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C5aR-antagonist significantly reduces the deleterious effect of a blunt chest trauma on fracture healing.

Recknagel S, Bindl R, Kurz J, Wehner T, Schoengraf P, Ehrnthaller C, Qu H, Gebhard F, Huber-Lang M, Lambris JD, Claes L, Ignatius A.

J Orthop Res. 2012 Apr;30(4):581-6. doi: 10.1002/jor.21561. Epub 2011 Sep 15.


Conversion from external fixator to intramedullary nail causes a second hit and impairs fracture healing in a severe trauma model.

Recknagel S, Bindl R, Wehner T, Göckelmann M, Wehrle E, Gebhard F, Huber-Lang M, Claes L, Ignatius A.

J Orthop Res. 2013 Mar;31(3):465-71. doi: 10.1002/jor.22242. Epub 2012 Oct 15.


C5aR inhibition in the early inflammatory phase does not affect bone regeneration in a model of uneventful fracture healing.

Ehrnthaller C, Huber-Lang M, Kovtun A, Rapp AE, Kemmler J, Gebhard F, Ignatius A.

Eur J Med Res. 2016 Oct 26;21(1):42.


Experimental blunt chest trauma impairs fracture healing in rats.

Recknagel S, Bindl R, Kurz J, Wehner T, Ehrnthaller C, Knöferl MW, Gebhard F, Huber-Lang M, Claes L, Ignatius A.

J Orthop Res. 2011 May;29(5):734-9. doi: 10.1002/jor.21299. Epub 2010 Dec 23.


Systemic inflammation induced by a thoracic trauma alters the cellular composition of the early fracture callus.

Recknagel S, Bindl R, Brochhausen C, Göckelmann M, Wehner T, Schoengraf P, Huber-Lang M, Claes L, Ignatius A.

J Trauma Acute Care Surg. 2013 Feb;74(2):531-7. doi: 10.1097/TA.0b013e318278956d.


The role of C5a in the innate immune response after experimental blunt chest trauma.

Flierl MA, Perl M, Rittirsch D, Bartl C, Schreiber H, Fleig V, Schlaf G, Liener U, Brueckner UB, Gebhard F, Huber-Lang MS.

Shock. 2008 Jan;29(1):25-31.


Cytokine productive capacity of alveolar macrophages and Kupffer cells after femoral fracture and blunt chest trauma in a murine trauma model.

Neunaber C, Oestern S, Andruszkow H, Zeckey C, Mommsen P, Kutter D, Stöfen M, Krettek C, Hildebrand F.

Immunol Lett. 2013 May;152(2):159-66. doi: 10.1016/j.imlet.2013.05.012. Epub 2013 Jun 2.


Exposure to 100% Oxygen Abolishes the Impairment of Fracture Healing after Thoracic Trauma.

Kemmler J, Bindl R, McCook O, Wagner F, Gröger M, Wagner K, Scheuerle A, Radermacher P, Ignatius A.

PLoS One. 2015 Jul 6;10(7):e0131194. doi: 10.1371/journal.pone.0131194. eCollection 2015.


Complement C3 and C5 deficiency affects fracture healing.

Ehrnthaller C, Huber-Lang M, Nilsson P, Bindl R, Redeker S, Recknagel S, Rapp A, Mollnes T, Amling M, Gebhard F, Ignatius A.

PLoS One. 2013 Nov 18;8(11):e81341. doi: 10.1371/journal.pone.0081341. eCollection 2013.


Transdermal pharmacology of small molecule cyclic C5a antagonists.

Proctor LM, Woodruff TM, Sharma P, Shiels IA, Taylor SM.

Adv Exp Med Biol. 2006;586:329-45.


Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing.

Bergdolt S, Kovtun A, Hägele Y, Liedert A, Schinke T, Amling M, Huber-Lang M, Ignatius A.

PLoS One. 2017 Jun 14;12(6):e0179512. doi: 10.1371/journal.pone.0179512. eCollection 2017.


Effects of nail rigidity on fracture healing. Strength and mineralisation in rat femoral bone.

Utvåg SE, Reikerås O.

Arch Orthop Trauma Surg. 1998;118(1-2):7-13.


The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury.

Brennan FH, Gordon R, Lao HW, Biggins PJ, Taylor SM, Franklin RJ, Woodruff TM, Ruitenberg MJ.

J Neurosci. 2015 Apr 22;35(16):6517-31. doi: 10.1523/JNEUROSCI.5218-14.2015.


The anaphylatoxin receptor C5aR is present during fracture healing in rats and mediates osteoblast migration in vitro.

Ignatius A, Ehrnthaller C, Brenner RE, Kreja L, Schoengraf P, Lisson P, Blakytny R, Recknagel S, Claes L, Gebhard F, Lambris JD, Huber-Lang M.

J Trauma. 2011 Oct;71(4):952-60. doi: 10.1097/TA.0b013e3181f8aa2d.


Short-term muscle atrophy caused by botulinum toxin-A local injection impairs fracture healing in the rat femur.

Hao Y, Ma Y, Wang X, Jin F, Ge S.

J Orthop Res. 2012 Apr;30(4):574-80. doi: 10.1002/jor.21553. Epub 2011 Sep 14.


Human parathyroid hormone (1-34) accelerates natural fracture healing process in the femoral osteotomy model of cynomolgus monkeys.

Manabe T, Mori S, Mashiba T, Kaji Y, Iwata K, Komatsubara S, Seki A, Sun YX, Yamamoto T.

Bone. 2007 Jun;40(6):1475-82. Epub 2007 Feb 2.


Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats.

Arumugam TV, Woodruff TM, Stocks SZ, Proctor LM, Pollitt S, Shiels IA, Reid RC, Fairlie DP, Taylor SM.

J Hepatol. 2004 Jun;40(6):934-41.


Low dose of propranolol does not affect rat osteotomy healing and callus strength.

Smitham P, Crossfield L, Hughes G, Goodship A, Blunn G, Chenu C.

J Orthop Res. 2014 Jul;32(7):887-93. doi: 10.1002/jor.22619. Epub 2014 Apr 7.


Sclerostin monoclonal antibody enhanced bone fracture healing in an open osteotomy model in rats.

Suen PK, He YX, Chow DH, Huang L, Li C, Ke HZ, Ominsky MS, Qin L.

J Orthop Res. 2014 Aug;32(8):997-1005. doi: 10.1002/jor.22636. Epub 2014 Apr 30.


Effect of COX-2-specific inhibition on fracture-healing in the rat femur.

Brown KM, Saunders MM, Kirsch T, Donahue HJ, Reid JS.

J Bone Joint Surg Am. 2004 Jan;86-A(1):116-23.


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