Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 512

1.

Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.

Coppé JP, Rodier F, Patil CK, Freund A, Desprez PY, Campisi J.

J Biol Chem. 2011 Oct 21;286(42):36396-403. doi: 10.1074/jbc.M111.257071. Epub 2011 Aug 31.

2.

Single-cell analysis of p16(INK4a) and p21(WAF1) expression suggests distinct mechanisms of senescence in normal human and Li-Fraumeni Syndrome fibroblasts.

Mirzayans R, Andrais B, Scott A, Paterson MC, Murray D.

J Cell Physiol. 2010 Apr;223(1):57-67. doi: 10.1002/jcp.22002.

PMID:
20039273
3.

p21Waf1/Cip1 plays a critical role in modulating senescence through changes of DNA methylation.

Zheng QH, Ma LW, Zhu WG, Zhang ZY, Tong TJ.

J Cell Biochem. 2006 Aug 1;98(5):1230-48.

PMID:
16514663
4.
5.

Two mechanisms underlying the loss of p16(Ink4a) function are associated with distinct tumorigenic consequences for WS MEFs escaping from senescence.

Wu X, Jia S, Zhang X, Si X, Tang W, Luo Y.

Mech Ageing Dev. 2012 Aug;133(8):549-55. doi: 10.1016/j.mad.2012.07.002. Epub 2012 Jul 16.

PMID:
22813853
6.

The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence.

Haferkamp S, Tran SL, Becker TM, Scurr LL, Kefford RF, Rizos H.

Aging (Albany NY). 2009 May 16;1(6):542-56.

7.

Long-term growth arrest of PUVA-treated fibroblasts in G2/M in the absence of p16(INK4a) p21(CIP1) or p53.

Ma W, Hommel C, Brenneisen P, Peters T, Smit N, Sedivy J, Scharffetter-Kochanek K, Wlaschek M.

Exp Dermatol. 2003 Oct;12(5):629-37.

PMID:
14705804
8.

CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms.

Ruas M, Gregory F, Jones R, Poolman R, Starborg M, Rowe J, Brookes S, Peters G.

Mol Cell Biol. 2007 Jun;27(12):4273-82. Epub 2007 Apr 9.

9.

E2FBP1 antagonizes the p16(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability.

Fukuyo Y, Takahashi A, Hara E, Horikoshi N, Pandita TK, Nakajima T.

Int J Oral Sci. 2011 Oct;3(4):200-8. doi: 10.4248/IJOS11071.

10.

Contribution of p16(INK4a) to replicative senescence of human fibroblasts.

Brookes S, Rowe J, Gutierrez Del Arroyo A, Bond J, Peters G.

Exp Cell Res. 2004 Aug 15;298(2):549-59.

PMID:
15265701
11.

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis.

Capparelli C, Chiavarina B, Whitaker-Menezes D, Pestell TG, Pestell RG, Hulit J, Andò S, Howell A, Martinez-Outschoorn UE, Sotgia F, Lisanti MP.

Cell Cycle. 2012 Oct 1;11(19):3599-610. doi: 10.4161/cc.21884. Epub 2012 Aug 30.

12.

Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism.

Wang R, Yu Z, Sunchu B, Shoaf J, Dang I, Zhao S, Caples K, Bradley L, Beaver LM, Ho E, Löhr CV, Perez VI.

Aging Cell. 2017 Jun;16(3):564-574. doi: 10.1111/acel.12587. Epub 2017 Mar 31.

13.

Resistance of primary cultured mouse hepatic tumor cells to cellular senescence despite expression of p16(Ink4a), p19(Arf), p53, and p21(Waf1/Cip1).

Obata M, Imamura E, Yoshida Y, Goto J, Kishibe K, Yasuda A, Ogawa K.

Mol Carcinog. 2001 Sep;32(1):9-18.

PMID:
11568971
14.

Senescence of human fibroblasts induced by oncogenic Raf.

Zhu J, Woods D, McMahon M, Bishop JM.

Genes Dev. 1998 Oct 1;12(19):2997-3007.

15.

Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence.

Shin J, Yang J, Lee JC, Baek KH.

Cell Signal. 2013 Dec;25(12):2540-7. doi: 10.1016/j.cellsig.2013.08.014. Epub 2013 Aug 30.

PMID:
23993963
16.

Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells.

Douville JM, Cheung DY, Herbert KL, Moffatt T, Wigle JT.

PLoS One. 2011;6(12):e29099. doi: 10.1371/journal.pone.0029099. Epub 2011 Dec 20.

17.

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a).

Kosar M, Bartkova J, Hubackova S, Hodny Z, Lukas J, Bartek J.

Cell Cycle. 2011 Feb 1;10(3):457-68. Epub 2011 Feb 1.

PMID:
21248468
18.

Expression of senescence-related genes in human corneal endothelial cells.

Song Z, Wang Y, Xie L, Zang X, Yin H.

Mol Vis. 2008 Jan 29;14:161-70.

19.

Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo.

Takeuchi S, Takahashi A, Motoi N, Yoshimoto S, Tajima T, Yamakoshi K, Hirao A, Yanagi S, Fukami K, Ishikawa Y, Sone S, Hara E, Ohtani N.

Cancer Res. 2010 Nov 15;70(22):9381-90. doi: 10.1158/0008-5472.CAN-10-0801. Epub 2010 Nov 9.

20.

Supplemental Content

Support Center