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The neuroprotective effect of a specific P2X₇ receptor antagonist derives from its ability to inhibit assembly of the NLRP3 inflammasome in glial cells.

Murphy N, Cowley TR, Richardson JC, Virley D, Upton N, Walter D, Lynch MA.

Brain Pathol. 2012 May;22(3):295-306. doi: 10.1111/j.1750-3639.2011.00531.x. Epub 2011 Oct 27.


P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation.

Hung SC, Choi CH, Said-Sadier N, Johnson L, Atanasova KR, Sellami H, Yilmaz Ö, Ojcius DM.

PLoS One. 2013 Jul 25;8(7):e70210. doi: 10.1371/journal.pone.0070210. Print 2013.


Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages.

Budai MM, Varga A, Milesz S, Tőzsér J, Benkő S.

Mol Immunol. 2013 Dec;56(4):471-9. doi: 10.1016/j.molimm.2013.05.005. Epub 2013 Aug 1.


Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway.

Niemi K, Teirilä L, Lappalainen J, Rajamäki K, Baumann MH, Öörni K, Wolff H, Kovanen PT, Matikainen S, Eklund KK.

J Immunol. 2011 Jun 1;186(11):6119-28. doi: 10.4049/jimmunol.1002843. Epub 2011 Apr 20.


Glial uptake of amyloid beta induces NLRP3 inflammasome formation via cathepsin-dependent degradation of NLRP10.

Murphy N, Grehan B, Lynch MA.

Neuromolecular Med. 2014 Mar;16(1):205-15. doi: 10.1007/s12017-013-8274-6. Epub 2013 Nov 7.


Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the adenosine triphosphate-induced cytokine release from macrophages.

Gicquel T, Victoni T, Fautrel A, Robert S, Gleonnec F, Guezingar M, Couillin I, Catros V, Boichot E, Lagente V.

Clin Exp Pharmacol Physiol. 2014 Apr;41(4):279-86. doi: 10.1111/1440-1681.12214.


The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.

Sandanger Ø, Ranheim T, Vinge LE, Bliksøen M, Alfsnes K, Finsen AV, Dahl CP, Askevold ET, Florholmen G, Christensen G, Fitzgerald KA, Lien E, Valen G, Espevik T, Aukrust P, Yndestad A.

Cardiovasc Res. 2013 Jul 1;99(1):164-74. doi: 10.1093/cvr/cvt091. Epub 2013 Apr 10.


Inflammasome activation in bovine monocytes by extracellular ATP does not require the purinergic receptor P2X7.

Hussen J, Düvel A, Koy M, Schuberth HJ.

Dev Comp Immunol. 2012 Oct;38(2):312-20. doi: 10.1016/j.dci.2012.06.004. Epub 2012 Jun 19.


Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation.

Qu Y, Misaghi S, Newton K, Gilmour LL, Louie S, Cupp JE, Dubyak GR, Hackos D, Dixit VM.

J Immunol. 2011 Jun 1;186(11):6553-61. doi: 10.4049/jimmunol.1100478. Epub 2011 Apr 20.


IL-1β production is dependent on the activation of purinergic receptors and NLRP3 pathway in human macrophages.

Gicquel T, Robert S, Loyer P, Victoni T, Bodin A, Ribault C, Gleonnec F, Couillin I, Boichot E, Lagente V.

FASEB J. 2015 Oct;29(10):4162-73. doi: 10.1096/fj.14-267393. Epub 2015 Jun 26.


The purinergic 2X7 receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation.

Solini A, Menini S, Rossi C, Ricci C, Santini E, Blasetti Fantauzzi C, Iacobini C, Pugliese G.

J Pathol. 2013 Nov;231(3):342-53. doi: 10.1002/path.4237. Epub 2013 Sep 3.


TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis.

Hoque R, Sohail M, Malik A, Sarwar S, Luo Y, Shah A, Barrat F, Flavell R, Gorelick F, Husain S, Mehal W.

Gastroenterology. 2011 Jul;141(1):358-69. doi: 10.1053/j.gastro.2011.03.041. Epub 2011 Mar 24.


The complex P2X7 receptor/inflammasome in perivascular fat tissue of heavy smokers.

Rossi C, Santini E, Chiarugi M, Salvati A, Comassi M, Vitolo E, Madec S, Solini A.

Eur J Clin Invest. 2014;44(3):295-302. doi: 10.1111/eci.12232. Epub 2014 Jan 20.


Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells.

McGilligan VE, Gregory-Ksander MS, Li D, Moore JE, Hodges RR, Gilmore MS, Moore TC, Dartt DA.

PLoS One. 2013 Sep 10;8(9):e74010. doi: 10.1371/journal.pone.0074010. eCollection 2013 Sep 10.


P2X7R/cryopyrin inflammasome axis inhibition reduces neuroinflammation after SAH.

Chen S, Ma Q, Krafft PR, Hu Q, Rolland W 2nd, Sherchan P, Zhang J, Tang J, Zhang JH.

Neurobiol Dis. 2013 Oct;58:296-307. doi: 10.1016/j.nbd.2013.06.011. Epub 2013 Jun 29.


TLR agonists stimulate Nlrp3-dependent IL-1β production independently of the purinergic P2X7 receptor in dendritic cells and in vivo.

He Y, Franchi L, Núñez G.

J Immunol. 2013 Jan 1;190(1):334-9. doi: 10.4049/jimmunol.1202737. Epub 2012 Dec 7.


Activated human CD4+CD45RO+ memory T-cells indirectly inhibit NLRP3 inflammasome activation through downregulation of P2X7R signalling.

Beynon V, Quintana FJ, Weiner HL.

PLoS One. 2012;7(6):e39576. doi: 10.1371/journal.pone.0039576. Epub 2012 Jun 29.


The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.

Baron L, Gombault A, Fanny M, Villeret B, Savigny F, Guillou N, Panek C, Le Bert M, Lagente V, Rassendren F, Riteau N, Couillin I.

Cell Death Dis. 2015 Feb 5;6:e1629. doi: 10.1038/cddis.2014.576.


Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance.

Carta S, Penco F, Lavieri R, Martini A, Dinarello CA, Gattorno M, Rubartelli A.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2835-40. doi: 10.1073/pnas.1424741112. Epub 2015 Feb 17.


P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-α in cultured mouse microglia.

Shieh CH, Heinrich A, Serchov T, van Calker D, Biber K.

Glia. 2014 Apr;62(4):592-607. doi: 10.1002/glia.22628. Epub 2014 Jan 28.


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