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Profiling of sputum inflammatory mediators in asthma and chronic obstructive pulmonary disease.

Bafadhel M, McCormick M, Saha S, McKenna S, Shelley M, Hargadon B, Mistry V, Reid C, Parker D, Dodson P, Jenkins M, Lloyd A, Rugman P, Newbold P, Brightling CE.

Respiration. 2012;83(1):36-44. doi: 10.1159/000330667. Epub 2011 Sep 7.


Sputum IL-5 concentration is associated with a sputum eosinophilia and attenuated by corticosteroid therapy in COPD.

Bafadhel M, Saha S, Siva R, McCormick M, Monteiro W, Rugman P, Dodson P, Pavord ID, Newbold P, Brightling CE.

Respiration. 2009;78(3):256-62. doi: 10.1159/000221902. Epub 2009 May 27.


A comparison of serum and sputum inflammatory mediator profiles in patients with asthma and COPD.

Cao Y, Gong W, Zhang H, Liu B, Li B, Wu X, Duan X, Dong J.

J Int Med Res. 2012;40(6):2231-42.


Airway inflammation and cellular stress in noneosinophilic atopic asthma.

Tsoumakidou M, Papadopouli E, Tzanakis N, Siafakas NM.

Chest. 2006 May;129(5):1194-202.


Sputum ADAM8 expression is increased in severe asthma and COPD.

Oreo KM, Gibson PG, Simpson JL, Wood LG, McDonald VM, Baines KJ.

Clin Exp Allergy. 2014 Mar;44(3):342-52. doi: 10.1111/cea.12223.


Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers.

Bafadhel M, McKenna S, Terry S, Mistry V, Reid C, Haldar P, McCormick M, Haldar K, Kebadze T, Duvoix A, Lindblad K, Patel H, Rugman P, Dodson P, Jenkins M, Saunders M, Newbold P, Green RH, Venge P, Lomas DA, Barer MR, Johnston SL, Pavord ID, Brightling CE.

Am J Respir Crit Care Med. 2011 Sep 15;184(6):662-71. doi: 10.1164/rccm.201104-0597OC.


Biological clustering supports both "Dutch" and "British" hypotheses of asthma and chronic obstructive pulmonary disease.

Ghebre MA, Bafadhel M, Desai D, Cohen SE, Newbold P, Rapley L, Woods J, Rugman P, Pavord ID, Newby C, Burton PR, May RD, Brightling CE.

J Allergy Clin Immunol. 2015 Jan;135(1):63-72. doi: 10.1016/j.jaci.2014.06.035. Epub 2014 Aug 13.


Airway IL-1β and Systemic Inflammation as Predictors of Future Exacerbation Risk in Asthma and COPD.

Fu JJ, McDonald VM, Baines KJ, Gibson PG.

Chest. 2015 Sep;148(3):618-29. doi: 10.1378/chest.14-2337.


Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD.

Doe C, Bafadhel M, Siddiqui S, Desai D, Mistry V, Rugman P, McCormick M, Woods J, May R, Sleeman MA, Anderson IK, Brightling CE.

Chest. 2010 Nov;138(5):1140-7. doi: 10.1378/chest.09-3058. Epub 2010 Jun 10.


Local and systemic cellular inflammation and cytokine release in chronic obstructive pulmonary disease.

Moermans C, Heinen V, Nguyen M, Henket M, Sele J, Manise M, Corhay JL, Louis R.

Cytokine. 2011 Nov;56(2):298-304. doi: 10.1016/j.cyto.2011.07.010. Epub 2011 Aug 30.


Comparison of cellular and biochemical markers of airway inflammation in patients with mild-to-moderate asthma and chronic obstructive pulmonary disease: an induced sputum and bronchoalveolar lavage fluid study.

Gorska K, Krenke R, Domagala-Kulawik J, Korczynski P, Nejman-Gryz P, Kosciuch J, Hildebrand K, Chazan R.

J Physiol Pharmacol. 2008 Dec;59 Suppl 6:271-83.


High mobility group protein B1 (HMGB1) in Asthma: comparison of patients with chronic obstructive pulmonary disease and healthy controls.

Hou C, Zhao H, Liu L, Li W, Zhou X, Lv Y, Shen X, Liang Z, Cai S, Zou F.

Mol Med. 2011;17(7-8):807-15. doi: 10.2119/molmed.2010.00173. Epub 2011 Mar 3.


Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine.

Barczyk A, Pierzchala W, Sozañska E.

Respir Med. 2003 Jun;97(6):726-33.


Optimized dialysis and protease inhibition of sputum dithiothreitol supernatants.

Erin EM, Jenkins GR, Kon OM, Zacharasiewicz AS, Nicholson GC, Neighbour H, Tennant RC, Tan AJ, Leaker BR, Bush A, Jose PJ, Barnes PJ, Hansel TT.

Am J Respir Crit Care Med. 2008 Jan 15;177(2):132-41. Epub 2007 Oct 25. Retraction in: Am J Respir Crit Care Med. 2011 Feb 1;183(3):418.


Biological markers in induced sputum of patients with different phenotypes of chronic airway obstruction.

Bartoli ML, Di Franco A, Vagaggini B, Bacci E, Cianchetti S, Dente FL, Tonelli M, Paggiaro PL.

Respiration. 2009;77(3):265-72. doi: 10.1159/000176385. Epub 2008 Dec 11.


Granulocyte-macrophage colony-stimulating factor expression in induced sputum and bronchial mucosa in asthma and COPD.

Saha S, Doe C, Mistry V, Siddiqui S, Parker D, Sleeman M, Cohen ES, Brightling CE.

Thorax. 2009 Aug;64(8):671-6. doi: 10.1136/thx.2008.108290. Epub 2009 Feb 12.


Multi-analyte profiling of inflammatory mediators in COPD sputum--the effects of processing.

Pedersen F, Holz O, Lauer G, Quintini G, Kiwull-Schöne H, Kirsten AM, Magnussen H, Rabe KF, Goldmann T, Watz H.

Cytokine. 2015 Feb;71(2):401-4. doi: 10.1016/j.cyto.2014.10.008. Epub 2014 Nov 15.


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