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The biofilm inhibitor carolacton disturbs membrane integrity and cell division of Streptococcus mutans through the serine/threonine protein kinase PknB.

Reck M, Rutz K, Kunze B, Tomasch J, Surapaneni SK, Schulz S, Wagner-Döbler I.

J Bacteriol. 2011 Oct;193(20):5692-706. doi: 10.1128/JB.05424-11. Epub 2011 Aug 12.


Damage of Streptococcus mutans biofilms by carolacton, a secondary metabolite from the myxobacterium Sorangium cellulosum.

Kunze B, Reck M, Dötsch A, Lemme A, Schummer D, Irschik H, Steinmetz H, Wagner-Döbler I.

BMC Microbiol. 2010 Jul 26;10:199. doi: 10.1186/1471-2180-10-199.


Two-dimensional gel-based proteomic of the caries causative bacterium Streptococcus mutans UA159 and insight into the inhibitory effect of carolacton.

Li J, Wang W, Wang Y, Zeng AP.

Proteomics. 2013 Dec;13(23-24):3470-7. doi: 10.1002/pmic.201300077. Epub 2013 Nov 20.


Construction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton.

Sudhakar P, Reck M, Wang W, He FQ, Wagner-Döbler I, Zeng AP.

BMC Genomics. 2014 May 12;15:362. doi: 10.1186/1471-2164-15-362. Erratum in: BMC Genomics. 2014;15:739. Dobler, Irene W [corrected to Wagner-Döbler, Irene].


The Streptococcus mutans serine/threonine kinase, PknB, regulates competence development, bacteriocin production, and cell wall metabolism.

Banu LD, Conrads G, Rehrauer H, Hussain H, Allan E, van der Ploeg JR.

Infect Immun. 2010 May;78(5):2209-20. doi: 10.1128/IAI.01167-09. Epub 2010 Mar 15.


Synthesis of new carolacton derivatives and their activity against biofilms of oral bacteria.

Stumpp N, Premnath P, Schmidt T, Ammermann J, Dräger G, Reck M, Jansen R, Stiesch M, Wagner-Döbler I, Kirschning A.

Org Biomol Chem. 2015 May 28;13(20):5765-74. doi: 10.1039/c5ob00460h. Epub 2015 Apr 22.


Dental composite materials containing carolacton inhibit biofilm growth of Streptococcus mutans.

Apel C, Barg A, Rheinberg A, Conrads G, Wagner-Döbler I.

Dent Mater. 2013 Nov;29(11):1188-99. doi: 10.1016/ Epub 2013 Oct 4.


The biofilm inhibitor Carolacton inhibits planktonic growth of virulent pneumococci via a conserved target.

Donner J, Reck M, Bergmann S, Kirschning A, Müller R, Wagner-Döbler I.

Sci Rep. 2016 Jul 11;6:29677. doi: 10.1038/srep29677.


Carolacton Treatment Causes Delocalization of the Cell Division Proteins PknB and DivIVa in Streptococcus mutans in vivo.

Reck M, Wagner-Döbler I.

Front Microbiol. 2016 May 11;7:684. doi: 10.3389/fmicb.2016.00684. eCollection 2016.


Novel two-component regulatory system involved in biofilm formation and acid resistance in Streptococcus mutans.

Li YH, Lau PC, Tang N, Svensäter G, Ellen RP, Cvitkovitch DG.

J Bacteriol. 2002 Nov;184(22):6333-42.


[Carolacton--a highly potent inhibitor of biofilms].

Schmitz J.

Pharm Unserer Zeit. 2012 Jul;41(4):271. doi: 10.1002/pauz.201290067. German. No abstract available.


SMU.746-SMU.747, a putative membrane permease complex, is involved in aciduricity, acidogenesis, and biofilm formation in Streptococcus mutans.

Król JE, Biswas S, King C, Biswas I.

J Bacteriol. 2014 Jan;196(1):129-39. doi: 10.1128/JB.00960-13. Epub 2013 Oct 18.


Total synthesis of carolacton, a highly potent biofilm inhibitor.

Schmidt T, Kirschning A.

Angew Chem Int Ed Engl. 2012 Jan 23;51(4):1063-6. doi: 10.1002/anie.201106762. Epub 2011 Dec 9. No abstract available.


A quorum-sensing signaling system essential for genetic competence in Streptococcus mutans is involved in biofilm formation.

Li YH, Tang N, Aspiras MB, Lau PC, Lee JH, Ellen RP, Cvitkovitch DG.

J Bacteriol. 2002 May;184(10):2699-708.


Cell density modulates acid adaptation in Streptococcus mutans: implications for survival in biofilms.

Li YH, Hanna MN, Svensäter G, Ellen RP, Cvitkovitch DG.

J Bacteriol. 2001 Dec;183(23):6875-84.


Targets for hydrogen-peroxide-induced damage to suspension and biofilm cells of Streptococcus mutans.

Baldeck JD, Marquis RE.

Can J Microbiol. 2008 Oct;54(10):868-75. doi: 10.1139/w08-078.


Functional genomics approach to identifying genes required for biofilm development by Streptococcus mutans.

Wen ZT, Burne RA.

Appl Environ Microbiol. 2002 Mar;68(3):1196-203. Erratum in: Appl Environ Microbiol. 2003 Jan;69(1):722..


Deficiency of BrpB causes major defects in cell division, stress responses and biofilm formation by Streptococcus mutans.

Bitoun JP, Liao S, Xie GG, Beatty WL, Wen ZT.

Microbiology. 2014 Jan;160(Pt 1):67-78. doi: 10.1099/mic.0.072884-0. Epub 2013 Nov 4.

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