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Items: 1 to 20 of 112

1.

Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism.

Fath MA, Ahmad IM, Smith CJ, Spence J, Spitz DR.

Clin Cancer Res. 2011 Oct 1;17(19):6206-17. doi: 10.1158/1078-0432.CCR-11-0736. Epub 2011 Aug 15.

2.

Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress.

Scarbrough PM, Mapuskar KA, Mattson DM, Gius D, Watson WH, Spitz DR.

Free Radic Biol Med. 2012 Jan 15;52(2):436-43. doi: 10.1016/j.freeradbiomed.2011.10.493. Epub 2011 Nov 4.

3.

Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism.

Sobhakumari A, Love-Homan L, Fletcher EV, Martin SM, Parsons AD, Spitz DR, Knudson CM, Simons AL.

PLoS One. 2012;7(10):e48175. doi: 10.1371/journal.pone.0048175. Epub 2012 Oct 31.

4.

Paclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H2O2-mediated oxidative stress.

Hadzic T, Aykin-Burns N, Zhu Y, Coleman MC, Leick K, Jacobson GM, Spitz DR.

Free Radic Biol Med. 2010 Apr 15;48(8):1024-33. doi: 10.1016/j.freeradbiomed.2010.01.018. Epub 2010 Jan 18.

5.

Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer.

Li L, Fath MA, Scarbrough PM, Watson WH, Spitz DR.

Redox Biol. 2015;4:127-35. doi: 10.1016/j.redox.2014.12.001. Epub 2014 Dec 10.

6.
7.

Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells.

Fath MA, Diers AR, Aykin-Burns N, Simons AL, Hua L, Spitz DR.

Cancer Biol Ther. 2009 Jul;8(13):1228-36. Epub 2009 Jul 6.

8.

Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin- and Glutathione-Dependent Metabolism.

Rodman SN 3rd, Spence JM, Ronnfeldt TJ, Zhu Y, Solst SR, O'Neill RA, Allen BG, Guan X, Spitz DR, Fath MA.

Radiat Res. 2016 Sep 19. [Epub ahead of print]

PMID:
27643875
9.

2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism.

Lin X, Zhang F, Bradbury CM, Kaushal A, Li L, Spitz DR, Aft RL, Gius D.

Cancer Res. 2003 Jun 15;63(12):3413-7.

10.

Inhibition of glutathione and thioredoxin metabolism enhances sensitivity to perifosine in head and neck cancer cells.

Simons AL, Parsons AD, Foster KA, Orcutt KP, Fath MA, Spitz DR.

J Oncol. 2009;2009:519563. doi: 10.1155/2009/519563. Epub 2009 Sep 2.

11.

Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose.

Andringa KK, Coleman MC, Aykin-Burns N, Hitchler MJ, Walsh SA, Domann FE, Spitz DR.

Cancer Res. 2006 Feb 1;66(3):1605-10.

12.

Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems.

Go YM, Roede JR, Walker DI, Duong DM, Seyfried NT, Orr M, Liang Y, Pennell KD, Jones DP.

Mol Cell Proteomics. 2013 Nov;12(11):3285-96. doi: 10.1074/mcp.M113.030437. Epub 2013 Aug 14.

13.

Enhanced response of human head and neck cancer xenograft tumors to cisplatin combined with 2-deoxy-D-glucose correlates with increased 18F-FDG uptake as determined by PET imaging.

Simons AL, Fath MA, Mattson DM, Smith BJ, Walsh SA, Graham MM, Hichwa RD, Buatti JM, Dornfeld K, Spitz DR.

Int J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1222-30.

14.

Dual targeting of the thioredoxin and glutathione antioxidant systems in malignant B cells: a novel synergistic therapeutic approach.

Kiebala M, Skalska J, Casulo C, Brookes PS, Peterson DR, Hilchey SP, Dai Y, Grant S, Maggirwar SB, Bernstein SH.

Exp Hematol. 2015 Feb;43(2):89-99. doi: 10.1016/j.exphem.2014.10.004. Epub 2014 Oct 22.

15.

2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress.

Ahmad IM, Abdalla MY, Aykin-Burns N, Simons AL, Oberley LW, Domann FE, Spitz DR.

Free Radic Biol Med. 2008 Mar 1;44(5):826-34. Epub 2007 Nov 28.

16.

2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer.

Coleman MC, Asbury CR, Daniels D, Du J, Aykin-Burns N, Smith BJ, Li L, Spitz DR, Cullen JJ.

Free Radic Biol Med. 2008 Feb 1;44(3):322-31. doi: 10.1016/j.freeradbiomed.2007.08.032. Epub 2007 Oct 16.

PMID:
18215740
17.

Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts.

Allen BG, Bhatia SK, Buatti JM, Brandt KE, Lindholm KE, Button AM, Szweda LI, Smith BJ, Spitz DR, Fath MA.

Clin Cancer Res. 2013 Jul 15;19(14):3905-13. doi: 10.1158/1078-0432.CCR-12-0287. Epub 2013 Jun 6.

18.

Intracellular glutathione content influences the sensitivity of lung cancer cell lines to methylseleninic acid.

Liu C, Liu H, Li Y, Wu Z, Zhu Y, Wang T, Gao AC, Chen J, Zhou Q.

Mol Carcinog. 2012 Apr;51(4):303-14. doi: 10.1002/mc.20781. Epub 2011 Apr 22.

PMID:
21520298
19.

2-deoxy-D-Glucose Synergizes with Doxorubicin or L-Buthionine Sulfoximine to Reduce Adhesion and Migration of Breast Cancer Cells.

Mustafa EH, Mahmoud HT, Al-Hudhud MY, Abdalla MY, Ahmad IM, Yasin SR, Elkarmi AZ, Tahtamouni LH.

Asian Pac J Cancer Prev. 2015;16(8):3213-22.

20.

Chemosensitization of L-phenylalanine mustard by the thiol-modulating agent buthionine sulfoximine.

Kramer RA, Greene K, Ahmad S, Vistica DT.

Cancer Res. 1987 Mar 15;47(6):1593-7.

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