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Items: 1 to 20 of 72

1.

Detrimental effects of arachidonic acid and its metabolites in cellular and mouse models of Alzheimer's disease: structural insight.

Amtul Z, Uhrig M, Wang L, Rozmahel RF, Beyreuther K.

Neurobiol Aging. 2012 Apr;33(4):831.e21-31. doi: 10.1016/j.neurobiolaging.2011.07.014. Epub 2011 Sep 13.

PMID:
21920632
2.

Structural insight into the differential effects of omega-3 and omega-6 fatty acids on the production of Abeta peptides and amyloid plaques.

Amtul Z, Uhrig M, Rozmahel RF, Beyreuther K.

J Biol Chem. 2011 Feb 25;286(8):6100-7. doi: 10.1074/jbc.M110.183608. Epub 2010 Oct 22.

3.

Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice.

Hoshino T, Murao N, Namba T, Takehara M, Adachi H, Katsuno M, Sobue G, Matsushima T, Suzuki T, Mizushima T.

J Neurosci. 2011 Apr 6;31(14):5225-34. doi: 10.1523/JNEUROSCI.5478-10.2011.

4.

Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation.

Kummer MP, Hermes M, Delekarte A, Hammerschmidt T, Kumar S, Terwel D, Walter J, Pape HC, König S, Roeber S, Jessen F, Klockgether T, Korte M, Heneka MT.

Neuron. 2011 Sep 8;71(5):833-44. doi: 10.1016/j.neuron.2011.07.001.

5.

Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor.

Barten DM, Guss VL, Corsa JA, Loo A, Hansel SB, Zheng M, Munoz B, Srinivasan K, Wang B, Robertson BJ, Polson CT, Wang J, Roberts SB, Hendrick JP, Anderson JJ, Loy JK, Denton R, Verdoorn TA, Smith DW, Felsenstein KM.

J Pharmacol Exp Ther. 2005 Feb;312(2):635-43. Epub 2004 Sep 27.

6.

Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons.

Yang GZ, Yang M, Lim Y, Lu JJ, Wang TH, Qi JG, Zhong JH, Zhou XF.

J Neurochem. 2012 Sep;122(5):1010-22. doi: 10.1111/j.1471-4159.2012.07845.x.

7.

Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease.

Amtul Z, Wang L, Westaway D, Rozmahel RF.

Neuroscience. 2010 Aug 25;169(2):781-6. doi: 10.1016/j.neuroscience.2010.05.031. Epub 2010 May 21.

PMID:
20493928
8.

No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease.

Hillmann A, Hahn S, Schilling S, Hoffmann T, Demuth HU, Bulic B, Schneider-Axmann T, Bayer TA, Weggen S, Wirths O.

Neurobiol Aging. 2012 Apr;33(4):833.e39-50. doi: 10.1016/j.neurobiolaging.2011.08.006. Epub 2011 Sep 22.

PMID:
21943956
9.

Phospholipids and a phospholipid-rich diet alter the in vitro amyloid-beta peptide levels and amyloid-beta 42/40 ratios.

Amtul Z, Uhrig M, Supino R, Beyreuther K.

Neurosci Lett. 2010 Sep 6;481(2):73-7. doi: 10.1016/j.neulet.2010.06.046. Epub 2010 Jun 19.

PMID:
20600609
10.

[Alzheimer disease: cellular and molecular aspects].

Octave JN.

Bull Mem Acad R Med Belg. 2005;160(10-12):445-9; discussion 450-1. French.

PMID:
16768248
11.

Additive effects of fatty acid mixtures on the levels and ratio of amyloid β40/42 peptides differ from the effects of individual fatty acids.

Amtul Z, Uhrig M, Beyreuther K.

J Neurosci Res. 2011 Nov;89(11):1795-801. doi: 10.1002/jnr.22706. Epub 2011 Jul 11.

PMID:
21748777
12.

A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease.

Jeon S, Bose S, Hur J, Jun K, Kim YK, Cho KS, Koo BS.

J Ethnopharmacol. 2011 Sep 1;137(1):783-9. doi: 10.1016/j.jep.2011.06.046. Epub 2011 Jul 5.

PMID:
21762767
13.

1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.

Imbimbo BP, Del Giudice E, Colavito D, D'Arrigo A, Dalle Carbonare M, Villetti G, Facchinetti F, Volta R, Pietrini V, Baroc MF, Serneels L, De Strooper B, Leon A.

J Pharmacol Exp Ther. 2007 Dec;323(3):822-30. Epub 2007 Sep 25.

14.

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.

Biochemistry. 1998 Nov 24;37(47):16465-71.

PMID:
9843412
15.
16.

Amyloid-beta levels are significantly reduced and spatial memory defects are rescued in a novel neuroserpin-deficient Alzheimer's disease transgenic mouse model.

Fabbro S, Schaller K, Seeds NW.

J Neurochem. 2011 Sep;118(5):928-38. doi: 10.1111/j.1471-4159.2011.07359.x. Epub 2011 Jul 18.

17.

A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model.

Lim GP, Calon F, Morihara T, Yang F, Teter B, Ubeda O, Salem N Jr, Frautschy SA, Cole GM.

J Neurosci. 2005 Mar 23;25(12):3032-40.

18.

Amyloid neuropathology in the single Arctic APP transgenic model affects interconnected brain regions.

Rönnbäck A, Sagelius H, Bergstedt KD, Näslund J, Westermark GT, Winblad B, Graff C.

Neurobiol Aging. 2012 Apr;33(4):831.e11-9. doi: 10.1016/j.neurobiolaging.2011.07.012. Epub 2011 Aug 31.

PMID:
21880397
19.

Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.

Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A.

J Biol Chem. 2008 Jun 13;283(24):16488-96. doi: 10.1074/jbc.M801279200. Epub 2008 Apr 21.

20.

alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.

Jäger S, Leuchtenberger S, Martin A, Czirr E, Wesselowski J, Dieckmann M, Waldron E, Korth C, Koo EH, Heneka M, Weggen S, Pietrzik CU.

J Neurochem. 2009 Dec;111(6):1369-82. doi: 10.1111/j.1471-4159.2009.06420.x.

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