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Elucidation of the molecular basis of selective recognition uncovers the interaction site for the core domain of scorpion alpha-toxins on sodium channels.

Gur M, Kahn R, Karbat I, Regev N, Wang J, Catterall WA, Gordon D, Gurevitz M.

J Biol Chem. 2011 Oct 7;286(40):35209-17. doi: 10.1074/jbc.M111.259507. Epub 2011 Aug 8.


Mapping of scorpion toxin receptor sites at voltage-gated sodium channels.

Gurevitz M.

Toxicon. 2012 Sep 15;60(4):502-11. doi: 10.1016/j.toxicon.2012.03.022. Epub 2012 Apr 4.


Positions under positive selection--key for selectivity and potency of scorpion alpha-toxins.

Weinberger H, Moran Y, Gordon D, Turkov M, Kahn R, Gurevitz M.

Mol Biol Evol. 2010 May;27(5):1025-34. doi: 10.1093/molbev/msp310. Epub 2009 Dec 17.


NMR analysis of interaction of LqhalphaIT scorpion toxin with a peptide corresponding to the D4/S3-S4 loop of insect para voltage-gated sodium channel.

Schnur E, Turkov M, Kahn R, Gordon D, Gurevitz M, Anglister J.

Biochemistry. 2008 Jan 22;47(3):911-21. Epub 2007 Dec 23.


Molecular requirements for recognition of brain voltage-gated sodium channels by scorpion alpha-toxins.

Kahn R, Karbat I, Ilan N, Cohen L, Sokolov S, Catterall WA, Gordon D, Gurevitz M.

J Biol Chem. 2009 Jul 31;284(31):20684-91. doi: 10.1074/jbc.M109.021303. Epub 2009 Jun 9.


The specificity of Av3 sea anemone toxin for arthropods is determined at linker DI/SS2-S6 in the pore module of target sodium channels.

Gur Barzilai M, Kahn R, Regev N, Gordon D, Moran Y, Gurevitz M.

Biochem J. 2014 Oct 15;463(2):271-7. doi: 10.1042/BJ20140576.


Design of a specific activator for skeletal muscle sodium channels uncovers channel architecture.

Cohen L, Ilan N, Gur M, Stühmer W, Gordon D, Gurevitz M.

J Biol Chem. 2007 Oct 5;282(40):29424-30. Epub 2007 Aug 8.


Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels.

Zhang JZ, Yarov-Yarovoy V, Scheuer T, Karbat I, Cohen L, Gordon D, Gurevitz M, Catterall WA.

J Biol Chem. 2011 Sep 23;286(38):33641-51. doi: 10.1074/jbc.M111.282509. Epub 2011 Jul 27.


Binding modes and functional surface of anti-mammalian scorpion α-toxins to sodium channels.

Chen R, Chung SH.

Biochemistry. 2012 Oct 2;51(39):7775-82. doi: 10.1021/bi300776g. Epub 2012 Sep 21.


Scorpion toxins affecting sodium current inactivation bind to distinct homologous receptor sites on rat brain and insect sodium channels.

Gordon D, Martin-Eauclaire MF, Cestèle S, Kopeyan C, Carlier E, Khalifa RB, Pelhate M, Rochat H.

J Biol Chem. 1996 Apr 5;271(14):8034-45.


Mammalian skeletal muscle voltage-gated sodium channels are affected by scorpion depressant "insect-selective" toxins when preconditioned.

Cohen L, Troub Y, Turkov M, Gilles N, Ilan N, Benveniste M, Gordon D, Gurevitz M.

Mol Pharmacol. 2007 Nov;72(5):1220-7. Epub 2007 Aug 24.


The differential preference of scorpion alpha-toxins for insect or mammalian sodium channels: implications for improved insect control.

Gordon D, Karbat I, Ilan N, Cohen L, Kahn R, Gilles N, Dong K, Stühmer W, Tytgat J, Gurevitz M.

Toxicon. 2007 Mar 15;49(4):452-72. Epub 2006 Nov 28. Review.


Investigation of the relationship between the structure and function of Ts2, a neurotoxin from Tityus serrulatus venom.

Cologna CT, Peigneur S, Rustiguel JK, Nonato MC, Tytgat J, Arantes EC.

FEBS J. 2012 Apr;279(8):1495-504. doi: 10.1111/j.1742-4658.2012.08545.x.


Mapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated Na(+) channels.

Zhang JZ, Yarov-Yarovoy V, Scheuer T, Karbat I, Cohen L, Gordon D, Gurevitz M, Catterall WA.

J Biol Chem. 2012 Aug 31;287(36):30719-28. doi: 10.1074/jbc.M112.370742. Epub 2012 Jul 2.


Isolation and characterization of two novel scorpion toxins: The alpha-toxin-like CeII8, specific for Na(v)1.7 channels and the classical anti-mammalian CeII9, specific for Na(v)1.4 channels.

Vandendriessche T, Olamendi-Portugal T, Zamudio FZ, Possani LD, Tytgat J.

Toxicon. 2010 Sep 15;56(4):613-23. doi: 10.1016/j.toxicon.2010.06.008. Epub 2010 Jun 19.


Evolutionary diversification of Mesobuthus α-scorpion toxins affecting sodium channels.

Zhu S, Peigneur S, Gao B, Lu X, Cao C, Tytgat J.

Mol Cell Proteomics. 2012 Jan;11(1):M111.012054. doi: 10.1074/mcp.M111.012054. Epub 2011 Oct 3.


Common features in the functional surface of scorpion beta-toxins and elements that confer specificity for insect and mammalian voltage-gated sodium channels.

Cohen L, Karbat I, Gilles N, Ilan N, Benveniste M, Gordon D, Gurevitz M.

J Biol Chem. 2005 Feb 11;280(6):5045-53. Epub 2004 Nov 29.


Mapping the receptor site for alpha-scorpion toxins on a Na+ channel voltage sensor.

Wang J, Yarov-Yarovoy V, Kahn R, Gordon D, Gurevitz M, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15426-31. doi: 10.1073/pnas.1112320108. Epub 2011 Aug 29. Erratum in: Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3645.

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