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Items: 1 to 20 of 116

1.

Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response.

Fribley AM, Cruz PG, Miller JR, Callaghan MU, Cai P, Narula N, Neubig RR, Showalter HD, Larsen SD, Kirchhoff PD, Larsen MJ, Burr DA, Schultz PJ, Jacobs RR, Tamayo-Castillo G, Ron D, Sherman DH, Kaufman RJ.

J Biomol Screen. 2011 Sep;16(8):825-35. doi: 10.1177/1087057111414893. Epub 2011 Aug 15.

2.

Celastrol induces unfolded protein response-dependent cell death in head and neck cancer.

Fribley AM, Miller JR, Brownell AL, Garshott DM, Zeng Q, Reist TE, Narula N, Cai P, Xi Y, Callaghan MU, Kodali V, Kaufman RJ.

Exp Cell Res. 2015 Jan 15;330(2):412-22. doi: 10.1016/j.yexcr.2014.08.014. Epub 2014 Aug 17.

3.

Cantharidins induce ER stress and a terminal unfolded protein response in OSCC.

Xi Y, Garshott DM, Brownell AL, Yoo GH, Lin HS, Freeburg TL, Yoo NG, Kaufman RJ, Callaghan MU, Fribley AM.

J Dent Res. 2015 Feb;94(2):320-9. doi: 10.1177/0022034514559376. Epub 2014 Nov 25.

4.

Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response.

Babcock JT, Nguyen HB, He Y, Hendricks JW, Wek RC, Quilliam LA.

J Biol Chem. 2013 May 31;288(22):15687-98. doi: 10.1074/jbc.M112.431056. Epub 2013 Apr 23.

5.

Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells.

Nawrocki ST, Carew JS, Dunner K Jr, Boise LH, Chiao PJ, Huang P, Abbruzzese JL, McConkey DJ.

Cancer Res. 2005 Dec 15;65(24):11510-9.

6.

Perturbation of proteasome function by bortezomib leading to ER stress-induced apoptotic cell death in cholangiocarcinoma.

Vaeteewoottacharn K, Kariya R, Matsuda K, Taura M, Wongkham C, Wongkham S, Okada S.

J Cancer Res Clin Oncol. 2013 Sep;139(9):1551-62. doi: 10.1007/s00432-013-1473-6. Epub 2013 Jul 23.

PMID:
23877657
7.

Mucin production determines sensitivity to bortezomib and gemcitabine in pancreatic cancer cells.

Wissniowski TT, Meister S, Hahn EG, Kalden JR, Voll R, Ocker M.

Int J Oncol. 2012 May;40(5):1581-9. doi: 10.3892/ijo.2012.1337. Epub 2012 Jan 18.

PMID:
22266985
8.

Curcumin sensitizes acute promyelocytic leukemia cells to unfolded protein response-induced apoptosis by blocking the loss of misfolded N-CoR protein.

Ng AP, Chng WJ, Khan M.

Mol Cancer Res. 2011 Jul;9(7):878-88. doi: 10.1158/1541-7786.MCR-10-0545. Epub 2011 May 20.

9.

Selective, potent blockade of the IRE1 and ATF6 pathways by 4-phenylbutyric acid analogues.

Zhang H, Nakajima S, Kato H, Gu L, Yoshitomi T, Nagai K, Shinmori H, Kokubo S, Kitamura M.

Br J Pharmacol. 2013 Oct;170(4):822-34. doi: 10.1111/bph.12306.

10.

6-Shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stress.

Hu R, Zhou P, Peng YB, Xu X, Ma J, Liu Q, Zhang L, Wen XD, Qi LW, Gao N, Li P.

PLoS One. 2012;7(6):e39664. doi: 10.1371/journal.pone.0039664. Epub 2012 Jun 29.

11.

Implication of unfolded protein response in resveratrol-induced inhibition of K562 cell proliferation.

Liu BQ, Gao YY, Niu XF, Xie JS, Meng X, Guan Y, Wang HQ.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):778-82. doi: 10.1016/j.bbrc.2009.11.137. Epub 2009 Nov 26.

PMID:
19944671
12.

Characterization of bortezomib-adapted I-45 mesothelioma cells.

Zhang L, Littlejohn JE, Cui Y, Cao X, Peddaboina C, Smythe WR.

Mol Cancer. 2010 May 18;9:110. doi: 10.1186/1476-4598-9-110.

13.

Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1.

Zhang HM, Ye X, Su Y, Yuan J, Liu Z, Stein DA, Yang D.

J Virol. 2010 Sep;84(17):8446-59. doi: 10.1128/JVI.01416-09. Epub 2010 Jun 16.

14.

Role of CAAT/enhancer binding protein homologous protein in panobinostat-mediated potentiation of bortezomib-induced lethal endoplasmic reticulum stress in mantle cell lymphoma cells.

Rao R, Nalluri S, Fiskus W, Savoie A, Buckley KM, Ha K, Balusu R, Joshi A, Coothankandaswamy V, Tao J, Sotomayor E, Atadja P, Bhalla KN.

Clin Cancer Res. 2010 Oct 1;16(19):4742-54. doi: 10.1158/1078-0432.CCR-10-0529. Epub 2010 Jul 20.

15.

Selective small molecule activator of the apoptotic arm of the UPR.

Flaherty DP, Golden JE, Liu C, Hedrick M, Gosalia P, Li Y, Milewski M, Sugarman E, Suyama E, Nguyen K, Vasile S, Salaniwal S, Stonich D, Su Y, Mangravita-Novo A, Vicchiarelli M, Smith LH, Diwan J, Chung TDY, Pinkerton AB, Aubé J, Miller JR, Garshott DM, Callaghan MU, Fribley AM, Kaufman RJ.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Apr 1 [updated 2013 Feb 28].

16.

Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy.

Vandewynckel YP, Laukens D, Bogaerts E, Paridaens A, Van den Bussche A, Verhelst X, Van Steenkiste C, Descamps B, Vanhove C, Libbrecht L, De Rycke R, Lambrecht BN, Geerts A, Janssens S, Van Vlierberghe H.

Hepatol Int. 2014 Oct 1;9(1):93-104. doi: 10.1007/s12072-014-9582-0. eCollection 2015 Jan.

18.

PKCδ regulates death receptor 5 expression induced by PS-341 through ATF4-ATF3/CHOP axis in human lung cancer cells.

Xu L, Su L, Liu X.

Mol Cancer Ther. 2012 Oct;11(10):2174-82. doi: 10.1158/1535-7163.MCT-12-0602. Epub 2012 Jul 30.

19.

The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK.

Chan JY, Luzuriaga J, Maxwell EL, West PK, Bensellam M, Laybutt DR.

Mol Cell Endocrinol. 2015 Sep 15;413:189-201. doi: 10.1016/j.mce.2015.06.025. Epub 2015 Jun 30.

PMID:
26135354
20.

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma.

Mimura N, Fulciniti M, Gorgun G, Tai YT, Cirstea D, Santo L, Hu Y, Fabre C, Minami J, Ohguchi H, Kiziltepe T, Ikeda H, Kawano Y, French M, Blumenthal M, Tam V, Kertesz NL, Malyankar UM, Hokenson M, Pham T, Zeng Q, Patterson JB, Richardson PG, Munshi NC, Anderson KC.

Blood. 2012 Jun 14;119(24):5772-81. doi: 10.1182/blood-2011-07-366633. Epub 2012 Apr 26.

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