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Items: 1 to 20 of 295

1.

Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.

Arroyo JP, Lagnaz D, Ronzaud C, Vázquez N, Ko BS, Moddes L, Ruffieux-Daidié D, Hausel P, Koesters R, Yang B, Stokes JB, Hoover RS, Gamba G, Staub O.

J Am Soc Nephrol. 2011 Sep;22(9):1707-19. doi: 10.1681/ASN.2011020132. Epub 2011 Aug 18.

2.

WNK3 abrogates the NEDD4-2-mediated inhibition of the renal Na+-Cl- cotransporter.

Lagnaz D, Arroyo JP, Chávez-Canales M, Vázquez N, Rizzo F, Spirlí A, Debonneville A, Staub O, Gamba G.

Am J Physiol Renal Physiol. 2014 Aug 1;307(3):F275-86. doi: 10.1152/ajprenal.00574.2013. Epub 2014 Jun 11.

PMID:
24920754
3.

Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by Nedd4-2 phosphorylation and increased Na+ transport in cortical collecting duct cells.

Flores SY, Loffing-Cueni D, Kamynina E, Daidié D, Gerbex C, Chabanel S, Dudler J, Loffing J, Staub O.

J Am Soc Nephrol. 2005 Aug;16(8):2279-87. Epub 2005 Jun 15.

4.

Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites.

Chandran S, Li H, Dong W, Krasinska K, Adams C, Alexandrova L, Chien A, Hallows KR, Bhalla V.

J Biol Chem. 2011 Oct 28;286(43):37830-40. doi: 10.1074/jbc.M111.293233. Epub 2011 Sep 7.

5.

Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC.

Al-Qusairi L, Basquin D, Roy A, Stifanelli M, Rajaram RD, Debonneville A, Nita I, Maillard M, Loffing J, Subramanya AR, Staub O.

Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F330-42. doi: 10.1152/ajprenal.00002.2016. Epub 2016 Mar 23.

6.

Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway.

Rozansky DJ, Cornwall T, Subramanya AR, Rogers S, Yang YF, David LL, Zhu X, Yang CL, Ellison DH.

J Clin Invest. 2009 Sep;119(9):2601-12. doi: 10.1172/JCI38323. Epub 2009 Aug 17.

7.

Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype.

Faresse N, Lagnaz D, Debonneville A, Ismailji A, Maillard M, Fejes-Toth G, Náray-Fejes-Tóth A, Staub O.

Am J Physiol Renal Physiol. 2012 Apr 15;302(8):F977-85. doi: 10.1152/ajprenal.00535.2011. Epub 2012 Feb 1.

PMID:
22301619
8.

Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3.

Bhalla V, Daidié D, Li H, Pao AC, LaGrange LP, Wang J, Vandewalle A, Stockand JD, Staub O, Pearce D.

Mol Endocrinol. 2005 Dec;19(12):3073-84. Epub 2005 Aug 11.

PMID:
16099816
9.
10.

A naturally occurring human Nedd4-2 variant displays impaired ENaC regulation in Xenopus laevis oocytes.

Fouladkou F, Alikhani-Koopaei R, Vogt B, Flores SY, Malbert-Colas L, Lecomte MC, Loffing J, Frey FJ, Frey BM, Staub O.

Am J Physiol Renal Physiol. 2004 Sep;287(3):F550-61. Epub 2004 May 12.

PMID:
15140763
11.

Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2.

Edinger RS, Lebowitz J, Li H, Alzamora R, Wang H, Johnson JP, Hallows KR.

J Biol Chem. 2009 Jan 2;284(1):150-7. doi: 10.1074/jbc.M807358200. Epub 2008 Nov 3.

12.

COMMD1 downregulates the epithelial sodium channel through Nedd4-2.

Ke Y, Butt AG, Swart M, Liu YF, McDonald FJ.

Am J Physiol Renal Physiol. 2010 Jun;298(6):F1445-56. doi: 10.1152/ajprenal.00257.2009. Epub 2010 Mar 17.

PMID:
20237237
13.

Regulation of epithelial Na+ channels by aldosterone: role of Sgk1.

Lee IH, Campbell CR, Cook DI, Dinudom A.

Clin Exp Pharmacol Physiol. 2008 Feb;35(2):235-41. doi: 10.1111/j.1440-1681.2007.04844.x. Review.

PMID:
18197893
14.

Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1.

Vallon V, Schroth J, Lang F, Kuhl D, Uchida S.

Am J Physiol Renal Physiol. 2009 Sep;297(3):F704-12. doi: 10.1152/ajprenal.00030.2009. Epub 2009 Jul 1.

15.

AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2.

Bhalla V, Oyster NM, Fitch AC, Wijngaarden MA, Neumann D, Schlattner U, Pearce D, Hallows KR.

J Biol Chem. 2006 Sep 8;281(36):26159-69. Epub 2006 Jul 14.

16.

Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression.

Debonneville C, Flores SY, Kamynina E, Plant PJ, Tauxe C, Thomas MA, Münster C, Chraïbi A, Pratt JH, Horisberger JD, Pearce D, Loffing J, Staub O.

EMBO J. 2001 Dec 17;20(24):7052-9.

17.

14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase.

Ichimura T, Yamamura H, Sasamoto K, Tominaga Y, Taoka M, Kakiuchi K, Shinkawa T, Takahashi N, Shimada S, Isobe T.

J Biol Chem. 2005 Apr 1;280(13):13187-94. Epub 2005 Jan 26.

18.

Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation.

Wiemuth D, Lott JS, Ly K, Ke Y, Teesdale-Spittle P, Snyder PM, McDonald FJ.

PLoS One. 2010 Aug 13;5(8):e12163. doi: 10.1371/journal.pone.0012163.

19.

Metabolic acidosis has dual effects on sodium handling by rat kidney.

Faroqui S, Sheriff S, Amlal H.

Am J Physiol Renal Physiol. 2006 Aug;291(2):F322-31. Epub 2006 Feb 21.

PMID:
16495212
20.

Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases.

Embark HM, Böhmer C, Palmada M, Rajamanickam J, Wyatt AW, Wallisch S, Capasso G, Waldegger P, Seyberth HW, Waldegger S, Lang F.

Kidney Int. 2004 Nov;66(5):1918-25.

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