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Items: 1 to 20 of 94

1.

Discovery of potent and novel S-nitrosoglutathione reductase inhibitors devoid of cytochrome P450 activities.

Sun X, Qiu J, Strong SA, Green LS, Wasley JW, Blonder JP, Colagiovanni DB, Mutka SC, Stout AM, Richards JP, Rosenthal GJ.

Bioorg Med Chem Lett. 2011 Oct 1;21(19):5849-53. doi: 10.1016/j.bmcl.2011.07.103. Epub 2011 Aug 3.

PMID:
21855338
2.

Structure-activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: carboxamide modification.

Sun X, Qiu J, Strong SA, Green LS, Wasley JW, Blonder JP, Colagiovanni DB, Stout AM, Mutka SC, Richards JP, Rosenthal GJ.

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2338-42. doi: 10.1016/j.bmcl.2012.01.047. Epub 2012 Feb 2.

PMID:
22342142
3.

Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement.

Sun X, Qiu J, Strong SA, Green LS, Wasley JW, Colagiovanni DB, Mutka SC, Blonder JP, Stout AM, Richards JP, Chun L, Rosenthal GJ.

Bioorg Med Chem Lett. 2011 Jun 15;21(12):3671-5. doi: 10.1016/j.bmcl.2011.04.086. Epub 2011 Apr 24.

PMID:
21570838
4.

A nonclinical safety and pharmacokinetic evaluation of N6022: a first-in-class S-nitrosoglutathione reductase inhibitor for the treatment of asthma.

Colagiovanni DB, Drolet DW, Langlois-Forget E, Piché MP, Looker D, Rosenthal GJ.

Regul Toxicol Pharmacol. 2012 Feb;62(1):115-24. doi: 10.1016/j.yrtph.2011.12.012. Epub 2011 Dec 24.

PMID:
22210450
5.

Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase.

Green LS, Chun LE, Patton AK, Sun X, Rosenthal GJ, Richards JP.

Biochemistry. 2012 Mar 13;51(10):2157-68. doi: 10.1021/bi201785u. Epub 2012 Feb 28.

PMID:
22335564
6.

Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation.

Blonder JP, Mutka SC, Sun X, Qiu J, Green LH, Mehra NK, Boyanapalli R, Suniga M, Look K, Delany C, Richards JP, Looker D, Scoggin C, Rosenthal GJ.

BMC Pulm Med. 2014 Jan 10;14:3. doi: 10.1186/1471-2466-14-3.

7.

Discovery of s-nitrosoglutathione reductase inhibitors: potential agents for the treatment of asthma and other inflammatory diseases.

Sun X, Wasley JW, Qiu J, Blonder JP, Stout AM, Green LS, Strong SA, Colagiovanni DB, Richards JP, Mutka SC, Chun L, Rosenthal GJ.

ACS Med Chem Lett. 2011 Mar 11;2(5):402-6. doi: 10.1021/ml200045s. eCollection 2011 May 12.

8.

Kinetic and cellular characterization of novel inhibitors of S-nitrosoglutathione reductase.

Sanghani PC, Davis WI, Fears SL, Green SL, Zhai L, Tang Y, Martin E, Bryan NS, Sanghani SP.

J Biol Chem. 2009 Sep 4;284(36):24354-62. doi: 10.1074/jbc.M109.019919. Epub 2009 Jul 11.

9.

The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy.

Barnett SD, Buxton ILO.

Crit Rev Biochem Mol Biol. 2017 Jun;52(3):340-354. doi: 10.1080/10409238.2017.1304353. Epub 2017 Apr 10. Review.

PMID:
28393572
10.

ADH IB expression, but not ADH III, is decreased in human lung cancer.

Mutka SC, Green LH, Verderber EL, Richards JP, Looker DL, Chlipala EA, Rosenthal GJ.

PLoS One. 2012;7(12):e52995. doi: 10.1371/journal.pone.0052995. Epub 2012 Dec 28.

11.

Discovering benzamide derivatives as glycogen phosphorylase inhibitors and their binding site at the enzyme.

Chen L, Li H, Liu J, Zhang L, Liu H, Jiang H.

Bioorg Med Chem. 2007 Nov 1;15(21):6763-74. Epub 2007 Aug 10.

PMID:
17719791
12.

Protection from experimental asthma by an endogenous bronchodilator.

Que LG, Liu L, Yan Y, Whitehead GS, Gavett SH, Schwartz DA, Stamler JS.

Science. 2005 Jun 10;308(5728):1618-21. Epub 2005 May 26.

13.

Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes.

Laufer SA, Wagner GK, Kotschenreuther DA, Albrecht W.

J Med Chem. 2003 Jul 17;46(15):3230-44.

PMID:
12852754
14.

S-nitrosoglutathione reductase: an important regulator in human asthma.

Que LG, Yang Z, Stamler JS, Lugogo NL, Kraft M.

Am J Respir Crit Care Med. 2009 Aug 1;180(3):226-31. doi: 10.1164/rccm.200901-0158OC. Epub 2009 Apr 24.

15.

Discovery of adamantyl ethanone derivatives as potent 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors.

Su X, Pradaux-Caggiano F, Thomas MP, Szeto MW, Halem HA, Culler MD, Vicker N, Potter BV.

ChemMedChem. 2010 Jul 5;5(7):1026-44. doi: 10.1002/cmdc.201000081.

PMID:
20486152
16.

O-Aminobenzoyl-S-nitrosoglutathione: A fluorogenic, cell permeable, pseudo-substrate for S-nitrosoglutathione reductase.

Sun BL, Palmer L, Alam SR, Adekoya I, Brown-Steinke K, Periasamy A, Mutus B.

Free Radic Biol Med. 2017 Jul;108:445-451. doi: 10.1016/j.freeradbiomed.2017.04.008. Epub 2017 Apr 15.

PMID:
28419866
17.

Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors.

Paquin I, Raeppel S, Leit S, Gaudette F, Zhou N, Moradei O, Saavedra O, Bernstein N, Raeppel F, Bouchain G, Fréchette S, Woo SH, Vaisburg A, Fournel M, Kalita A, Robert MF, Lu A, Trachy-Bourget MC, Yan PT, Liu J, Rahil J, MacLeod AR, Besterman JM, Li Z, Delorme D.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):1067-71. Epub 2007 Dec 10.

PMID:
18160287
18.

Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case of bioisosterism between a carboxylic acid moiety and that of a tetrazole.

Pegklidou K, Koukoulitsa C, Nicolaou I, Demopoulos VJ.

Bioorg Med Chem. 2010 Mar 15;18(6):2107-14. doi: 10.1016/j.bmc.2010.02.010. Epub 2010 Feb 11.

PMID:
20189816
19.

Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma.

Wu H, Romieu I, Sienra-Monge JJ, Estela Del Rio-Navarro B, Anderson DM, Jenchura CA, Li H, Ramirez-Aguilar M, Del Carmen Lara-Sanchez I, London SJ.

J Allergy Clin Immunol. 2007 Aug;120(2):322-8. Epub 2007 Jun 1.

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