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Items: 1 to 20 of 115

1.

Design and synthesis of (+)-discodermolide-paclitaxel hybrids leading to enhanced biological activity.

Smith AB, Sugasawa K, Atasoylu O, Yang CP, Horwitz SB.

J Med Chem. 2011 Sep 22;54(18):6319-27. doi: 10.1021/jm200692n. Epub 2011 Aug 26.

2.

Total synthesis and biological evaluation of a series of macrocyclic hybrids and analogues of the antimitotic natural products dictyostatin, discodermolide, and taxol.

Paterson I, Naylor GJ, Gardner NM, Guzmán E, Wright AE.

Chem Asian J. 2011 Feb 1;6(2):459-73. doi: 10.1002/asia.201000541. Epub 2010 Oct 28.

3.

Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.

Paterson I, Naylor GJ, Wright AE.

Chem Commun (Camb). 2008 Oct 14;(38):4628-30. doi: 10.1039/b811575c. Epub 2008 Aug 28.

PMID:
18815706
4.

Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin.

Paterson I, Naylor GJ, Fujita T, Guzmán E, Wright AE.

Chem Commun (Camb). 2010 Jan 14;46(2):261-3. doi: 10.1039/b921237j. Epub 2009 Nov 24.

PMID:
20024345
5.

Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide.

Smith AB 3rd, Freeze BS, Lamarche MJ, Hirose T, Brouard I, Rucker PV, Xian M, Sundermann KF, Shaw SJ, Burlingame MA, Horwitz SB, Myles DC.

Org Lett. 2005 Jan 20;7(2):311-4.

PMID:
15646985
6.

Design, total synthesis, and evaluation of C13-C14 cyclopropane analogues of (+)-discodermolide.

Smith AB 3rd, Xian M, Liu F.

Org Lett. 2005 Oct 13;7(21):4613-6.

PMID:
16209492
8.

Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach.

Canales A, Rodríguez-Salarichs J, Trigili C, Nieto L, Coderch C, Andreu JM, Paterson I, Jiménez-Barbero J, Díaz JF.

ACS Chem Biol. 2011 Aug 19;6(8):789-99. doi: 10.1021/cb200099u. Epub 2011 May 13.

PMID:
21539341
9.

Simplified discodermolide analogues: synthesis and biological evaluation of 4-epi-7-dehydroxy-14,16-didemethyl-(+)-discodermolides as microtubule-stabilizing agents.

Choy N, Shin Y, Nguyen PQ, Curran DP, Balachandran R, Madiraju C, Day BW.

J Med Chem. 2003 Jul 3;46(14):2846-64.

PMID:
12825928
10.

Synthetic analogues of the microtubule-stabilizing agent (+)-discodermolide: preparation and biological activity.

Gunasekera SP, Mickel SJ, Daeffler R, Niederer D, Wright AE, Linley P, Pitts T.

J Nat Prod. 2004 May;67(5):749-56.

PMID:
15165132
11.

(+)-discodermolide: a marine natural product against cancer.

De Souza MV.

ScientificWorldJournal. 2004 Jun 11;4:415-36. Review.

12.

Total synthesis of the potent microtubule-stabilizing agent (+)-discodermolide.

Harried SS, Lee CP, Yang G, Lee TI, Myles DC.

J Org Chem. 2003 Aug 22;68(17):6646-60.

PMID:
12919029
13.

A photoaffinity analogue of discodermolide specifically labels a peptide in beta-tubulin.

Xia S, Kenesky CS, Rucker PV, Smith AB 3rd, Orr GA, Horwitz SB.

Biochemistry. 2006 Oct 3;45(39):11762-75.

PMID:
17002277
14.

The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies.

Martello LA, LaMarche MJ, He L, Beauchamp TJ, Smith AB, Horwitz SB.

Chem Biol. 2001 Sep;8(9):843-55.

15.

Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues.

Burlingame MA, Shaw SJ, Sundermann KF, Zhang D, Petryka J, Mendoza E, Liu F, Myles DC, LaMarche MJ, Hirose T, Scott Freeze B, Smith AB 3rd.

Bioorg Med Chem Lett. 2004 May 3;14(9):2335-8.

PMID:
15081036
16.

Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.

Madiraju C, Edler MC, Hamel E, Raccor BS, Balachandran R, Zhu G, Giuliano KA, Vogt A, Shin Y, Fournier JH, Fukui Y, Brückner AM, Curran DP, Day BW.

Biochemistry. 2005 Nov 15;44(45):15053-63.

PMID:
16274252
17.

Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin.

Florence GJ, Gardner NM, Paterson I.

Nat Prod Rep. 2008 Apr;25(2):342-75. doi: 10.1039/b705661n. Epub 2008 Feb 27. Review.

PMID:
18389141
18.

Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization.

Khrapunovich-Baine M, Menon V, Verdier-Pinard P, Smith AB 3rd, Angeletti RH, Fiser A, Horwitz SB, Xiao H.

Biochemistry. 2009 Dec 15;48(49):11664-77. doi: 10.1021/bi901351q.

19.

The structure activity relationship of discodermolide analogues.

Shaw SJ.

Mini Rev Med Chem. 2008 Mar;8(3):276-84. Review.

PMID:
18336347
20.

Toward understanding how the lactone moiety of discodermolide affects activity.

Shaw SJ, Sundermann KF, Burlingame MA, Myles DC, Freeze BS, Xian M, Brouard I, Smith AB 3rd.

J Am Chem Soc. 2005 May 11;127(18):6532-3.

PMID:
15869264

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