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Items: 1 to 20 of 118

1.

Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity.

Rodriguez D, Ramesh C, Henson LH, Wilmeth L, Bryant BK, Kadavakollu S, Hirsch R, Montoya J, Howell PR, George JM, Alexander D, Johnson DL, Arterburn JB, Shuster CB.

Bioorg Med Chem. 2011 Sep 15;19(18):5446-53. doi: 10.1016/j.bmc.2011.07.054. Epub 2011 Jul 30.

2.

Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5.

Kaan HY, Weiss J, Menger D, Ulaganathan V, Tkocz K, Laggner C, Popowycz F, Joseph B, Kozielski F.

J Med Chem. 2011 Mar 24;54(6):1576-86. doi: 10.1021/jm100991m. Epub 2011 Feb 23.

PMID:
21344920
3.

Synthesis, biological evaluation and molecular docking studies of flavone and isoflavone derivatives as a novel class of KSP (kinesin spindle protein) inhibitors.

Dong JJ, Li QS, Liu ZP, Wang SF, Zhao MY, Yang YH, Wang XM, Zhu HL.

Eur J Med Chem. 2013;70:427-33. doi: 10.1016/j.ejmech.2013.09.042. Epub 2013 Oct 2.

PMID:
24184776
4.

De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors.

Jiang C, Yang L, Wu WT, Guo QL, You QD.

Bioorg Med Chem. 2011 Sep 15;19(18):5612-27. doi: 10.1016/j.bmc.2011.07.029. Epub 2011 Jul 22.

PMID:
21856161
5.

[Synthesis and antitumor activity of novel tetrahydro-beta-carboline derivatives as KSP inhibitors].

Ruan XQ, Chen M, Wu WT, You QD.

Yao Xue Xue Bao. 2013 Jul;48(7):1119-23. Chinese.

PMID:
24133978
6.

Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP.

Liu F, Yu LQ, Jiang C, Yang L, Wu WT, You QD.

Bioorg Med Chem. 2010 Jun 15;18(12):4167-77. doi: 10.1016/j.bmc.2010.05.024. Epub 2010 May 11.

PMID:
20537544
7.

Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity.

Wang F, Good JA, Rath O, Kaan HY, Sutcliffe OB, Mackay SP, Kozielski F.

J Med Chem. 2012 Feb 23;55(4):1511-25. doi: 10.1021/jm201195m. Epub 2012 Feb 13.

8.

Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.

Debonis S, Skoufias DA, Indorato RL, Liger F, Marquet B, Laggner C, Joseph B, Kozielski F.

J Med Chem. 2008 Mar 13;51(5):1115-25. doi: 10.1021/jm070606z. Epub 2008 Feb 12.

PMID:
18266314
9.

Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays.

Kiselyov AS, Semenova MN, Chernyshova NB, Leitao A, Samet AV, Kislyi KA, Raihstat MM, Oprea T, Lemcke H, Lantow M, Weiss DG, Ikizalp NN, Kuznetsov SA, Semenov VV.

Eur J Med Chem. 2010 May;45(5):1683-97. doi: 10.1016/j.ejmech.2009.12.072. Epub 2010 Jan 14.

PMID:
20110137
10.

Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors.

Nagarajan S, Skoufias DA, Kozielski F, Pae AN.

J Med Chem. 2012 Mar 22;55(6):2561-73. doi: 10.1021/jm201290v. Epub 2012 Mar 1.

PMID:
22309208
11.

Novel ATP-competitive kinesin spindle protein inhibitors.

Parrish CA, Adams ND, Auger KR, Burgess JL, Carson JD, Chaudhari AM, Copeland RA, Diamond MA, Donatelli CA, Duffy KJ, Faucette LF, Finer JT, Huffman WF, Hugger ED, Jackson JR, Knight SD, Luo L, Moore ML, Newlander KA, Ridgers LH, Sakowicz R, Shaw AN, Sung CM, Sutton D, Wood KW, Zhang SY, Zimmerman MN, Dhanak D.

J Med Chem. 2007 Oct 4;50(20):4939-52. Epub 2007 Aug 29.

PMID:
17725339
12.

Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines.

Demchuk DV, Samet AV, Chernysheva NB, Ushkarov VI, Stashina GA, Konyushkin LD, Raihstat MM, Firgang SI, Philchenkov AA, Zavelevich MP, Kuiava LM, Chekhun VF, Blokhin DY, Kiselyov AS, Semenova MN, Semenov VV.

Bioorg Med Chem. 2014 Jan 15;22(2):738-55. doi: 10.1016/j.bmc.2013.12.015. Epub 2013 Dec 12.

PMID:
24387982
13.

Structure-based design of new KSP-Eg5 inhibitors assisted by a targeted multicomponent reaction.

Carbajales C, Prado MÁ, Gutiérrez-de-Terán H, Cores A, Azuaje J, Novio S, Nuñez MJ, Fernández-García B, Sotelo E, García-Mera X, Sánchez-Lazo P, Freire-Garabal M, Coelho A.

Chembiochem. 2014 Jul 7;15(10):1471-80. doi: 10.1002/cbic.201402089. Epub 2014 Jun 18.

PMID:
24943831
14.

Antitumor activity of a kinesin inhibitor.

Sakowicz R, Finer JT, Beraud C, Crompton A, Lewis E, Fritsch A, Lee Y, Mak J, Moody R, Turincio R, Chabala JC, Gonzales P, Roth S, Weitman S, Wood KW.

Cancer Res. 2004 May 1;64(9):3276-80.

15.

Recent progress in the identification and clinical evaluation of inhibitors of the mitotic kinesin KSP.

Knight SD, Parrish CA.

Curr Top Med Chem. 2008;8(10):888-904. Review.

PMID:
18673173
16.

In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities.

DeBonis S, Skoufias DA, Lebeau L, Lopez R, Robin G, Margolis RL, Wade RH, Kozielski F.

Mol Cancer Ther. 2004 Sep;3(9):1079-90.

17.

Design, synthesis and evaluation of tetrahydroisoquinolines as new kinesin spindle protein inhibitors.

Jiang C, You Q, Liu F, Wu W, Guo Q, Chern J, Yang L, Chen M.

Chem Pharm Bull (Tokyo). 2009 Jun;57(6):567-71.

18.

Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP.

Coleman PJ, Schreier JD, Cox CD, Fraley ME, Garbaccio RM, Buser CA, Walsh ES, Hamilton K, Lobell RB, Rickert K, Tao W, Diehl RE, South VJ, Davide JP, Kohl NE, Yan Y, Kuo L, Prueksaritanont T, Li C, Mahan EA, Fernandez-Metzler C, Salata JJ, Hartman GD.

Bioorg Med Chem Lett. 2007 Oct 1;17(19):5390-5. Epub 2007 Aug 6.

PMID:
17761419
19.

Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes.

Watts CA, Richards FM, Bender A, Bond PJ, Korb O, Kern O, Riddick M, Owen P, Myers RM, Raff J, Gergely F, Jodrell DI, Ley SV.

Chem Biol. 2013 Nov 21;20(11):1399-410. doi: 10.1016/j.chembiol.2013.09.012. Epub 2013 Oct 24.

20.

Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.

Theoclitou ME, Aquila B, Block MH, Brassil PJ, Castriotta L, Code E, Collins MP, Davies AM, Deegan T, Ezhuthachan J, Filla S, Freed E, Hu H, Huszar D, Jayaraman M, Lawson D, Lewis PM, Nadella MV, Oza V, Padmanilayam M, Pontz T, Ronco L, Russell D, Whitston D, Zheng X.

J Med Chem. 2011 Oct 13;54(19):6734-50. doi: 10.1021/jm200629m. Epub 2011 Sep 7.

PMID:
21899292
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