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Items: 1 to 20 of 106

1.

Novel molecular and computational methods improve the accuracy of insertion site analysis in Sleeping Beauty-induced tumors.

Brett BT, Berquam-Vrieze KE, Nannapaneni K, Huang J, Scheetz TE, Dupuy AJ.

PLoS One. 2011;6(9):e24668. doi: 10.1371/journal.pone.0024668.

2.

Identification of Sleeping Beauty transposon insertions in solid tumors using linker-mediated PCR.

Janik CL, Starr TK.

J Vis Exp. 2013 Feb 1;(72):e50156. doi: 10.3791/50156.

3.

Sequencing methods and datasets to improve functional interpretation of sleeping beauty mutagenesis screens.

Riordan JD, Drury LJ, Smith RP, Brett BT, Rogers LM, Scheetz TE, Dupuy AJ.

BMC Genomics. 2014 Dec 19;15:1150. doi: 10.1186/1471-2164-15-1150.

4.

Transposon-based screens for cancer gene discovery in mouse models.

Dupuy AJ.

Semin Cancer Biol. 2010 Aug;20(4):261-8. doi: 10.1016/j.semcancer.2010.05.003. Review.

5.

Sleeping Beauty transposon insertional mutagenesis based mouse models for cancer gene discovery.

Moriarity BS, Largaespada DA.

Curr Opin Genet Dev. 2015 Feb;30:66-72. doi: 10.1016/j.gde.2015.04.007. Review.

6.

Sleeping beauty: a novel cancer gene discovery tool.

Dupuy AJ, Jenkins NA, Copeland NG.

Hum Mol Genet. 2006 Apr 15;15 Spec No 1:R75-9. Review.

7.

Hopping around the tumor genome: transposons for cancer gene discovery.

Collier LS, Largaespada DA.

Cancer Res. 2005 Nov 1;65(21):9607-10. Review.

8.

Retargeting sleeping beauty transposon insertions by engineered zinc finger DNA-binding domains.

Voigt K, Gogol-Döring A, Miskey C, Chen W, Cathomen T, Izsvák Z, Ivics Z.

Mol Ther. 2012 Oct;20(10):1852-62. doi: 10.1038/mt.2012.126.

9.

A DNA transposon-based approach to validate oncogenic mutations in the mouse.

Su Q, Prosser HM, Campos LS, Ortiz M, Nakamura T, Warren M, Dupuy AJ, Jenkins NA, Copeland NG, Bradley A, Liu P.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19904-9. doi: 10.1073/pnas.0807785105.

10.

Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish.

McGrail M, Hatler JM, Kuang X, Liao HK, Nannapaneni K, Watt KE, Uhl JD, Largaespada DA, Vollbrecht E, Scheetz TE, Dupuy AJ, Hostetter JM, Essner JJ.

PLoS One. 2011 Apr 21;6(4):e18826. doi: 10.1371/journal.pone.0018826.

11.

Sleeping Beauty transposon system for genetic etiological research and gene therapy of cancers.

Hou X, Du Y, Deng Y, Wu J, Cao G.

Cancer Biol Ther. 2015;16(1):8-16. doi: 10.4161/15384047.2014.986944. Review.

12.

Harnessing transposons for cancer gene discovery.

Copeland NG, Jenkins NA.

Nat Rev Cancer. 2010 Oct;10(10):696-706. doi: 10.1038/nrc2916. Review.

PMID:
20844553
13.

RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens.

Temiz NA, Moriarity BS, Wolf NK, Riordan JD, Dupuy AJ, Largaespada DA, Sarver AL.

Genome Res. 2016 Jan;26(1):119-29. doi: 10.1101/gr.188649.114.

14.

Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse.

Carlson CM, Frandsen JL, Kirchhof N, McIvor RS, Largaespada DA.

Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17059-64.

15.

Electroporation markedly improves Sleeping Beauty transposon-induced tumorigenesis in mice.

Jung S, Choi HJ, Park HK, Jo W, Jang S, Ryu JE, Kim WJ, Yu ES, Son WC.

Cancer Gene Ther. 2014 Aug;21(8):333-9. doi: 10.1038/cgt.2014.33.

PMID:
24992966
16.

Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma.

Mann KM, Ward JM, Yew CC, Kovochich A, Dawson DW, Black MA, Brett BT, Sheetz TE, Dupuy AJ; Australian Pancreatic Cancer Genome Initiative., Chang DK, Biankin AV, Waddell N, Kassahn KS, Grimmond SM, Rust AG, Adams DJ, Jenkins NA, Copeland NG.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):5934-41. doi: 10.1073/pnas.1202490109.

17.

A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice.

Dupuy AJ, Rogers LM, Kim J, Nannapaneni K, Starr TK, Liu P, Largaespada DA, Scheetz TE, Jenkins NA, Copeland NG.

Cancer Res. 2009 Oct 15;69(20):8150-6. doi: 10.1158/0008-5472.CAN-09-1135.

18.

A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis.

Starr TK, Scott PM, Marsh BM, Zhao L, Than BL, O'Sullivan MG, Sarver AL, Dupuy AJ, Largaespada DA, Cormier RT.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5765-70. doi: 10.1073/pnas.1018012108.

19.

Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies.

Tschida BR, Largaespada DA, Keng VW.

Semin Cell Dev Biol. 2014 Mar;27:86-95. doi: 10.1016/j.semcdb.2014.01.006. Review.

20.

Case-oriented pathways analysis in pancreatic adenocarcinoma using data from a sleeping beauty transposon mutagenesis screen.

Ho YY, Starr TK, LaRue RS, Largaespada DA.

BMC Med Genomics. 2016 Apr 1;9:16. doi: 10.1186/s12920-016-0176-7.

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