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Items: 1 to 20 of 118

1.

Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor.

Chandrasekaran S, Tan TX, Hall JR, Cook JG.

Mol Cell Biol. 2011 Nov;31(22):4405-16. doi: 10.1128/MCB.06163-11. Epub 2011 Sep 19.

2.

CDK1-dependent inhibition of the E3 ubiquitin ligase CRL4CDT2 ensures robust transition from S Phase to Mitosis.

Rizzardi LF, Coleman KE, Varma D, Matson JP, Oh S, Cook JG.

J Biol Chem. 2015 Jan 2;290(1):556-67. doi: 10.1074/jbc.M114.614701. Epub 2014 Nov 19.

3.

Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.

Sakaguchi H, Takami T, Yasutani Y, Maeda T, Morino M, Ishii T, Shiomi Y, Nishitani H.

PLoS One. 2012;7(9):e46480. doi: 10.1371/journal.pone.0046480. Epub 2012 Sep 28.

4.

Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.

Shibata E, Abbas T, Huang X, Wohlschlegel JA, Dutta A.

Mol Cell Biol. 2011 Aug;31(15):3136-45. doi: 10.1128/MCB.05496-11. Epub 2011 May 31.

5.

Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma.

Benamar M, Guessous F, Du K, Corbett P, Obeid J, Gioeli D, Slingluff CL Jr, Abbas T.

EBioMedicine. 2016 Aug;10:85-100. doi: 10.1016/j.ebiom.2016.06.023. Epub 2016 Jun 16.

6.

Sequential replication-coupled destruction at G1/S ensures genome stability.

Coleman KE, Grant GD, Haggerty RA, Brantley K, Shibata E, Workman BD, Dutta A, Varma D, Purvis JE, Cook JG.

Genes Dev. 2015 Aug 15;29(16):1734-46. doi: 10.1101/gad.263731.115. Epub 2015 Aug 13.

7.

The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing.

Kim Y, Starostina NG, Kipreos ET.

Genes Dev. 2008 Sep 15;22(18):2507-19. doi: 10.1101/gad.1703708.

8.

Expression of the p12 subunit of human DNA polymerase δ (Pol δ), CDK inhibitor p21(WAF1), Cdt1, cyclin A, PCNA and Ki-67 in relation to DNA replication in individual cells.

Zhao H, Zhang S, Xu D, Lee MY, Zhang Z, Lee EY, Darzynkiewicz Z.

Cell Cycle. 2014;13(22):3529-40. doi: 10.4161/15384101.2014.958910.

9.

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation.

Liu E, Li X, Yan F, Zhao Q, Wu X.

J Biol Chem. 2004 Apr 23;279(17):17283-8. Epub 2004 Mar 5.

10.

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

Nishitani H, Sugimoto N, Roukos V, Nakanishi Y, Saijo M, Obuse C, Tsurimoto T, Nakayama KI, Nakayama K, Fujita M, Lygerou Z, Nishimoto T.

EMBO J. 2006 Mar 8;25(5):1126-36. Epub 2006 Feb 16.

11.

A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction.

Raman M, Havens CG, Walter JC, Harper JW.

Mol Cell. 2011 Oct 7;44(1):72-84. doi: 10.1016/j.molcel.2011.06.036.

12.
13.

DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.

Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA.

Genes Dev. 2006 Nov 15;20(22):3117-29. Epub 2006 Nov 3.

14.

14-3-3 proteins play a role in the cell cycle by shielding cdt2 from ubiquitin-mediated degradation.

Dar A, Wu D, Lee N, Shibata E, Dutta A.

Mol Cell Biol. 2014 Nov;34(21):4049-61. doi: 10.1128/MCB.00838-14. Epub 2014 Aug 25.

15.

CRL4(CDT2) targets CHK1 for PCNA-independent destruction.

Huh J, Piwnica-Worms H.

Mol Cell Biol. 2013 Jan;33(2):213-26. doi: 10.1128/MCB.00847-12. Epub 2012 Oct 29.

16.
17.

PCNA-dependent ubiquitination of Cdt1 and p21 in mammalian cells.

Hayashi A, Suenaga N, Shiomi Y, Nishitani H.

Methods Mol Biol. 2014;1170:367-82. doi: 10.1007/978-1-4939-0888-2_19.

PMID:
24906324
18.

Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated Cdt1 proteolysis during S phase and following UV irradiation.

Shiomi Y, Hayashi A, Ishii T, Shinmyozu K, Nakayama J, Sugasawa K, Nishitani H.

Mol Cell Biol. 2012 Jun;32(12):2279-88. doi: 10.1128/MCB.06506-11. Epub 2012 Apr 9.

19.

PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination.

Senga T, Sivaprasad U, Zhu W, Park JH, Arias EE, Walter JC, Dutta A.

J Biol Chem. 2006 Mar 10;281(10):6246-52. Epub 2006 Jan 9.

20.

CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.

Abbas T, Mueller AC, Shibata E, Keaton M, Rossi M, Dutta A.

Mol Cell. 2013 Mar 28;49(6):1147-58. doi: 10.1016/j.molcel.2013.02.003. Epub 2013 Mar 7.

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