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Items: 1 to 20 of 147

1.

Synthesis of diastereomerically pure nucleotide phosphoramidates.

Ross BS, Reddy PG, Zhang HR, Rachakonda S, Sofia MJ.

J Org Chem. 2011 Oct 21;76(20):8311-9. doi: 10.1021/jo201492m. Epub 2011 Sep 26.

PMID:
21916475
2.

The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.

McGuigan C, Perrone P, Madela K, Neyts J.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4316-20. doi: 10.1016/j.bmcl.2009.05.122. Epub 2009 Jun 10.

PMID:
19523820
3.

Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.

Sofia MJ, Bao D, Chang W, Du J, Nagarathnam D, Rachakonda S, Reddy PG, Ross BS, Wang P, Zhang HR, Bansal S, Espiritu C, Keilman M, Lam AM, Steuer HM, Niu C, Otto MJ, Furman PA.

J Med Chem. 2010 Oct 14;53(19):7202-18. doi: 10.1021/jm100863x.

PMID:
20845908
4.

Synthesis of stable isotope labeled analogs of the anti-hepatitis C virus nucleotide prodrugs PSI-7977 and PSI-352938.

Chun BK, Du J, Zhang HR, Chang W, Ross BS, Jiang Y, Bao D, Espiritu CL, Keilman M, Steuer HM, Furman PA, Sofia MJ.

Nucleosides Nucleotides Nucleic Acids. 2011 Nov;30(11):886-96. doi: 10.1080/15257770.2011.614308.

PMID:
22060553
5.

Aryloxy phosphoramidate triesters as pro-tides.

Cahard D, McGuigan C, Balzarini J.

Mini Rev Med Chem. 2004 May;4(4):371-81. Review.

PMID:
15134540
6.

Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus.

McGuigan C, Madela K, Aljarah M, Gilles A, Battina SK, Ramamurty CV, Srinivas Rao C, Vernachio J, Hutchins J, Hall A, Kolykhalov A, Henson G, Chamberlain S.

Bioorg Med Chem Lett. 2011 Oct 1;21(19):6007-12. doi: 10.1016/j.bmcl.2011.06.013. Epub 2011 Aug 17.

PMID:
21856153
7.

Model synthesis of nucleoside boranophosphoramidate with amino acid for prodrug purpose.

Li P, Shaw BR.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):675-8.

PMID:
16248012
8.

Phosphoramidate prodrugs deliver with potency against hepatitis C virus.

Mehellou Y.

ChemMedChem. 2010 Nov 8;5(11):1841-2. doi: 10.1002/cmdc.201000310. No abstract available.

PMID:
20865770
9.

Rapid differentiation of nucleotide phosphoramidate diastereomers by electrospray ionization tandem mass spectrometry.

Bao D, Reddy PG, Ross BS, Sofia MJ.

Rapid Commun Mass Spectrom. 2012 Aug 30;26(16):1887-92. doi: 10.1002/rcm.6307.

PMID:
22777791
10.

Synthesis and anti-herpetic activity of phosphoramidate ProTides.

Maiti M, Persoons L, Andrei G, Snoeck R, Balzarini J, Herdewijn P.

ChemMedChem. 2013 Jun;8(6):985-93. doi: 10.1002/cmdc.201300035. Epub 2013 Apr 18.

PMID:
23606629
11.

Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.

Kirschberg TA, Mish MR, Zhang L, Squires NH, Wang KY, Cho A, Feng JY, Fenaux M, Babusis D, Park Y, Ray AS, Kim CU.

Bioorg Med Chem Lett. 2015 Mar 1;25(5):1040-3. doi: 10.1016/j.bmcl.2015.01.021. Epub 2015 Jan 17.

PMID:
25650256
12.

A novel synthesis of antiviral nucleoside phosphoramidate and thiophosphoramidate prodrugs via nucleoside H-phosphonamidates.

Sun Q, Li X, Gong S, Liu G, Shen L, Peng L.

Nucleosides Nucleotides Nucleic Acids. 2013;32(11):617-38. doi: 10.1080/15257770.2013.838262.

PMID:
24138500
13.

Influence of the nucleobase and anchimeric assistance of the carboxyl acid groups in the hydrolysis of amino acid nucleoside phosphoramidates.

Maiti M, Michielssens S, Dyubankova N, Maiti M, Lescrinier E, Ceulemans A, Herdewijn P.

Chemistry. 2012 Jan 16;18(3):857-68. doi: 10.1002/chem.201102279. Epub 2011 Dec 15.

PMID:
22173724
14.

Parallel solid-phase synthesis of nucleoside phosphoramidate libraries.

Jin Y, Chen X, Côté M, Roland A, Korba B, Mounir S, Iyer RP.

Bioorg Med Chem Lett. 2001 Aug 20;11(16):2057-60.

PMID:
11514138
15.

Synthesis of phosphoramidate prodrugs: ProTide approach.

Serpi M, Madela K, Pertusati F, Slusarczyk M.

Curr Protoc Nucleic Acid Chem. 2013 Jun;Chapter 15:Unit15.5. doi: 10.1002/0471142700.nc1505s53.

PMID:
23775807
16.

Activation mechanisms of nucleoside phosphoramidate prodrugs.

Freel Meyers CL, Borch RF.

J Med Chem. 2000 Nov 2;43(22):4319-27.

PMID:
11063626
17.

Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.

McGuigan C, Gilles A, Madela K, Aljarah M, Holl S, Jones S, Vernachio J, Hutchins J, Ames B, Bryant KD, Gorovits E, Ganguly B, Hunley D, Hall A, Kolykhalov A, Liu Y, Muhammad J, Raja N, Walters R, Wang J, Chamberlain S, Henson G.

J Med Chem. 2010 Jul 8;53(13):4949-57. doi: 10.1021/jm1003792.

PMID:
20527890
18.

Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs.

Rondla R, Coats SJ, McBrayer TR, Grier J, Johns M, Tharnish PM, Whitaker T, Zhou L, Schinazi RF.

Antivir Chem Chemother. 2009 Oct 19;20(2):99-106. doi: 10.3851/IMP1400.

PMID:
19843980
19.

Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs.

Cho JH, Bondana L, Detorio MA, Montero C, Bassit LC, Amblard F, Coats SJ, Schinazi RF.

Bioorg Med Chem. 2014 Dec 1;22(23):6665-71. doi: 10.1016/j.bmc.2014.10.003. Epub 2014 Oct 13.

20.

Aspartic acid based nucleoside phosphoramidate prodrugs as potent inhibitors of hepatitis C virus replication.

Maiti M, Maiti M, Rozenski J, De Jonghe S, Herdewijn P.

Org Biomol Chem. 2015 May 14;13(18):5158-74. doi: 10.1039/c5ob00427f.

PMID:
25849139

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