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Development of quantitative DNA cleavage assay for XPG endonuclease activity using endogenous nuclear proteins in human cell lines.

Koedrith P, Seo YR.

Oncol Rep. 2011 Nov;26(5):1235-41. doi: 10.3892/or.2011.1424. Epub 2011 Aug 18.


Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency.

Barnhoorn S, Uittenboogaard LM, Jaarsma D, Vermeij WP, Tresini M, Weymaere M, Menoni H, Brandt RM, de Waard MC, Botter SM, Sarker AH, Jaspers NG, van der Horst GT, Cooper PK, Hoeijmakers JH, van der Pluijm I.

PLoS Genet. 2014 Oct 9;10(10):e1004686. doi: 10.1371/journal.pgen.1004686. eCollection 2014 Oct.


p300/CBP acetyl transferases interact with and acetylate the nucleotide excision repair factor XPG.

Tillhon M, Cazzalini O, Nardo T, Necchi D, Sommatis S, Stivala LA, Scovassi AI, Prosperi E.

DNA Repair (Amst). 2012 Oct 1;11(10):844-52. doi: 10.1016/j.dnarep.2012.08.001. Epub 2012 Sep 3.


Recruitment of the nucleotide excision repair endonuclease XPG to sites of UV-induced dna damage depends on functional TFIIH.

Zotter A, Luijsterburg MS, Warmerdam DO, Ibrahim S, Nigg A, van Cappellen WA, Hoeijmakers JH, van Driel R, Vermeulen W, Houtsmuller AB.

Mol Cell Biol. 2006 Dec;26(23):8868-79. Epub 2006 Sep 25.


The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome.

Trego KS, Chernikova SB, Davalos AR, Perry JJ, Finger LD, Ng C, Tsai MS, Yannone SM, Tainer JA, Campisi J, Cooper PK.

Cell Cycle. 2011 Jun 15;10(12):1998-2007. Epub 2011 Jun 15.


Cyclosporin A inhibits nucleotide excision repair via downregulation of the xeroderma pigmentosum group A and G proteins, which is mediated by calcineurin inhibition.

Kuschal C, Thoms KM, Boeckmann L, Laspe P, Apel A, Schön MP, Emmert S.

Exp Dermatol. 2011 Oct;20(10):795-9. doi: 10.1111/j.1600-0625.2011.01320.x. Epub 2011 Jun 24.


Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity.

Hohl M, Dunand-Sauthier I, Staresincic L, Jaquier-Gubler P, Thorel F, Modesti M, Clarkson SG, Schärer OD.

Nucleic Acids Res. 2007;35(9):3053-63. Epub 2007 Apr 22.


The non-catalytic function of XPG protein during dual incision in human nucleotide excision repair.

Wakasugi M, Reardon JT, Sancar A.

J Biol Chem. 1997 Jun 20;272(25):16030-4.


Conserved residues of human XPG protein important for nuclease activity and function in nucleotide excision repair.

Constantinou A, Gunz D, Evans E, Lalle P, Bates PA, Wood RD, Clarkson SG.

J Biol Chem. 1999 Feb 26;274(9):5637-48.


Suppression of UV-induced apoptosis by the human DNA repair protein XPG.

Clément V, Dunand-Sauthier I, Clarkson SG.

Cell Death Differ. 2006 Mar;13(3):478-88.


Structural determinants for substrate binding and catalysis by the structure-specific endonuclease XPG.

Hohl M, Thorel F, Clarkson SG, Schärer OD.

J Biol Chem. 2003 May 23;278(21):19500-8. Epub 2003 Mar 18.


Down-regulation of the nucleotide excision repair gene XPG as a new mechanism of drug resistance in human and murine cancer cells.

Sabatino MA, Marabese M, Ganzinelli M, Caiola E, Geroni C, Broggini M.

Mol Cancer. 2010 Sep 24;9:259. doi: 10.1186/1476-4598-9-259.


The founding members of xeroderma pigmentosum group G produce XPG protein with severely impaired endonuclease activity.

Lalle P, Nouspikel T, Constantinou A, Thorel F, Clarkson SG.

J Invest Dermatol. 2002 Feb;118(2):344-51.


Characterization of a putative helix-loop-helix motif in nucleotide excision repair endonuclease, XPG.

Park MS, Valdez J, Gurley L, Kim CY.

J Biol Chem. 1997 Oct 31;272(44):27823-9.


Irofulven cytotoxicity depends on transcription-coupled nucleotide excision repair and is correlated with XPG expression in solid tumor cells.

Koeppel F, Poindessous V, Lazar V, Raymond E, Sarasin A, Larsen AK.

Clin Cancer Res. 2004 Aug 15;10(16):5604-13.


Novel functional interactions between nucleotide excision DNA repair proteins influencing the enzymatic activities of TFIIH, XPG, and ERCC1-XPF.

Winkler GS, Sugasawa K, Eker AP, de Laat WL, Hoeijmakers JH.

Biochemistry. 2001 Jan 9;40(1):160-5.


Roles of XPG and XPF/ERCC1 endonucleases in UV-induced immunostaining of PCNA in fibroblasts.

Miura M, Nakamura S, Sasaki T, Takasaki Y, Shiomi T, Yamaizumi M.

Exp Cell Res. 1996 Jul 10;226(1):126-32.


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