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Items: 1 to 20 of 211

1.

F508del-CFTR increases intracellular Ca(2+) signaling that causes enhanced calcium-dependent Cl(-) conductance in cystic fibrosis.

Martins JR, Kongsuphol P, Sammels E, Dahimène S, Aldehni F, Clarke LA, Schreiber R, de Smedt H, Amaral MD, Kunzelmann K.

Biochim Biophys Acta. 2011 Nov;1812(11):1385-92. doi: 10.1016/j.bbadis.2011.08.008. Epub 2011 Aug 30.

2.

Pseudomonas aeruginosa Homoserine lactone activates store-operated cAMP and cystic fibrosis transmembrane regulator-dependent Cl- secretion by human airway epithelia.

Schwarzer C, Wong S, Shi J, Matthes E, Illek B, Ianowski JP, Arant RJ, Isacoff E, Vais H, Foskett JK, Maiellaro I, Hofer AM, Machen TE.

J Biol Chem. 2010 Nov 5;285(45):34850-63. doi: 10.1074/jbc.M110.167668. Epub 2010 Aug 25.

3.

Anoctamin 1 dysregulation alters bronchial epithelial repair in cystic fibrosis.

Ruffin M, Voland M, Marie S, Bonora M, Blanchard E, Blouquit-Laye S, Naline E, Puyo P, Le Rouzic P, Guillot L, Corvol H, Clement A, Tabary O.

Biochim Biophys Acta. 2013 Dec;1832(12):2340-51. doi: 10.1016/j.bbadis.2013.09.012. Epub 2013 Sep 27.

4.

Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airway.

Liang L, MacDonald K, Schwiebert EM, Zeitlin PL, Guggino WB.

Am J Physiol Cell Physiol. 2009 Jan;296(1):C131-41. doi: 10.1152/ajpcell.00346.2008. Epub 2008 Nov 5.

5.

Abnormal spatial diffusion of Ca2+ in F508del-CFTR airway epithelial cells.

Antigny F, Norez C, Cantereau A, Becq F, Vandebrouck C.

Respir Res. 2008 Oct 30;9:70. doi: 10.1186/1465-9921-9-70.

6.
7.

Tgf-beta downregulation of distinct chloride channels in cystic fibrosis-affected epithelia.

Sun H, Harris WT, Kortyka S, Kotha K, Ostmann AJ, Rezayat A, Sridharan A, Sanders Y, Naren AP, Clancy JP.

PLoS One. 2014 Sep 30;9(9):e106842. doi: 10.1371/journal.pone.0106842. eCollection 2014.

8.

Transient receptor potential canonical channel 6 links Ca2+ mishandling to cystic fibrosis transmembrane conductance regulator channel dysfunction in cystic fibrosis.

Antigny F, Norez C, Dannhoffer L, Bertrand J, Raveau D, Corbi P, Jayle C, Becq F, Vandebrouck C.

Am J Respir Cell Mol Biol. 2011 Jan;44(1):83-90. doi: 10.1165/rcmb.2009-0347OC. Epub 2010 Mar 4.

PMID:
20203293
9.

CFTR induces extracellular acid sensing in Xenopus oocytes which activates endogenous Ca²⁺-activated Cl⁻ conductance.

Kongsuphol P, Schreiber R, Kraidith K, Kunzelmann K.

Pflugers Arch. 2011 Sep;462(3):479-87. doi: 10.1007/s00424-011-0983-9. Epub 2011 Jun 7.

PMID:
21647592
10.

CFTR: a hub for kinases and crosstalk of cAMP and Ca2+.

Kunzelmann K, Mehta A.

FEBS J. 2013 Sep;280(18):4417-29. doi: 10.1111/febs.12457. Epub 2013 Aug 27. Review.

11.

Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice.

Clarke LL, Grubb BR, Yankaskas JR, Cotton CU, McKenzie A, Boucher RC.

Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):479-83.

12.

ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel.

Barro-Soria R, Aldehni F, Almaça J, Witzgall R, Schreiber R, Kunzelmann K.

Pflugers Arch. 2010 Feb;459(3):485-97. doi: 10.1007/s00424-009-0745-0. Epub 2009 Oct 13.

PMID:
19823864
13.

Correction of chloride transport and mislocalization of CFTR protein by vardenafil in the gastrointestinal tract of cystic fibrosis mice.

Dhooghe B, Noël S, Bouzin C, Behets-Wydemans G, Leal T.

PLoS One. 2013 Oct 24;8(10):e77314. doi: 10.1371/journal.pone.0077314. eCollection 2013.

14.

CFTR and calcium-activated chloride channels in primary cultures of human airway gland cells of serous or mucous phenotype.

Fischer H, Illek B, Sachs L, Finkbeiner WE, Widdicombe JH.

Am J Physiol Lung Cell Mol Physiol. 2010 Oct;299(4):L585-94. doi: 10.1152/ajplung.00421.2009. Epub 2010 Jul 30.

15.

The effect of ambroxol on chloride transport, CFTR and ENaC in cystic fibrosis airway epithelial cells.

Varelogianni G, Hussain R, Strid H, Oliynyk I, Roomans GM, Johannesson M.

Cell Biol Int. 2013 Nov;37(11):1149-56. doi: 10.1002/cbin.10146. Epub 2013 Jul 23.

PMID:
23765701
16.

Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR.

Antigny F, Norez C, Becq F, Vandebrouck C.

Cell Calcium. 2008 Feb;43(2):175-83. Epub 2007 Jun 27.

PMID:
17590432
17.

Improvement of chloride transport defect by gonadotropin-releasing hormone (GnRH) in cystic fibrosis epithelial cells.

Benz N, Le Hir S, Norez C, Kerbiriou M, Calvez ML, Becq F, Trouvé P, Férec C.

PLoS One. 2014 Feb 19;9(2):e88964. doi: 10.1371/journal.pone.0088964. eCollection 2014.

19.

Correction of delF508-CFTR activity with benzo(c)quinolizinium compounds through facilitation of its processing in cystic fibrosis airway cells.

Dormer RL, Dérand R, McNeilly CM, Mettey Y, Bulteau-Pignoux L, Métayé T, Vierfond JM, Gray MA, Galietta LJ, Morris MR, Pereira MM, Doull IJ, Becq F, McPherson MA.

J Cell Sci. 2001 Nov;114(Pt 22):4073-81.

20.

Rescue of functional F508del cystic fibrosis transmembrane conductance regulator by vasoactive intestinal peptide in the human nasal epithelial cell line JME/CF15.

Rafferty S, Alcolado N, Norez C, Chappe F, Pelzer S, Becq F, Chappe V.

J Pharmacol Exp Ther. 2009 Oct;331(1):2-13. doi: 10.1124/jpet.109.155341. Epub 2009 Jul 7.

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