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The Trypanosoma cruzi protease cruzain mediates immune evasion.

Doyle PS, Zhou YM, Hsieh I, Greenbaum DC, McKerrow JH, Engel JC.

PLoS Pathog. 2011 Sep;7(9):e1002139. doi: 10.1371/journal.ppat.1002139. Epub 2011 Sep 1.


In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.

Chen YT, Brinen LS, Kerr ID, Hansell E, Doyle PS, McKerrow JH, Roush WR.

PLoS Negl Trop Dis. 2010 Sep 14;4(9). pii: e825. doi: 10.1371/journal.pntd.0000825.


Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi.

Engel JC, Doyle PS, Palmer J, Hsieh I, Bainton DF, McKerrow JH.

J Cell Sci. 1998 Mar;111 ( Pt 5):597-606.


The crystal structure of cruzain: a therapeutic target for Chagas' disease.

McGrath ME, Eakin AE, Engel JC, McKerrow JH, Craik CS, Fletterick RJ.

J Mol Biol. 1995 Mar 24;247(2):251-9.


Upregulation of the secretory pathway in cysteine protease inhibitor-resistant Trypanosoma cruzi.

Engel JC, Torres C, Hsieh I, Doyle PS, McKerrow JH.

J Cell Sci. 2000 Apr;113 ( Pt 8):1345-54. Erratum in: J Cell Sci 2000 Jul;113(Pt 14):2638. Garcia CT [corrected to Torres C].


Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway.

Cameron P, McGachy A, Anderson M, Paul A, Coombs GH, Mottram JC, Alexander J, Plevin R.

J Immunol. 2004 Sep 1;173(5):3297-304.


A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection.

Doyle PS, Zhou YM, Engel JC, McKerrow JH.

Antimicrob Agents Chemother. 2007 Nov;51(11):3932-9. Epub 2007 Aug 13.


A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi.

Barr SC, Warner KL, Kornreic BG, Piscitelli J, Wolfe A, Benet L, McKerrow JH.

Antimicrob Agents Chemother. 2005 Dec;49(12):5160-1.


Synthesis of macrocyclic trypanosomal cysteine protease inhibitors.

Chen YT, Lira R, Hansell E, McKerrow JH, Roush WR.

Bioorg Med Chem Lett. 2008 Nov 15;18(22):5860-3. doi: 10.1016/j.bmcl.2008.06.012. Epub 2008 Jun 10.


Cruzain : the path from target validation to the clinic.

Sajid M, Robertson SA, Brinen LS, McKerrow JH.

Adv Exp Med Biol. 2011;712:100-15. doi: 10.1007/978-1-4419-8414-2_7. Review.


Identification of a new class of nonpeptidic inhibitors of cruzain.

Brak K, Doyle PS, McKerrow JH, Ellman JA.

J Am Chem Soc. 2008 May 21;130(20):6404-10. doi: 10.1021/ja710254m. Epub 2008 Apr 25.


The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi.

Eakin AE, Mills AA, Harth G, McKerrow JH, Craik CS.

J Biol Chem. 1992 Apr 15;267(11):7411-20.


Peptide-fluoromethyl ketones arrest intracellular replication and intercellular transmission of Trypanosoma cruzi.

Harth G, Andrews N, Mills AA, Engel JC, Smith R, McKerrow JH.

Mol Biochem Parasitol. 1993 Mar;58(1):17-24.


Cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inhibitors.

Lima AP, dos Reis FC, Serveau C, Lalmanach G, Juliano L, Ménard R, Vernet T, Thomas DY, Storer AC, Scharfstein J.

Mol Biochem Parasitol. 2001 Apr 25;114(1):41-52.


Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection.

Engel JC, Doyle PS, Hsieh I, McKerrow JH.

J Exp Med. 1998 Aug 17;188(4):725-34.


Trypanosoma cruzi, the causative agent of Chagas disease, modulates interleukin-6-induced STAT3 phosphorylation via gp130 cleavage in different host cells.

Ponce NE, Carrera-Silva EA, Pellegrini AV, Cazorla SI, Malchiodi EL, Lima AP, Gea S, Aoki MP.

Biochim Biophys Acta. 2013 Mar;1832(3):485-94. doi: 10.1016/j.bbadis.2012.12.003. Epub 2012 Dec 16.


Inhibition of HIV-1 replication in human monocyte-derived macrophages by parasite Trypanosoma cruzi.

Andreani G, Celentano AM, Solana ME, Cazorla SI, Malchiodi EL, Martínez Peralta LA, Dolcini GL.

PLoS One. 2009 Dec 14;4(12):e8246. doi: 10.1371/journal.pone.0008246.


Glycoinositolphospholipids from Trypanosoma cruzi interfere with macrophages and dendritic cell responses.

Brodskyn C, Patricio J, Oliveira R, Lobo L, Arnholdt A, Mendonça-Previato L, Barral A, Barral-Netto M.

Infect Immun. 2002 Jul;70(7):3736-43.

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