zhang ZQ, Yang RF, Zhang R, Cai H, Liu DP, Liang CC.

Circ Res. 2011 Sep 2;109(6):639-48. doi: 10.1161/CIRCRESAHA.111.243592. Epub 2011 Jul 21.

9.

p53 impairs endothelium-dependent vasomotor function through transcriptional upregulation of p66shc.

Kim CS, Jung SB, Naqvi A, Hoffman TA, DeRicco J, Yamamori T, Cole MP, Jeon BH, Irani K.

Circ Res. 2008 Dec 5;103(12):1441-50. doi: 10.1161/CIRCRESAHA.108.181644. Epub 2008 Nov 6.

10.

The expression of p66shc in peripheral blood monocytes is increased in patients with coronary heart disease and correlated with endothelium-dependent vasodilatation.

Miao Q, Wang Q, Dong L, Wang Y, Tan Y, Zhang X.

Heart Vessels. 2015 Jul;30(4):451-7. doi: 10.1007/s00380-014-0497-4. Epub 2014 Mar 28.

PMID:
24676406
11.

Nitric oxide, oxidative stress, and p66Shc interplay in diabetic endothelial dysfunction.

Magenta A, Greco S, Capogrossi MC, Gaetano C, Martelli F.

Biomed Res Int. 2014;2014:193095. doi: 10.1155/2014/193095. Epub 2014 Mar 5. Review.

12.

Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells.

Kida T, Tsubosaka Y, Hori M, Ozaki H, Murata T.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1663-9. doi: 10.1161/ATVBAHA.113.301565. Epub 2013 Apr 25.

13.

TNFα signals via p66(Shc) to induce E-Selectin, promote leukocyte transmigration and enhance permeability in human endothelial cells.

Laviola L, Orlando MR, Incalza MA, Caccioppoli C, Melchiorre M, Leonardini A, Cignarelli A, Tortosa F, Labarbuta R, Martemucci S, Pacelli C, Cocco T, Perrini S, Natalicchio A, Giorgino F.

PLoS One. 2013 Dec 2;8(12):e81930. doi: 10.1371/journal.pone.0081930. eCollection 2013.

14.

Epigallocatechin-3-gallate inhibits homocysteine-induced apoptosis of endothelial cells by demethylation of the DDAH2 gene.

Zhang BK, Lai YQ, Niu PP, Zhao M, Jia SJ.

Planta Med. 2013 Dec;79(18):1715-9. doi: 10.1055/s-0033-1351017. Epub 2013 Nov 15.

PMID:
24243545
15.

Epigenetic modifiers exert renal toxicity through induction of p66shc.

Arany I, Clark JS, Ember I, Juncos LA.

Anticancer Res. 2011 Oct;31(10):3267-71.

PMID:
21965735
16.

DNA methylation of the p66Shc promoter is decreased in placental tissue from women delivering intrauterine growth restricted neonates.

Tzschoppe A, Doerr H, Rascher W, Goecke T, Beckmann M, Schild R, Struwe E, Geisel J, Jung H, Dötsch J.

Prenat Diagn. 2013 May;33(5):484-91. doi: 10.1002/pd.4096. Epub 2013 Mar 26.

PMID:
23529764
17.

Homocysteine upregulates vascular cell adhesion molecule-1 expression in cultured human aortic endothelial cells and enhances monocyte adhesion.

Silverman MD, Tumuluri RJ, Davis M, Lopez G, Rosenbaum JT, Lelkes PI.

Arterioscler Thromb Vasc Biol. 2002 Apr 1;22(4):587-92.

18.

Chronic nicotine exposure augments renal oxidative stress and injury through transcriptional activation of p66shc.

Arany I, Clark J, Reed DK, Juncos LA.

Nephrol Dial Transplant. 2013 Jun;28(6):1417-25. doi: 10.1093/ndt/gfs596. Epub 2013 Jan 16.

19.

Decreased p66Shc promoter methylation in patients with end-stage renal disease.

Geisel J, Schorr H, Heine GH, Bodis M, Hübner U, Knapp JP, Herrmann W.

Clin Chem Lab Med. 2007;45(12):1764-70.

PMID:
18067454
20.

The role of endoplasmic reticulum stress in endothelial dysfunction induced by homocysteine thiolactone.

Wu S, Gao X, Yang S, Meng M, Yang X, Ge B.

Fundam Clin Pharmacol. 2015 Jun;29(3):252-9. doi: 10.1111/fcp.12101. Epub 2015 Feb 27.

PMID:
25623775

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