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FXR activation improves myocardial fatty acid metabolism in a rodent model of obesity-driven cardiotoxicity.

Mencarelli A, Cipriani S, Renga B, D'Amore C, Palladino G, Distrutti E, Baldelli F, Fiorucci S.

Nutr Metab Cardiovasc Dis. 2013 Feb;23(2):94-101. doi: 10.1016/j.numecd.2011.06.008. Epub 2011 Sep 15.


Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.

Pineda Torra I, Claudel T, Duval C, Kosykh V, Fruchart JC, Staels B.

Mol Endocrinol. 2003 Feb;17(2):259-72.


FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats.

Cipriani S, Mencarelli A, Palladino G, Fiorucci S.

J Lipid Res. 2010 Apr;51(4):771-84. doi: 10.1194/jlr.M001602. Epub 2009 Sep 25.


Pomegranate flower improves cardiac lipid metabolism in a diabetic rat model: role of lowering circulating lipids.

Huang TH, Peng G, Kota BP, Li GQ, Yamahara J, Roufogalis BD, Li Y.

Br J Pharmacol. 2005 Jul;145(6):767-74.


Salacia oblonga root improves cardiac lipid metabolism in Zucker diabetic fatty rats: modulation of cardiac PPAR-alpha-mediated transcription of fatty acid metabolic genes.

Huang TH, Yang Q, Harada M, Uberai J, Radford J, Li GQ, Yamahara J, Roufogalis BD, Li Y.

Toxicol Appl Pharmacol. 2006 Jan 1;210(1-2):78-85. Epub 2005 Aug 29.


Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase.

Miyata M, Matsuda Y, Tsuchiya H, Kitada H, Akase T, Shimada M, Nagata K, Gonzalez FJ, Yamazoe Y.

Drug Metab Pharmacokinet. 2006 Aug;21(4):315-23.


Differential activation of the human farnesoid X receptor depends on the pattern of expressed isoforms and the bile acid pool composition.

Vaquero J, Monte MJ, Dominguez M, Muntané J, Marin JJ.

Biochem Pharmacol. 2013 Oct 1;86(7):926-39. doi: 10.1016/j.bcp.2013.07.022. Epub 2013 Aug 6.


The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice.

Mencarelli A, Cipriani S, Renga B, Francisci D, Palladino G, Distrutti E, Baldelli F, Fiorucci S.

PLoS One. 2010 Oct 8;5(10):e13238. doi: 10.1371/journal.pone.0013238.


Antiatherosclerotic effect of farnesoid X receptor.

Mencarelli A, Renga B, Distrutti E, Fiorucci S.

Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H272-81. doi: 10.1152/ajpheart.01075.2008. Epub 2008 Nov 21.


Pharmacological activation of the bile acid nuclear farnesoid X receptor is feasible in patients with quiescent Crohn's colitis.

van Schaik FD, Gadaleta RM, Schaap FG, van Mil SW, Siersema PD, Oldenburg B, van Erpecum KJ.

PLoS One. 2012;7(11):e49706. doi: 10.1371/journal.pone.0049706. Epub 2012 Nov 26.


AZ 242, a novel PPARalpha/gamma agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats.

Ljung B, Bamberg K, Dahllöf B, Kjellstedt A, Oakes ND, Ostling J, Svensson L, Camejo G.

J Lipid Res. 2002 Nov;43(11):1855-63.


Beneficial effect of farnesoid X receptor activation on metabolism in a diabetic rat model.

Zhang HM, Wang X, Wu ZH, Liu HL, Chen W, Zhang ZZ, Chen D, Zeng TS.

Mol Med Rep. 2016 Mar;13(3):2135-42. doi: 10.3892/mmr.2016.4761. Epub 2016 Jan 12.


The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis.

Mencarelli A, Renga B, Migliorati M, Cipriani S, Distrutti E, Santucci L, Fiorucci S.

J Immunol. 2009 Nov 15;183(10):6657-66. doi: 10.4049/jimmunol.0901347. Epub 2009 Oct 30.


Farnesoid X receptor regulates bile acid-amino acid conjugation.

Pircher PC, Kitto JL, Petrowski ML, Tangirala RK, Bischoff ED, Schulman IG, Westin SK.

J Biol Chem. 2003 Jul 25;278(30):27703-11. Epub 2003 May 16.


Effect of BM 17.0744, a PPARalpha ligand, on the metabolism of perfused hearts from control and diabetic mice.

Aasum E, Cooper M, Severson DL, Larsen TS.

Can J Physiol Pharmacol. 2005 Feb;83(2):183-90.


Knockdown of ATP8B1 expression leads to specific downregulation of the bile acid sensor FXR in HepG2 cells: effect of the FXR agonist GW4064.

Martínez-Fernández P, Hierro L, Jara P, Alvarez L.

Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1119-29. doi: 10.1152/ajpgi.90371.2008. Epub 2009 Feb 19.


Regulation of carbohydrate metabolism by the farnesoid X receptor.

Stayrook KR, Bramlett KS, Savkur RS, Ficorilli J, Cook T, Christe ME, Michael LF, Burris TP.

Endocrinology. 2005 Mar;146(3):984-91. Epub 2004 Nov 24.


The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis.

Fiorucci S, Antonelli E, Rizzo G, Renga B, Mencarelli A, Riccardi L, Orlandi S, Pellicciari R, Morelli A.

Gastroenterology. 2004 Nov;127(5):1497-512.


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