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Items: 1 to 20 of 139


Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32.

Francis SP, Kramarenko II, Brandon CS, Lee FS, Baker TG, Cunningham LL.

Cell Death Dis. 2011 Aug 25;2:e195. doi: 10.1038/cddis.2011.76.


Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death.

Taleb M, Brandon CS, Lee FS, Harris KC, Dillmann WH, Cunningham LL.

Cell Stress Chaperones. 2009 Jul;14(4):427-37. doi: 10.1007/s12192-008-0097-2.


Hsp70 inhibits aminoglycoside-induced hair cell death and is necessary for the protective effect of heat shock.

Taleb M, Brandon CS, Lee FS, Lomax MI, Dillmann WH, Cunningham LL.

J Assoc Res Otolaryngol. 2008 Sep;9(3):277-89. doi: 10.1007/s10162-008-0122-2.


Sound preconditioning therapy inhibits ototoxic hearing loss in mice.

Roy S, Ryals MM, Van den Bruele AB, Fitzgerald TS, Cunningham LL.

J Clin Invest. 2013 Nov;123(11):4945-9. Erratum in: J Clin Invest. 2014 Jan 2;124(1):461.


Heat shock inhibits both aminoglycoside- and cisplatin-induced sensory hair cell death.

Cunningham LL, Brandon CS.

J Assoc Res Otolaryngol. 2006 Sep;7(3):299-307.


Heat shock protein-mediated protection against Cisplatin-induced hair cell death.

Baker TG, Roy S, Brandon CS, Kramarenko IK, Francis SP, Taleb M, Marshall KM, Schwendener R, Lee FS, Cunningham LL.

J Assoc Res Otolaryngol. 2015 Feb;16(1):67-80. doi: 10.1007/s10162-014-0491-7.


A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss.

Wang J, Van De Water TR, Bonny C, de Ribaupierre F, Puel JL, Zine A.

J Neurosci. 2003 Sep 17;23(24):8596-607.


Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure.

Polesskaya O, Cunningham LL, Francis SP, Luebke AE, Zhu X, Collins D, Vasilyeva ON, Sahler J, Desmet EA, Gelbard HA, Maggirwar SB, Walton JP, Frisina RD Jr, Dewhurst S.

Hear Res. 2010 Dec 1;270(1-2):21-7. doi: 10.1016/j.heares.2010.10.008.


Inner ear supporting cells protect hair cells by secreting HSP70.

May LA, Kramarenko II, Brandon CS, Voelkel-Johnson C, Roy S, Truong K, Francis SP, Monzack EL, Lee FS, Cunningham LL.

J Clin Invest. 2013 Aug;123(8):3577-87. doi: 10.1172/JCI68480.


A novel role of cytosolic protein synthesis inhibition in aminoglycoside ototoxicity.

Francis SP, Katz J, Fanning KD, Harris KA, Nicholas BD, Lacy M, Pagana J, Agris PF, Shin JB.

J Neurosci. 2013 Feb 13;33(7):3079-93. doi: 10.1523/JNEUROSCI.3430-12.2013.


Blocking c-Jun-N-terminal kinase signaling can prevent hearing loss induced by both electrode insertion trauma and neomycin ototoxicity.

Eshraghi AA, Wang J, Adil E, He J, Zine A, Bublik M, Bonny C, Puel JL, Balkany TJ, Van De Water TR.

Hear Res. 2007 Apr;226(1-2):168-77.


Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss.

Wang J, Ladrech S, Pujol R, Brabet P, Van De Water TR, Puel JL.

Cancer Res. 2004 Dec 15;64(24):9217-24.


JNK signaling in neomycin-induced vestibular hair cell death.

Sugahara K, Rubel EW, Cunningham LL.

Hear Res. 2006 Nov;221(1-2):128-35.


Synergistic ototoxicity due to noise exposure and aminoglycoside antibiotics.

Li H, Steyger PS.

Noise Health. 2009 Jan-Mar;11(42):26-32.


Cisplatin ototoxicity blocks sensory regeneration in the avian inner ear.

Slattery EL, Warchol ME.

J Neurosci. 2010 Mar 3;30(9):3473-81. doi: 10.1523/JNEUROSCI.4316-09.2010.


Cisplatin-induced hair cell death requires STAT1 and is attenuated by epigallocatechin gallate.

Schmitt NC, Rubel EW, Nathanson NM.

J Neurosci. 2009 Mar 25;29(12):3843-51. doi: 10.1523/JNEUROSCI.5842-08.2009.


Ototoxicity: therapeutic opportunities.

Rybak LP, Whitworth CA.

Drug Discov Today. 2005 Oct 1;10(19):1313-21. Review.


Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death.

Ylikoski J, Xing-Qun L, Virkkala J, Pirvola U.

Hear Res. 2002 Apr;166(1-2):33-43.


Piperine protects cisplatin-induced apoptosis via heme oxygenase-1 induction in auditory cells.

Choi BM, Kim SM, Park TK, Li G, Hong SJ, Park R, Chung HT, Kim BR.

J Nutr Biochem. 2007 Sep;18(9):615-22.


The injured cochlea as a target for inflammatory processes, initiation of cell death pathways and application of related otoprotectives strategies.

Abi-Hachem RN, Zine A, Van De Water TR.

Recent Pat CNS Drug Discov. 2010 Jun;5(2):147-63. Review.


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