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The overlapping host responses to bacterial cyclic dinucleotides.

Abdul-Sater AA, Grajkowski A, Erdjument-Bromage H, Plumlee C, Levi A, Schreiber MT, Lee C, Shuman H, Beaucage SL, Schindler C.

Microbes Infect. 2012 Feb;14(2):188-97. doi: 10.1016/j.micinf.2011.09.002. Epub 2011 Sep 10.


Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome.

Abdul-Sater AA, Tattoli I, Jin L, Grajkowski A, Levi A, Koller BH, Allen IC, Beaucage SL, Fitzgerald KA, Ting JP, Cambier JC, Girardin SE, Schindler C.

EMBO Rep. 2013 Oct;14(10):900-6. doi: 10.1038/embor.2013.132. Epub 2013 Sep 6.


The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides.

Sauer JD, Sotelo-Troha K, von Moltke J, Monroe KM, Rae CS, Brubaker SW, Hyodo M, Hayakawa Y, Woodward JJ, Portnoy DA, Vance RE.

Infect Immun. 2011 Feb;79(2):688-94. doi: 10.1128/IAI.00999-10. Epub 2010 Nov 22.


Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila.

Fontana MF, Banga S, Barry KC, Shen X, Tan Y, Luo ZQ, Vance RE.

PLoS Pathog. 2011 Feb;7(2):e1001289. doi: 10.1371/journal.ppat.1001289. Epub 2011 Feb 17.


Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila.

Monroe KM, McWhirter SM, Vance RE.

PLoS Pathog. 2009 Nov;5(11):e1000665. doi: 10.1371/journal.ppat.1000665. Epub 2009 Nov 20.


A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP.

Hisert KB, MacCoss M, Shiloh MU, Darwin KH, Singh S, Jones RA, Ehrt S, Zhang Z, Gaffney BL, Gandotra S, Holden DW, Murray D, Nathan C.

Mol Microbiol. 2005 Jun;56(5):1234-45.


The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response.

Parvatiyar K, Zhang Z, Teles RM, Ouyang S, Jiang Y, Iyer SS, Zaver SA, Schenk M, Zeng S, Zhong W, Liu ZJ, Modlin RL, Liu YJ, Cheng G.

Nat Immunol. 2012 Dec;13(12):1155-61. doi: 10.1038/ni.2460. Epub 2012 Nov 11.


A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis.

Dey B, Dey RJ, Cheung LS, Pokkali S, Guo H, Lee JH, Bishai WR.

Nat Med. 2015 Apr;21(4):401-6. doi: 10.1038/nm.3813. Epub 2015 Mar 2.


MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP.

Jin L, Hill KK, Filak H, Mogan J, Knowles H, Zhang B, Perraud AL, Cambier JC, Lenz LL.

J Immunol. 2011 Sep 1;187(5):2595-601. doi: 10.4049/jimmunol.1100088. Epub 2011 Aug 3.


Global cellular changes induced by Legionella pneumophila infection of bone marrow-derived macrophages.

Fortier A, Faucher SP, Diallo K, Gros P.

Immunobiology. 2011 Dec;216(12):1274-85. doi: 10.1016/j.imbio.2011.06.008. Epub 2011 Jun 30.


Cyclic diguanylate regulates Vibrio cholerae virulence gene expression.

Tischler AD, Camilli A.

Infect Immun. 2005 Sep;73(9):5873-82.


The human apoptosis inhibitor NAIP induces pyroptosis in macrophages infected with Legionella pneumophila.

Katagiri N, Shobuike T, Chang B, Kukita A, Miyamoto H.

Microbes Infect. 2012 Nov;14(13):1123-32. doi: 10.1016/j.micinf.2012.03.006. Epub 2012 Mar 28.


Pore formation triggered by Legionella spp. is an Nlrc4 inflammasome-dependent host cell response that precedes pyroptosis.

Silveira TN, Zamboni DS.

Infect Immun. 2010 Mar;78(3):1403-13. doi: 10.1128/IAI.00905-09. Epub 2010 Jan 4.


The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy.

Watson RO, Bell SL, MacDuff DA, Kimmey JM, Diner EJ, Olivas J, Vance RE, Stallings CL, Virgin HW, Cox JS.

Cell Host Microbe. 2015 Jun 10;17(6):811-819. doi: 10.1016/j.chom.2015.05.004. Epub 2015 Jun 2.


Interferon-gamma reverses the evasion of Birc1e/Naip5 gene mediated murine macrophage immunity by Legionella pneumophila mutant lacking flagellin.

Akamine M, Higa F, Haranaga S, Tateyama M, Mori N, Heuner K, Fujita J.

Microbiol Immunol. 2007;51(3):279-87.


STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection.

Barker JR, Koestler BJ, Carpenter VK, Burdette DL, Waters CM, Vance RE, Valdivia RH.

MBio. 2013 Apr 30;4(3):e00018-13. doi: 10.1128/mBio.00018-13.


H-NOX regulation of c-di-GMP metabolism and biofilm formation in Legionella pneumophila.

Carlson HK, Vance RE, Marletta MA.

Mol Microbiol. 2010 Aug;77(4):930-42. doi: 10.1111/j.1365-2958.2010.07259.x. Epub 2010 Jun 21.


The protein SdhA maintains the integrity of the Legionella-containing vacuole.

Creasey EA, Isberg RR.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3481-6. doi: 10.1073/pnas.1121286109. Epub 2012 Jan 30.


A chemosensory system that regulates biofilm formation through modulation of cyclic diguanylate levels.

Hickman JW, Tifrea DF, Harwood CS.

Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14422-7. Epub 2005 Sep 26.

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