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Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial.

Powell H, Murphy VE, Taylor DR, Hensley MJ, McCaffery K, Giles W, Clifton VL, Gibson PG.

Lancet. 2011 Sep 10;378(9795):983-90. doi: 10.1016/S0140-6736(11)60971-9.


The Breathing for Life Trial: a randomised controlled trial of fractional exhaled nitric oxide (FENO)-based management of asthma during pregnancy and its impact on perinatal outcomes and infant and childhood respiratory health.

Murphy VE, Jensen ME, Mattes J, Hensley MJ, Giles WB, Peek MJ, Bisits A, Callaway LK, McCaffery K, Barrett HL, Colditz PB, Seeho SK, Attia J, Searles A, Doran C, Powell H, Gibson PG.

BMC Pregnancy Childbirth. 2016 May 17;16:111. doi: 10.1186/s12884-016-0890-3.


Efficacy and safety of maintenance and reliever combination budesonide-formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial.

Patel M, Pilcher J, Pritchard A, Perrin K, Travers J, Shaw D, Holt S, Harwood M, Black P, Weatherall M, Beasley R; SMART Study Group.

Lancet Respir Med. 2013 Mar;1(1):32-42. doi: 10.1016/S2213-2600(13)70007-9. Epub 2013 Mar 4.


Beclometasone-formoterol as maintenance and reliever treatment in patients with asthma: a double-blind, randomised controlled trial.

Papi A, Corradi M, Pigeon-Francisco C, Baronio R, Siergiejko Z, Petruzzelli S, Fabbri LM, Rabe KF.

Lancet Respir Med. 2013 Mar;1(1):23-31. doi: 10.1016/S2213-2600(13)70012-2. Epub 2013 Mar 4.


Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma.

Kharitonov SA, Donnelly LE, Montuschi P, Corradi M, Collins JV, Barnes PJ.

Thorax. 2002 Oct;57(10):889-96.


Predictors of severe exacerbations, poor asthma control, and β-agonist overuse for patients with asthma.

Patel M, Pilcher J, Reddel HK, Qi V, Mackey B, Tranquilino T, Shaw D, Black P, Weatherall M, Beasley R; SMART Study Group.

J Allergy Clin Immunol Pract. 2014 Nov-Dec;2(6):751-8. doi: 10.1016/j.jaip.2014.06.001. Epub 2014 Jul 25.


Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial.

Martinez FJ, Calverley PM, Goehring UM, Brose M, Fabbri LM, Rabe KF.

Lancet. 2015 Mar 7;385(9971):857-66. doi: 10.1016/S0140-6736(14)62410-7. Epub 2015 Feb 13.


Switching from salmeterol/fluticasone to formoterol/budesonide combinations improves peripheral airway/alveolar inflammation in asthma.

Akamatsu T, Shirai T, Kato M, Yasui H, Hashimoto D, Fujisawa T, Tsuchiya T, Inui N, Suda T, Chida K.

Pulm Pharmacol Ther. 2014 Feb;27(1):52-6. doi: 10.1016/j.pupt.2013.04.001. Epub 2013 Apr 11.


Formoterol as needed with or without budesonide in patients with intermittent asthma and raised NO levels in exhaled air: A SOMA study.

Haahtela T, Tamminen K, Malmberg LP, Zetterström O, Karjalainen J, Ylä-Outinen H, Svahn T, Ekström T, Selroos O.

Eur Respir J. 2006 Oct;28(4):748-55.


Efficacy and safety of budesonide/formoterol single inhaler therapy versus a higher dose of budesonide in moderate to severe asthma.

Scicchitano R, Aalbers R, Ukena D, Manjra A, Fouquert L, Centanni S, Boulet LP, Naya IP, Hultquist C.

Curr Med Res Opin. 2004 Sep;20(9):1403-18.


Use of exhaled nitric oxide measurements to guide treatment in chronic asthma.

Smith AD, Cowan JO, Brassett KP, Herbison GP, Taylor DR.

N Engl J Med. 2005 May 26;352(21):2163-73. Epub 2005 May 24.


Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial.

Szefler SJ, Mitchell H, Sorkness CA, Gergen PJ, O'Connor GT, Morgan WJ, Kattan M, Pongracic JA, Teach SJ, Bloomberg GR, Eggleston PA, Gruchalla RS, Kercsmar CM, Liu AH, Wildfire JJ, Curry MD, Busse WW.

Lancet. 2008 Sep 20;372(9643):1065-72. doi: 10.1016/S0140-6736(08)61448-8.


Anti-inflammatory treatment of atopic asthma guided by exhaled nitric oxide: a randomized, controlled trial.

Syk J, Malinovschi A, Johansson G, Undén AL, Andreasson A, Lekander M, Alving K.

J Allergy Clin Immunol Pract. 2013 Nov-Dec;1(6):639-48.e1-8. doi: 10.1016/j.jaip.2013.07.013. Epub 2013 Oct 9.


Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps.

Bateman ED, Harrison TW, Quirce S, Reddel HK, Buhl R, Humbert M, Jenkins CR, Peterson S, Ostlund O, O'Byrne PM, Sears MR, Eriksson GS.

Respir Res. 2011 Apr 4;12:38. doi: 10.1186/1465-9921-12-38.


Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group.

Pauwels RA, Löfdahl CG, Postma DS, Tattersfield AE, O'Byrne P, Barnes PJ, Ullman A.

N Engl J Med. 1997 Nov 13;337(20):1405-11. Erratum in: N Engl J Med 1998 Jan 8;338(2):139.


Fractioned exhaled nitric oxide (FE(NO)) is not a sufficiently reliable test for monitoring asthma in pregnancy.

Nittner-Marszalska M, Liebhart J, Pawłowicz R, Kazimierczak A, Marszalska H, Kraus-Filarska M, Panaszek B, Dor-Wojnarowska A.

Nitric Oxide. 2013 Sep 1;33:56-63. doi: 10.1016/j.niox.2013.06.001. Epub 2013 Jun 10.


The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial.

Shaw DE, Berry MA, Thomas M, Green RH, Brightling CE, Wardlaw AJ, Pavord ID.

Am J Respir Crit Care Med. 2007 Aug 1;176(3):231-7. Epub 2007 May 11.


Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations: a randomised controlled, double-blind study.

Rabe KF, Atienza T, Magyar P, Larsson P, Jorup C, Lalloo UG.

Lancet. 2006 Aug 26;368(9537):744-53.


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