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Items: 1 to 20 of 142


Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity.

Kofoed EM, Vance RE.

Nature. 2011 Aug 28;477(7366):592-5. doi: 10.1038/nature10394.


The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.

Zhao Y, Yang J, Shi J, Gong YN, Lu Q, Xu H, Liu L, Shao F.

Nature. 2011 Sep 14;477(7366):596-600. doi: 10.1038/nature10510.


Differential requirements for NAIP5 in activation of the NLRC4 inflammasome.

Lightfield KL, Persson J, Trinidad NJ, Brubaker SW, Kofoed EM, Sauer JD, Dunipace EA, Warren SE, Miao EA, Vance RE.

Infect Immun. 2011 Apr;79(4):1606-14. doi: 10.1128/IAI.01187-10.


Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ.

Suzuki S, Franchi L, He Y, Muñoz-Planillo R, Mimuro H, Suzuki T, Sasakawa C, Núñez G.

PLoS Pathog. 2014 Feb 6;10(2):e1003926. doi: 10.1371/journal.ppat.1003926.


Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.

von Moltke J, Trinidad NJ, Moayeri M, Kintzer AF, Wang SB, van Rooijen N, Brown CR, Krantz BA, Leppla SH, Gronert K, Vance RE.

Nature. 2012 Oct 4;490(7418):107-11. doi: 10.1038/nature11351.


Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellin.

Halff EF, Diebolder CA, Versteeg M, Schouten A, Brondijk TH, Huizinga EG.

J Biol Chem. 2012 Nov 9;287(46):38460-72. doi: 10.1074/jbc.M112.393512.


Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.

Zhang L, Chen S, Ruan J, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y, Wu H.

Science. 2015 Oct 23;350(6259):404-9. doi: 10.1126/science.aac5789.


Sensing bacterial infections by NAIP receptors in NLRC4 inflammasome activation.

Gong YN, Shao F.

Protein Cell. 2012 Feb;3(2):98-105. doi: 10.1007/s13238-012-2028-3. Review.


Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5.

Matusiak M, Van Opdenbosch N, Vande Walle L, Sirard JC, Kanneganti TD, Lamkanfi M.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1541-6. doi: 10.1073/pnas.1417945112.


The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus.

Zhao Y, Shao F.

Immunol Rev. 2015 May;265(1):85-102. doi: 10.1111/imr.12293. Review.


Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation.

Yang J, Zhao Y, Shi J, Shao F.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14408-13. doi: 10.1073/pnas.1306376110.


Structural and biochemical basis for induced self-propagation of NLRC4.

Hu Z, Zhou Q, Zhang C, Fan S, Cheng W, Zhao Y, Shao F, Wang HW, Sui SF, Chai J.

Science. 2015 Oct 23;350(6259):399-404. doi: 10.1126/science.aac5489.


A novel pathway for inducible nitric-oxide synthase activation through inflammasomes.

Buzzo CL, Campopiano JC, Massis LM, Lage SL, Cassado AA, Leme-Souza R, Cunha LD, Russo M, Zamboni DS, Amarante-Mendes GP, Bortoluci KR.

J Biol Chem. 2010 Oct 15;285(42):32087-95. doi: 10.1074/jbc.M110.124297.


Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes.

Tenthorey JL, Kofoed EM, Daugherty MD, Malik HS, Vance RE.

Mol Cell. 2014 Apr 10;54(1):17-29. doi: 10.1016/j.molcel.2014.02.018.


Emerging Concepts about NAIP/NLRC4 Inflammasomes.

Lage SL, Longo C, Branco LM, da Costa TB, Buzzo Cde L, Bortoluci KR.

Front Immunol. 2014 Jul 2;5:309. doi: 10.3389/fimmu.2014.00309. Review.


Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes.

Maier NK, Crown D, Liu J, Leppla SH, Moayeri M.

J Immunol. 2014 Jan 15;192(2):763-70. doi: 10.4049/jimmunol.1301434.


The NAIP/NLRC4 inflammasomes.

Vance RE.

Curr Opin Immunol. 2015 Feb;32:84-9. doi: 10.1016/j.coi.2015.01.010. Review.


β-arrestin1 is critical for the full activation of NLRP3 and NLRC4 inflammasomes.

Mao K, Chen S, Wang Y, Zeng Y, Ma Y, Hu Y, Zhang H, Sun S, Wu X, Meng G, Pei G, Sun B.

J Immunol. 2015 Feb 15;194(4):1867-73. doi: 10.4049/jimmunol.1401989.


Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin.

Kortmann J, Brubaker SW, Monack DM.

J Immunol. 2015 Aug 1;195(3):815-9. doi: 10.4049/jimmunol.1403100.

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