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Items: 1 to 20 of 134

1.

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation.

Chen X, Niu H, Chung WH, Zhu Z, Papusha A, Shim EY, Lee SE, Sung P, Ira G.

Nat Struct Mol Biol. 2011 Aug 14;18(9):1015-9. doi: 10.1038/nsmb.2105.

2.

Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks.

Shim EY, Chung WH, Nicolette ML, Zhang Y, Davis M, Zhu Z, Paull TT, Ira G, Lee SE.

EMBO J. 2010 Oct 6;29(19):3370-80. doi: 10.1038/emboj.2010.219. Epub 2010 Sep 10.

3.

DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2.

Cejka P, Cannavo E, Polaczek P, Masuda-Sasa T, Pokharel S, Campbell JL, Kowalczykowski SC.

Nature. 2010 Sep 2;467(7311):112-6. doi: 10.1038/nature09355.

4.

Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends.

Zhu Z, Chung WH, Shim EY, Lee SE, Ira G.

Cell. 2008 Sep 19;134(6):981-94. doi: 10.1016/j.cell.2008.08.037.

5.

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.

Costelloe T, Louge R, Tomimatsu N, Mukherjee B, Martini E, Khadaroo B, Dubois K, Wiegant WW, Thierry A, Burma S, van Attikum H, Llorente B.

Nature. 2012 Sep 27;489(7417):581-4. doi: 10.1038/nature11353. Epub 2012 Sep 9.

6.

Processing of meiotic DNA double strand breaks requires cyclin-dependent kinase and multiple nucleases.

Manfrini N, Guerini I, Citterio A, Lucchini G, Longhese MP.

J Biol Chem. 2010 Apr 9;285(15):11628-37. doi: 10.1074/jbc.M110.104083. Epub 2010 Feb 11.

7.

Relationship of DNA degradation by Saccharomyces cerevisiae exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection.

Cannavo E, Cejka P, Kowalczykowski SC.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):E1661-8. doi: 10.1073/pnas.1305166110. Epub 2013 Apr 15.

8.

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.

Niu H, Chung WH, Zhu Z, Kwon Y, Zhao W, Chi P, Prakash R, Seong C, Liu D, Lu L, Ira G, Sung P.

Nature. 2010 Sep 2;467(7311):108-11. doi: 10.1038/nature09318.

9.

Sae2 Function at DNA Double-Strand Breaks Is Bypassed by Dampening Tel1 or Rad53 Activity.

Gobbini E, Villa M, Gnugnoli M, Menin L, Clerici M, Longhese MP.

PLoS Genet. 2015 Nov 19;11(11):e1005685. doi: 10.1371/journal.pgen.1005685. eCollection 2015 Nov.

10.

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing.

Mimitou EP, Symington LS.

Nature. 2008 Oct 9;455(7214):770-4. doi: 10.1038/nature07312. Epub 2008 Sep 21.

11.

Mre11-Rad50-Xrs2 and Sae2 promote 5' strand resection of DNA double-strand breaks.

Nicolette ML, Lee K, Guo Z, Rani M, Chow JM, Lee SE, Paull TT.

Nat Struct Mol Biol. 2010 Dec;17(12):1478-85. doi: 10.1038/nsmb.1957. Epub 2010 Nov 21.

12.

The 9-1-1 checkpoint clamp stimulates DNA resection by Dna2-Sgs1 and Exo1.

Ngo GH, Balakrishnan L, Dubarry M, Campbell JL, Lydall D.

Nucleic Acids Res. 2014;42(16):10516-28. doi: 10.1093/nar/gku746. Epub 2014 Aug 13.

13.

Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.

Nakada D, Hirano Y, Sugimoto K.

Mol Cell Biol. 2004 Nov;24(22):10016-25.

14.

DNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous Recombination.

Cejka P.

J Biol Chem. 2015 Sep 18;290(38):22931-8. doi: 10.1074/jbc.R115.675942. Epub 2015 Jul 31. Review.

15.

Dna2 is involved in CA strand resection and nascent lagging strand completion at native yeast telomeres.

Budd ME, Campbell JL.

J Biol Chem. 2013 Oct 11;288(41):29414-29. doi: 10.1074/jbc.M113.472456. Epub 2013 Aug 20.

16.

The non-homologous end-joining factor Nej1 inhibits resection mediated by Dna2-Sgs1 nuclease-helicase at DNA double strand breaks.

Sorenson KS, Mahaney BL, Lees-Miller SP, Cobb JA.

J Biol Chem. 2017 Sep 1;292(35):14576-14586. doi: 10.1074/jbc.M117.796011. Epub 2017 Jul 5.

PMID:
28679532
17.

Caffeine impairs resection during DNA break repair by reducing the levels of nucleases Sae2 and Dna2.

Tsabar M, Eapen VV, Mason JM, Memisoglu G, Waterman DP, Long MJ, Bishop DK, Haber JE.

Nucleic Acids Res. 2015 Aug 18;43(14):6889-901. doi: 10.1093/nar/gkv520. Epub 2015 May 27.

18.

Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.

Ferrari M, Dibitetto D, De Gregorio G, Eapen VV, Rawal CC, Lazzaro F, Tsabar M, Marini F, Haber JE, Pellicioli A.

PLoS Genet. 2015 Jan 8;11(1):e1004928. doi: 10.1371/journal.pgen.1004928. eCollection 2015 Jan.

19.

Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines.

Hoa NN, Akagawa R, Yamasaki T, Hirota K, Sasa K, Natsume T, Kobayashi J, Sakuma T, Yamamoto T, Komatsu K, Kanemaki MT, Pommier Y, Takeda S, Sasanuma H.

Genes Cells. 2015 Dec;20(12):1059-76. doi: 10.1111/gtc.12310. Epub 2015 Nov 2.

20.

DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells.

Sturzenegger A, Burdova K, Kanagaraj R, Levikova M, Pinto C, Cejka P, Janscak P.

J Biol Chem. 2014 Sep 26;289(39):27314-26. doi: 10.1074/jbc.M114.578823. Epub 2014 Aug 13.

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