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Hyperglycemia-induced O-GlcNAcylation and truncation of 4E-BP1 protein in liver of a mouse model of type 1 diabetes.

Dennis MD, Schrufer TL, Bronson SK, Kimball SR, Jefferson LS.

J Biol Chem. 2011 Sep 30;286(39):34286-97. doi: 10.1074/jbc.M111.259457. Epub 2011 Aug 12.


Hyperglycemia mediates a shift from cap-dependent to cap-independent translation via a 4E-BP1-dependent mechanism.

Dennis MD, Shenberger JS, Stanley BA, Kimball SR, Jefferson LS.

Diabetes. 2013 Jul;62(7):2204-14. doi: 10.2337/db12-1453. Epub 2013 Feb 22.


The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction.

Miller WP, Mihailescu ML, Yang C, Barber AJ, Kimball SR, Jefferson LS, Dennis MD.

Invest Ophthalmol Vis Sci. 2016 Mar;57(3):1327-37. doi: 10.1167/iovs.15-18719.


Regulated in development and DNA damage 1 is necessary for hyperglycemia-induced vascular endothelial growth factor expression in the retina of diabetic rodents.

Dennis MD, Kimball SR, Fort PE, Jefferson LS.

J Biol Chem. 2015 Feb 6;290(6):3865-74. doi: 10.1074/jbc.M114.623058. Epub 2014 Dec 29.


Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture.

Schrufer TL, Antonetti DA, Sonenberg N, Kimball SR, Gardner TW, Jefferson LS.

Diabetes. 2010 Sep;59(9):2107-16. doi: 10.2337/db10-0148. Epub 2010 Jun 14.


Activation of p53 stimulates proteasome-dependent truncation of eIF4E-binding protein 1 (4E-BP1).

Constantinou C, Elia A, Clemens MJ.

Biol Cell. 2008 May;100(5):279-89.


New hierarchical phosphorylation pathway of the translational repressor eIF4E-binding protein 1 (4E-BP1) in ischemia-reperfusion stress.

Ayuso MI, Hernández-Jiménez M, Martín ME, Salinas M, Alcázar A.

J Biol Chem. 2010 Nov 5;285(45):34355-63. doi: 10.1074/jbc.M110.135103. Epub 2010 Aug 24.


Seasonal and state-dependent changes of eIF4E and 4E-BP1 during mammalian hibernation: implications for the control of translation during torpor.

van Breukelen F, Sonenberg N, Martin SL.

Am J Physiol Regul Integr Comp Physiol. 2004 Aug;287(2):R349-53. Epub 2004 Apr 1.


Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins.

Niedzwiecka A, Marcotrigiano J, Stepinski J, Jankowska-Anyszka M, Wyslouch-Cieszynska A, Dadlez M, Gingras AC, Mak P, Darzynkiewicz E, Sonenberg N, Burley SK, Stolarski R.

J Mol Biol. 2002 Jun 7;319(3):615-35.


Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation.

Anthony JC, Reiter AK, Anthony TG, Crozier SJ, Lang CH, MacLean DA, Kimball SR, Jefferson LS.

Diabetes. 2002 Apr;51(4):928-36.


L-serine deficiency caused by genetic Phgdh deletion leads to robust induction of 4E-BP1 and subsequent repression of translation initiation in the developing central nervous system.

Sayano T, Kawakami Y, Kusada W, Suzuki T, Kawano Y, Watanabe A, Takashima K, Arimoto Y, Esaki K, Wada A, Yoshizawa F, Watanabe M, Okamoto M, Hirabayashi Y, Furuya S.

FEBS J. 2013 Mar;280(6):1502-17. doi: 10.1111/febs.12146. Epub 2013 Feb 24.


Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1.

Tee AR, Tee JA, Blenis J.

FEBS Lett. 2004 Apr 23;564(1-2):58-62.


Inhibition of mammalian target of rapamycin (mTOR) signalling in C2C12 myoblasts prevents myogenic differentiation without affecting the hyperphosphorylation of 4E-BP1.

Willett M, Cowan JL, Vlasak M, Coldwell MJ, Morley SJ.

Cell Signal. 2009 Oct;21(10):1504-12. doi: 10.1016/j.cellsig.2009.05.009. Epub 2009 May 27.


Oral administration of leucine stimulates phosphorylation of 4E-bP1 and S6K 1 in skeletal muscle but not in liver of diabetic rats.

Yoshizawa F, Hirayama S, Sekizawa H, Nagasawa T, Sugahara K.

J Nutr Sci Vitaminol (Tokyo). 2002 Feb;48(1):59-64.


Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis.

Dumstorf CA, Konicek BW, McNulty AM, Parsons SH, Furic L, Sonenberg N, Graff JR.

Mol Cancer Ther. 2010 Dec;9(12):3158-63. doi: 10.1158/1535-7163.MCT-10-0413. Epub 2010 Oct 22.


Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity.

Tsai S, Sitzmann JM, Dastidar SG, Rodriguez AA, Vu SL, McDonald CE, Academia EC, O'Leary MN, Ashe TD, La Spada AR, Kennedy BK.

J Clin Invest. 2015 Aug 3;125(8):2952-64. doi: 10.1172/JCI77361. Epub 2015 Jun 29.


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