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Items: 1 to 20 of 95

1.

Identification of novel functional inhibitors of acid sphingomyelinase.

Kornhuber J, Muehlbacher M, Trapp S, Pechmann S, Friedl A, Reichel M, Mühle C, Terfloth L, Groemer TW, Spitzer GM, Liedl KR, Gulbins E, Tripal P.

PLoS One. 2011;6(8):e23852. doi: 10.1371/journal.pone.0023852. Epub 2011 Aug 31.

2.

Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications.

Kornhuber J, Tripal P, Reichel M, Mühle C, Rhein C, Muehlbacher M, Groemer TW, Gulbins E.

Cell Physiol Biochem. 2010;26(1):9-20. doi: 10.1159/000315101. Epub 2010 May 18. Review.

3.

Functional inhibitors of acid sphingomyelinase (FIASMAs).

Kornhuber J, Tripal P, Gulbins E, Muehlbacher M.

Handb Exp Pharmacol. 2013;(215):169-86. doi: 10.1007/978-3-7091-1368-4_9. Review.

PMID:
23579455
4.

Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.

Kornhuber J, Tripal P, Reichel M, Terfloth L, Bleich S, Wiltfang J, Gulbins E.

J Med Chem. 2008 Jan 24;51(2):219-37. Epub 2007 Nov 21.

PMID:
18027916
5.

Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis.

Becker KA, Riethmüller J, Lüth A, Döring G, Kleuser B, Gulbins E.

Am J Respir Cell Mol Biol. 2010 Jun;42(6):716-24. doi: 10.1165/rcmb.2009-0174OC. Epub 2009 Jul 27.

PMID:
19635928
6.

Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase.

Petersen NH, Olsen OD, Groth-Pedersen L, Ellegaard AM, Bilgin M, Redmer S, Ostenfeld MS, Ulanet D, Dovmark TH, Lønborg A, Vindeløv SD, Hanahan D, Arenz C, Ejsing CS, Kirkegaard T, Rohde M, Nylandsted J, Jäättelä M.

Cancer Cell. 2013 Sep 9;24(3):379-93. doi: 10.1016/j.ccr.2013.08.003.

7.

Potent inhibition of acid sphingomyelinase by phosphoinositide analogues.

Roth AG, Redmer S, Arenz C.

Chembiochem. 2009 Sep 21;10(14):2367-74. doi: 10.1002/cbic.200900281.

PMID:
19688786
8.

Role of acid sphingomyelinase in the regulation of mast cell function.

Yang W, Schmid E, Nurbaeva MK, Szteyn K, Leibrock C, Yan J, Schaller M, Gulbins E, Shumilina E, Lang F.

Clin Exp Allergy. 2014 Jan;44(1):79-90. doi: 10.1111/cea.12229.

PMID:
24164338
9.

Alternative splicing of SMPD1 coding for acid sphingomyelinase in major depression.

Rhein C, Reichel M, Kramer M, Rotter A, Lenz B, Mühle C, Gulbins E, Kornhuber J.

J Affect Disord. 2017 Feb;209:10-15. doi: 10.1016/j.jad.2016.09.019. Epub 2016 Sep 28.

PMID:
27866044
10.

Acid sphingomyelinase regulates platelet cell membrane scrambling, secretion, and thrombus formation.

Münzer P, Borst O, Walker B, Schmid E, Feijge MA, Cosemans JM, Chatterjee M, Schmidt EM, Schmidt S, Towhid ST, Leibrock C, Elvers M, Schaller M, Seizer P, Ferlinz K, May AE, Gulbins E, Heemskerk JW, Gawaz M, Lang F.

Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):61-71. doi: 10.1161/ATVBAHA.112.300210. Epub 2013 Nov 14.

11.

Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis.

Peng H, Li C, Kadow S, Henry BD, Steinmann J, Becker KA, Riehle A, Beckmann N, Wilker B, Li PL, Pritts T, Edwards MJ, Zhang Y, Gulbins E, Grassmé H.

J Mol Med (Berl). 2015 Jun;93(6):675-89. doi: 10.1007/s00109-014-1246-y. Epub 2015 Jan 25.

12.

Acid sphingomyelinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice.

Dhami R, He X, Schuchman EH.

Cell Physiol Biochem. 2010;26(4-5):749-60. doi: 10.1159/000322342. Epub 2010 Oct 29.

13.

Sphingomyelin analogues as inhibitors of sphingomyelinase.

Taguchi M, Sugimoto K, Goda K, Akama T, Yamamoto K, Suzuki T, Tomishima Y, Nishiguchi M, Arai K, Takahashi K, Kobori T.

Bioorg Med Chem Lett. 2003 Jun 16;13(12):1963-6.

PMID:
12781174
14.

Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses.

Bai A, Kokkotou E, Zheng Y, Robson SC.

Cell Death Dis. 2015 Jul 23;6:e1828. doi: 10.1038/cddis.2015.178.

15.

Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease.

Lee JK, Jin HK, Park MH, Kim BR, Lee PH, Nakauchi H, Carter JE, He X, Schuchman EH, Bae JS.

J Exp Med. 2014 Jul 28;211(8):1551-70. doi: 10.1084/jem.20132451. Epub 2014 Jul 21.

16.

c-Abl is an upstream regulator of acid sphingomyelinase in apoptosis induced by inhibition of integrins αvβ3 and αvβ5.

Ren X, Xu J, Cooper JP, Kang MH, Erdreich-Epstein A.

PLoS One. 2012;7(8):e42291. doi: 10.1371/journal.pone.0042291. Epub 2012 Aug 3.

17.

Increased acid sphingomyelinase activity in peripheral blood cells of acutely intoxicated patients with alcohol dependence.

Reichel M, Greiner E, Richter-Schmidinger T, Yedibela O, Tripal P, Jacobi A, Bleich S, Gulbins E, Kornhuber J.

Alcohol Clin Exp Res. 2010 Jan;34(1):46-50. doi: 10.1111/j.1530-0277.2009.01064.x. Epub 2009 Oct 23.

PMID:
19860808
18.

Differential activation of acid sphingomyelinase and ceramide release determines invasiveness of Neisseria meningitidis into brain endothelial cells.

Simonis A, Hebling S, Gulbins E, Schneider-Schaulies S, Schubert-Unkmeir A.

PLoS Pathog. 2014 Jun 12;10(6):e1004160. doi: 10.1371/journal.ppat.1004160. eCollection 2014 Jun.

19.

Identification of human IKK-2 inhibitors of natural origin (part I): modeling of the IKK-2 kinase domain, virtual screening and activity assays.

Sala E, Guasch L, Iwaszkiewicz J, Mulero M, Salvadó MJ, Pinent M, Zoete V, Grosdidier A, Garcia-Vallvé S, Michielin O, Pujadas G.

PLoS One. 2011 Feb 24;6(2):e16903. doi: 10.1371/journal.pone.0016903.

20.

Biological activities of alpha-mangostin derivatives against acidic sphingomyelinase.

Hamada M, Iikubo K, Ishikawa Y, Ikeda A, Umezawa K, Nishiyama S.

Bioorg Med Chem Lett. 2003 Oct 6;13(19):3151-3.

PMID:
12951083

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