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Ku must load directly onto the chromosome end in order to mediate its telomeric functions.

Lopez CR, Ribes-Zamora A, Indiviglio SM, Williams CL, Haricharan S, Bertuch AA.

PLoS Genet. 2011 Aug;7(8):e1002233. doi: 10.1371/journal.pgen.1002233. Epub 2011 Aug 11.


Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends.

Stellwagen AE, Haimberger ZW, Veatch JR, Gottschling DE.

Genes Dev. 2003 Oct 1;17(19):2384-95. Epub 2003 Sep 15.


Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model.

Pfingsten JS, Goodrich KJ, Taabazuing C, Ouenzar F, Chartrand P, Cech TR.

Cell. 2012 Mar 2;148(5):922-32. doi: 10.1016/j.cell.2012.01.033. Epub 2012 Feb 23.


The principal role of Ku in telomere length maintenance is promotion of Est1 association with telomeres.

Williams JM, Ouenzar F, Lemon LD, Chartrand P, Bertuch AA.

Genetics. 2014 Aug;197(4):1123-36. doi: 10.1534/genetics.114.164707. Epub 2014 May 30.


Ku Binding on Telomeres Occurs at Sites Distal from the Physical Chromosome Ends.

Larcher MV, Pasquier E, MacDonald RS, Wellinger RJ.

PLoS Genet. 2016 Dec 8;12(12):e1006479. doi: 10.1371/journal.pgen.1006479. eCollection 2016 Dec.


Distinct faces of the Ku heterodimer mediate DNA repair and telomeric functions.

Ribes-Zamora A, Mihalek I, Lichtarge O, Bertuch AA.

Nat Struct Mol Biol. 2007 Apr;14(4):301-7. Epub 2007 Mar 11.


The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.

Peterson SE, Stellwagen AE, Diede SJ, Singer MS, Haimberger ZW, Johnson CO, Tzoneva M, Gottschling DE.

Nat Genet. 2001 Jan;27(1):64-7.


Sequential loading of Saccharomyces cerevisiae Ku and Cdc13p to telomeres.

Wu TJ, Chiang YH, Lin YC, Tsai CR, Yu TY, Sung MT, Lee YH, Lin JJ.

J Biol Chem. 2009 May 8;284(19):12801-8. doi: 10.1074/jbc.M809131200. Epub 2009 Mar 9.


The DNA end-binding protein Ku regulates silencing at the internal HML and HMR loci in Saccharomyces cerevisiae.

Vandre CL, Kamakaka RT, Rivier DH.

Genetics. 2008 Nov;180(3):1407-18. doi: 10.1534/genetics.108.094490. Epub 2008 Sep 14.


Telomere maintenance is dependent on activities required for end repair of double-strand breaks.

Nugent CI, Bosco G, Ross LO, Evans SK, Salinger AP, Moore JK, Haber JE, Lundblad V.

Curr Biol. 1998 May 21;8(11):657-60.


TRF2 interaction with Ku heterotetramerization interface gives insight into c-NHEJ prevention at human telomeres.

Ribes-Zamora A, Indiviglio SM, Mihalek I, Williams CL, Bertuch AA.

Cell Rep. 2013 Oct 17;5(1):194-206. doi: 10.1016/j.celrep.2013.08.040. Epub 2013 Oct 3.


Yeast Ku as a regulator of chromosomal DNA end structure.

Gravel S, Larrivée M, Labrecque P, Wellinger RJ.

Science. 1998 May 1;280(5364):741-4.


Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP.

Zappulla DC, Goodrich KJ, Arthur JR, Gurski LA, Denham EM, Stellwagen AE, Cech TR.

RNA. 2011 Feb;17(2):298-311. doi: 10.1261/rna.2483611. Epub 2010 Dec 21.


Telomerase, Ku, and telomeric silencing in Saccharomyces cerevisiae.

Evans SK, Sistrunk ML, Nugent CI, Lundblad V.

Chromosoma. 1998 Dec;107(6-7):352-8.


Separation-of-function mutants of yeast Ku80 reveal a Yku80p-Sir4p interaction involved in telomeric silencing.

Roy R, Meier B, McAinsh AD, Feldmann HM, Jackson SP.

J Biol Chem. 2004 Jan 2;279(1):86-94. Epub 2003 Oct 9.


Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres.

Laroche T, Martin SG, Gotta M, Gorham HC, Pryde FE, Louis EJ, Gasser SM.

Curr Biol. 1998 May 21;8(11):653-6.

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