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Items: 1 to 20 of 129

1.

Ferrocenyl chalcone difluoridoborates inhibit HIV-1 integrase and display low activity towards cancer and endothelial cells.

Monserrat JP, Al-Safi RI, Tiwari KN, Quentin L, Chabot GG, Vessières A, Jaouen G, Neamati N, Hillard EA.

Bioorg Med Chem Lett. 2011 Oct 15;21(20):6195-7. doi: 10.1016/j.bmcl.2011.07.078.

PMID:
21889342
2.

Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore.

Deng J, Sanchez T, Al-Mawsawi LQ, Dayam R, Yunes RA, Garofalo A, Bolger MB, Neamati N.

Bioorg Med Chem. 2007 Jul 15;15(14):4985-5002.

PMID:
17502148
3.

Rational design of 2-pyrrolinones as inhibitors of HIV-1 integrase.

Ma K, Wang P, Fu W, Wan X, Zhou L, Chu Y, Ye D.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6724-7. doi: 10.1016/j.bmcl.2011.09.054.

PMID:
21996518
4.

Design, synthesis and biological activity of aromatic diketone derivatives as HIV-1 integrase inhibitors.

Hu L, Li Z, Wang Z, Liu G, He X, Wang X, Zeng C.

Med Chem. 2015;11(2):180-7.

PMID:
25173788
5.

Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors.

Sharma H, Patil S, Sanchez TW, Neamati N, Schinazi RF, Buolamwini JK.

Bioorg Med Chem. 2011 Mar 15;19(6):2030-45. doi: 10.1016/j.bmc.2011.01.047.

6.

Synthesis of polyhydroxylated aromatics having amidation of piperazine nitrogen as HIV-1 integrase inhibitor.

Yang L, Xu X, Huang Y, Zhang B, Zeng C, He H, Wang C, Hu L.

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5469-71. doi: 10.1016/j.bmcl.2010.07.087.

PMID:
20709544
7.

Chemical modification of coumarin dimer and HIV-1 integrase inhibitory activity.

Mao PC, Mouscadet JF, Leh H, Auclair C, Hsu LY.

Chem Pharm Bull (Tokyo). 2002 Dec;50(12):1634-7.

8.

Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore.

Walker MA, Johnson T, Ma Z, Banville J, Remillard R, Kim O, Zhang Y, Staab A, Wong H, Torri A, Samanta H, Lin Z, Deminie C, Terry B, Krystal M, Meanwell N.

Bioorg Med Chem Lett. 2006 Jun 1;16(11):2920-4.

PMID:
16546383
9.

Azaindole hydroxamic acids are potent HIV-1 integrase inhibitors.

Plewe MB, Butler SL, Dress KR, Hu Q, Johnson TW, Kuehler JE, Kuki A, Lam H, Liu W, Nowlin D, Peng Q, Rahavendran SV, Tanis SP, Tran KT, Wang H, Yang A, Zhang J.

J Med Chem. 2009 Nov 26;52(22):7211-9. doi: 10.1021/jm900862n.

PMID:
19873974
10.

New 2-arylnaphthalenediols and triol inhibitors of HIV-1 integrase--discovery of a new polyhydroxylated antiviral agent.

Maurin C, Lion C, Bailly F, Touati N, Vezin H, Mbemba G, Mouscadet JF, Debyser Z, Witvrouw M, Cotelle P.

Bioorg Med Chem. 2010 Jul 15;18(14):5194-201. doi: 10.1016/j.bmc.2010.05.059.

PMID:
20541944
11.

Design, synthesis, and anti-integrase activity of catechol-DKA hybrids.

Maurin C, Bailly F, Mbemba G, Mouscadet JF, Cotelle P.

Bioorg Med Chem. 2006 May 1;14(9):2978-84.

PMID:
16412645
12.
13.

Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors.

Al-Mawsawi LQ, Dayam R, Taheri L, Witvrouw M, Debyser Z, Neamati N.

Bioorg Med Chem Lett. 2007 Dec 1;17(23):6472-5.

PMID:
17950601
14.

Discovery of inhibitors to block interactions of HIV-1 integrase with human LEDGF/p75 via structure-based virtual screening and bioassays.

Hu G, Li X, Zhang X, Li Y, Ma L, Yang LM, Liu G, Li W, Huang J, Shen X, Hu L, Zheng YT, Tang Y.

J Med Chem. 2012 Nov 26;55(22):10108-17. doi: 10.1021/jm301226a.

PMID:
23046280
15.

Design and synthesis of N-methylpyrimidone derivatives as HIV-1 integrase inhibitors.

Wang Y, Rong J, Zhang B, Hu L, Wang X, Zeng C.

Bioorg Med Chem. 2015 Feb 15;23(4):735-41. doi: 10.1016/j.bmc.2014.12.059.

PMID:
25618597
16.

Design and synthesis of novel nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors from caffeic acid phenethyl ester.

Wang P, Liu C, Sanches T, Zhong Y, Liu B, Xiong J, Neamati N, Zhao G.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4574-8. doi: 10.1016/j.bmcl.2009.06.100.

PMID:
19625188
17.

Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors.

Langford HM, Williams PD, Homnick CF, Vacca JP, Felock PJ, Stillmock KA, Witmer MV, Hazuda DJ, Gabryelski LJ, Schleif WA.

Bioorg Med Chem Lett. 2008 Jan 15;18(2):721-5.

PMID:
18078751
18.

2,6-Bis(3,4,5-trihydroxybenzylydene) derivatives of cyclohexanone: novel potent HIV-1 integrase inhibitors that prevent HIV-1 multiplication in cell-based assays.

Costi R, Santo RD, Artico M, Massa S, Ragno R, Loddo R, La Colla M, Tramontano E, La Colla P, Pani A.

Bioorg Med Chem. 2004 Jan 2;12(1):199-215.

PMID:
14697785
19.

Synthesis, antiviral, and anti-HIV-1 integrase activities of 3-aroyl-1,1-dioxo-1,4,2-benzodithiazines.

Brzozowski Z, Saczewski F, Sanchez T, Kuo CL, Gdaniec M, Neamati N.

Bioorg Med Chem. 2004 Jul 1;12(13):3663-72.

PMID:
15186851
20.

Novel furocoumarins as potential HIV-1 integrase inhibitors.

Olomola TO, Mosebi S, Klein R, Traut-Johnstone T, Coates J, Hewer R, Kaye PT.

Bioorg Chem. 2014 Dec;57:1-4. doi: 10.1016/j.bioorg.2014.07.008.

PMID:
25159595
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