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Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas.

Basu-Roy U, Seo E, Ramanathapuram L, Rapp TB, Perry JA, Orkin SH, Mansukhani A, Basilico C.

Oncogene. 2012 May 3;31(18):2270-82. doi: 10.1038/onc.2011.405.


Perspectives on cancer stem cells in osteosarcoma.

Basu-Roy U, Basilico C, Mansukhani A.

Cancer Lett. 2013 Sep 10;338(1):158-67. doi: 10.1016/j.canlet.2012.05.028. Review.


Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage.

Berman SD, Calo E, Landman AS, Danielian PS, Miller ES, West JC, Fonhoue BD, Caron A, Bronson R, Bouxsein ML, Mukherjee S, Lees JA.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11851-6. doi: 10.1073/pnas.0805462105.


Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells.

Basu-Roy U, Bayin NS, Rattanakorn K, Han E, Placantonakis DG, Mansukhani A, Basilico C.

Nat Commun. 2015 Apr 2;6:6411. doi: 10.1038/ncomms7411.


SOX2 plays a critical role in EGFR-mediated self-renewal of human prostate cancer stem-like cells.

Rybak AP, Tang D.

Cell Signal. 2013 Dec;25(12):2734-42. doi: 10.1016/j.cellsig.2013.08.041.


The MET oncogene transforms human primary bone-derived cells into osteosarcomas by targeting committed osteo-progenitors.

Dani N, Olivero M, Mareschi K, van Duist MM, Miretti S, Cuvertino S, Patané S, Calogero R, Ferracini R, Scotlandi K, Fagioli F, Di Renzo MF.

J Bone Miner Res. 2012 Jun;27(6):1322-34. doi: 10.1002/jbmr.1578.


EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer.

Singh S, Trevino J, Bora-Singhal N, Coppola D, Haura E, Altiok S, Chellappan SP.

Mol Cancer. 2012 Sep 25;11:73. doi: 10.1186/1476-4598-11-73.


Profiling of high-grade central osteosarcoma and its putative progenitor cells identifies tumourigenic pathways.

Cleton-Jansen AM, Anninga JK, Briaire-de Bruijn IH, Romeo S, Oosting J, Egeler RM, Gelderblom H, Taminiau AH, Hogendoorn PC.

Br J Cancer. 2009 Dec 1;101(11):1909-18. doi: 10.1038/sj.bjc.6605405. Erratum in: Br J Cancer. 2009 Dec 15;101(12):2064.


The transcription factor Sox2 is required for osteoblast self-renewal.

Basu-Roy U, Ambrosetti D, Favaro R, Nicolis SK, Mansukhani A, Basilico C.

Cell Death Differ. 2010 Aug;17(8):1345-53. doi: 10.1038/cdd.2010.57.


VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2.

Zhao D, Pan C, Sun J, Gilbert C, Drews-Elger K, Azzam DJ, Picon-Ruiz M, Kim M, Ullmer W, El-Ashry D, Creighton CJ, Slingerland JM.

Oncogene. 2015 Jun 11;34(24):3107-19. doi: 10.1038/onc.2014.257.


TSSC3 overexpression reduces stemness and induces apoptosis of osteosarcoma tumor-initiating cells.

Huang Y, Dai H, Guo QN.

Apoptosis. 2012 Aug;17(8):749-61. doi: 10.1007/s10495-012-0734-1.


Distinct functions of Sox2 control self-renewal and differentiation in the osteoblast lineage.

Seo E, Basu-Roy U, Zavadil J, Basilico C, Mansukhani A.

Mol Cell Biol. 2011 Nov;31(22):4593-608. doi: 10.1128/MCB.05798-11.


SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells.

Santini R, Pietrobono S, Pandolfi S, Montagnani V, D'Amico M, Penachioni JY, Vinci MC, Borgognoni L, Stecca B.

Oncogene. 2014 Sep 18;33(38):4697-708. doi: 10.1038/onc.2014.71.


Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model.

Barøy T, Kresse SH, Skårn M, Stabell M, Castro R, Lauvrak S, Llombart-Bosch A, Myklebost O, Meza-Zepeda LA.

Mol Cancer. 2014 Apr 28;13:93. doi: 10.1186/1476-4598-13-93.


FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo.

Brun J, Dieudonné FX, Marty C, Müller J, Schüle R, Patiño-García A, Lecanda F, Fromigué O, Marie PJ.

PLoS One. 2013;8(1):e55034. doi: 10.1371/journal.pone.0055034.


Let-7d miRNA Shows Both Antioncogenic and Oncogenic Functions in Osteosarcoma-Derived 3AB-OS Cancer Stem Cells.

Di Fiore R, Drago-Ferrante R, Pentimalli F, Di Marzo D, Forte IM, Carlisi D, De Blasio A, Tesoriere G, Giordano A, Vento R.

J Cell Physiol. 2016 Aug;231(8):1832-41. doi: 10.1002/jcp.25291.


YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells.

Bora-Singhal N, Nguyen J, Schaal C, Perumal D, Singh S, Coppola D, Chellappan S.

Stem Cells. 2015 Jun;33(6):1705-18. doi: 10.1002/stem.1993.


Transcriptional Profiling Identifies the Signaling Axes of IGF and Transforming Growth Factor-b as Involved in the Pathogenesis of Osteosarcoma.

Yang R, Piperdi S, Zhang Y, Zhu Z, Neophytou N, Hoang BH, Mason G, Geller D, Dorfman H, Meyers PA, Healey JH, Phinney DG, Gorlick R.

Clin Orthop Relat Res. 2016 Jan;474(1):178-89.

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