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739 results

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Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis.

Tanaka K, Kanno T, Yanagisawa Y, Yasutake K, Hadano S, Yoshii F, Ikeda JE. Tanaka K, et al. Exp Neurol. 2011 Nov;232(1):41-52. doi: 10.1016/j.expneurol.2011.08.001. Epub 2011 Aug 16. Exp Neurol. 2011. PMID: 21867702

Loss of glial fibrillary acidic protein marginally accelerates disease progression in a SOD1(H46R) transgenic mouse model of ALS.

Yoshii Y, Otomo A, Pan L, Ohtsuka M, Hadano S. Yoshii Y, et al. Neurosci Res. 2011 Jul;70(3):321-9. doi: 10.1016/j.neures.2011.03.006. Epub 2011 Mar 29. Neurosci Res. 2011. PMID: 21453731

A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice.

Tanaka K, Okada Y, Kanno T, Otomo A, Yanagisawa Y, Shouguchi-Miyata J, Suga E, Kohiki E, Onoe K, Osuga H, Aoki M, Hadano S, Itoyama Y, Ikeda JE. Tanaka K, et al. Exp Neurol. 2008 Jun;211(2):378-86. doi: 10.1016/j.expneurol.2008.02.004. Epub 2008 Mar 4. Exp Neurol. 2008. PMID: 18423451

Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1^H46R-expressing ALS mouse model.

Mitsui S, Otomo A, Nozaki M, Ono S, Sato K, Shirakawa R, Adachi H, Aoki M, Sobue G, Shang HF, Hadano S. Mitsui S, et al. Mol Brain. 2018 May 29;11(1):30. doi: 10.1186/s13041-018-0373-8. Mol Brain. 2018. PMID: 29843805 Free PMC article.

Toll-Like Receptor-4 Inhibitor TAK-242 Attenuates Motor Dysfunction and Spinal Cord Pathology in an Amyotrophic Lateral Sclerosis Mouse Model.

Fellner A, Barhum Y, Angel A, Perets N, Steiner I, Offen D, Lev N. Fellner A, et al. Int J Mol Sci. 2017 Aug 1;18(8):1666. doi: 10.3390/ijms18081666. Int J Mol Sci. 2017. PMID: 28763002 Free PMC article.

Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation.

Peviani M, Salvaneschi E, Bontempi L, Petese A, Manzo A, Rossi D, Salmona M, Collina S, Bigini P, Curti D. Peviani M, et al. Neurobiol Dis. 2014 Feb;62:218-32. doi: 10.1016/j.nbd.2013.10.010. Epub 2013 Oct 16. Neurobiol Dis. 2014. PMID: 24141020

DL-3-n-butylphthalide extends survival by attenuating glial activation in a mouse model of amyotrophic lateral sclerosis.

Feng X, Peng Y, Liu M, Cui L. Feng X, et al. Neuropharmacology. 2012 Feb;62(2):1004-10. doi: 10.1016/j.neuropharm.2011.10.009. Epub 2011 Nov 2. Neuropharmacology. 2012. PMID: 22056419

Human glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 mouse model of ALS.

Lepore AC, O'Donnell J, Kim AS, Williams T, Tuteja A, Rao MS, Kelley LL, Campanelli JT, Maragakis NJ. Lepore AC, et al. PLoS One. 2011;6(10):e25968. doi: 10.1371/journal.pone.0025968. Epub 2011 Oct 5. PLoS One. 2011. PMID: 21998733 Free PMC article.

A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway: therapeutic implications for ALS.

Kanno T, Tanaka K, Yanagisawa Y, Yasutake K, Hadano S, Yoshii F, Hirayama N, Ikeda JE. Kanno T, et al. Free Radic Biol Med. 2012 Dec 1;53(11):2028-42. doi: 10.1016/j.freeradbiomed.2012.09.010. Epub 2012 Sep 20. Free Radic Biol Med. 2012. PMID: 23000247

Knocking down metabotropic glutamate receptor 1 improves survival and disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Milanese M, Giribaldi F, Melone M, Bonifacino T, Musante I, Carminati E, Rossi PI, Vergani L, Voci A, Conti F, Puliti A, Bonanno G. Milanese M, et al. Neurobiol Dis. 2014 Apr;64:48-59. doi: 10.1016/j.nbd.2013.11.006. Epub 2013 Dec 19. Neurobiol Dis. 2014. PMID: 24361555 Free article.

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