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Items: 1 to 20 of 66

1.

E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors.

Shen YF, Chen YH, Chu SY, Lin MI, Hsu HT, Wu PY, Wu CJ, Liu HW, Lin FY, Lin G, Hsu PH, Yang AS, Cheng YS, Wu YT, Wong CH, Tsai MD.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16515-20. doi: 10.1073/pnas.1113107108. Epub 2011 Sep 19.

2.

High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity.

Su CY, Cheng TJ, Lin MI, Wang SY, Huang WI, Lin-Chu SY, Chen YH, Wu CY, Lai MM, Cheng WC, Wu YT, Tsai MD, Cheng YS, Wong CH.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19151-6. doi: 10.1073/pnas.1013592107. Epub 2010 Oct 25.

3.

Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers.

Gerritz SW, Cianci C, Kim S, Pearce BC, Deminie C, Discotto L, McAuliffe B, Minassian BF, Shi S, Zhu S, Zhai W, Pendri A, Li G, Poss MA, Edavettal S, McDonnell PA, Lewis HA, Maskos K, Mörtl M, Kiefersauer R, Steinbacher S, Baldwin ET, Metzler W, Bryson J, Healy MD, Philip T, Zoeckler M, Schartman R, Sinz M, Leyva-Grado VH, Hoffmann HH, Langley DR, Meanwell NA, Krystal M.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15366-71. doi: 10.1073/pnas.1107906108. Epub 2011 Sep 6.

4.

Cyclophilin E functions as a negative regulator to influenza virus replication by impairing the formation of the viral ribonucleoprotein complex.

Wang Z, Liu X, Zhao Z, Xu C, Zhang K, Chen C, Sun L, Gao GF, Ye X, Liu W.

PLoS One. 2011;6(8):e22625. doi: 10.1371/journal.pone.0022625. Epub 2011 Aug 24.

5.

Development of an anti-influenza drug screening assay targeting nucleoproteins with tryptophan fluorescence quenching.

Hung HC, Liu CL, Hsu JT, Horng JT, Fang MY, Wu SY, Ueng SH, Wang MY, Yaw CW, Hou MH.

Anal Chem. 2012 Aug 7;84(15):6391-9. doi: 10.1021/ac2022426. Epub 2012 Jul 10.

PMID:
22712523
6.

Design, synthesis, and in vitro biological evaluation of 1H-1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents targeting virus nucleoprotein.

Cheng H, Wan J, Lin MI, Liu Y, Lu X, Liu J, Xu Y, Chen J, Tu Z, Cheng YS, Ding K.

J Med Chem. 2012 Mar 8;55(5):2144-53. doi: 10.1021/jm2013503. Epub 2012 Feb 27.

PMID:
22332894
7.

Inhibition of influenza A virus replication by influenza B virus nucleoprotein: an insight into interference between influenza A and B viruses.

Wanitchang A, Narkpuk J, Jaru-ampornpan P, Jengarn J, Jongkaewwattana A.

Virology. 2012 Oct 10;432(1):194-203. doi: 10.1016/j.virol.2012.06.016. Epub 2012 Jul 6.

8.

Intracellular oligomerization of influenza virus nucleoprotein.

Prokudina-Kantorovich EN, Semenova NP.

Virology. 1996 Sep 1;223(1):51-6.

9.
10.
11.

Structural basis for RNA binding and homo-oligomer formation by influenza B virus nucleoprotein.

Ng AK, Lam MK, Zhang H, Liu J, Au SW, Chan PK, Wang J, Shaw PC.

J Virol. 2012 Jun;86(12):6758-67. doi: 10.1128/JVI.00073-12. Epub 2012 Apr 11.

12.

Synthesis and inhibitory effects of novel pyrimido-pyrrolo-quinoxalinedione analogues targeting nucleoproteins of influenza A virus H1N1.

Lin MI, Su BH, Lee CH, Wang ST, Wu WC, Dangate P, Wang SY, Huang WI, Cheng TJ, Lin OA, Cheng YS, Tseng YJ, Sun CM.

Eur J Med Chem. 2015 Sep 18;102:477-86. doi: 10.1016/j.ejmech.2015.08.016. Epub 2015 Aug 13.

PMID:
26310893
13.

Functional analysis of the influenza virus H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities.

Chan WH, Ng AK, Robb NC, Lam MK, Chan PK, Au SW, Wang JH, Fodor E, Shaw PC.

J Virol. 2010 Jul;84(14):7337-45. doi: 10.1128/JVI.02474-09. Epub 2010 May 12.

14.

Single-chain intracellular antibodies inhibit influenza virus replication by disrupting interaction of proteins involved in viral replication and transcription.

Mukhtar MM, Li S, Li W, Wan T, Mu Y, Wei W, Kang L, Rasool ST, Xiao Y, Zhu Y, Wu J.

Int J Biochem Cell Biol. 2009 Mar;41(3):554-60. doi: 10.1016/j.biocel.2008.07.001. Epub 2008 Jul 18.

PMID:
18687409
15.

Antisense oligonucleotides targeting the RNA binding region of the NP gene inhibit replication of highly pathogenic avian influenza virus H5N1.

Zhang T, Wang TC, Zhao PS, Liang M, Gao YW, Yang ST, Qin C, Wang CY, Xia XZ.

Int Immunopharmacol. 2011 Dec;11(12):2057-61. doi: 10.1016/j.intimp.2011.08.019. Epub 2011 Sep 18.

PMID:
21933722
16.

Oligomerization paths of the nucleoprotein of influenza A virus.

Tarus B, Bakowiez O, Chenavas S, Duchemin L, Estrozi LF, Bourdieu C, Lejal N, Bernard J, Moudjou M, Chevalier C, Delmas B, Ruigrok RW, Di Primo C, Slama-Schwok A.

Biochimie. 2012 Mar;94(3):776-85. doi: 10.1016/j.biochi.2011.11.009. Epub 2011 Nov 29.

PMID:
22155087
17.

Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome.

Turan K, Mibayashi M, Sugiyama K, Saito S, Numajiri A, Nagata K.

Nucleic Acids Res. 2004 Jan 29;32(2):643-52. Print 2004.

18.

Effect of influenza virus matrix protein and viral RNA on ribonucleoprotein formation and nuclear export.

Huang X, Liu T, Muller J, Levandowski RA, Ye Z.

Virology. 2001 Sep 1;287(2):405-16.

19.

The role of oligomerization for the biological functions of the arenavirus nucleoprotein.

Lennartz F, Hoenen T, Lehmann M, Groseth A, Garten W.

Arch Virol. 2013 Sep;158(9):1895-905. doi: 10.1007/s00705-013-1684-9. Epub 2013 Apr 4.

PMID:
23553456
20.

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